Výsledky vyhledávání - "Patricia A Culp"

Akademický článek

Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenografts.

Autor: Ludmilla de Plater, Anne Vincent-Salomon, Frédérique Berger, André Nicolas, Sophie Vacher, Eléonore Gravier, Aurélie Thuleau, Narjesse Karboul, Marion Richardson, Clément Elbaz, Elisabetta Marangoni, Ivan Bièche, Xavier Paoletti, Sergio Roman-Roman, Patricia A Culp, Bernard Asselain, Véronique Diéras, Didier Decaudin

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e104227 (2014)

Purpose(1) To determine TweakR expression in human breast cancers (BC), (2) evaluate the antitumor effect of the anti-TweakR antibody PDL192, used alone or after chemotherapy-induced complete remission (CR), on patient-derived BC xenografts (PDX) and

Externí odkaz: https://doaj.org/article/8c0c43e5b4134d31b4cbe09a27a2de7f

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Data from Antibodies to TWEAK Receptor Inhibit Human Tumor Growth through Dual Mechanisms

Autor: Robert Dubridge, Vanitha Ramakrishnan, David B. Powers, Debra T. Chao, Eric D. Hsi, Marjorie James, Marie Cardenas, Jennifer Grove, Ferdinand Evangelista, Melanie H.L. Wong, Roxanne Steinle, Mien Sho, Mian Su, Suzanne E. Ybarra, Pui Seto, Johnny Yin, Yongke Zhang, Donghee Choi, Patricia A. Culp

Purpose: Targeted therapeutics have significantly changed the outcome for patients diagnosed with cancer. Still, effective therapeutic intervention does not exist for many cancers and much remains to be done. The objective of this study was to identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c90a289cf91f77e4c3cc630c736c91
https://doi.org/10.1158/1078-0432.c.6517582

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Akademický článek

Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells

Autor: Shiming Ye, Melvin I. Fox, Nicole A. Belmar, Mien Sho, Debra T. Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F. Keller, Gary C. Starling, Patricia A. Culp

Publikováno v: Journal of Immunology Research, Vol 2017 (2017)

Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved i

Externí odkaz: https://doaj.org/article/14443094aa82421d8333bf5917c19588

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CRISPR/Cas9 disruption of EpCAM Exon 2 results in cell-surface expression of a truncated protein targeted by an EpCAM specific T cell engager

Autor: Andisheh Bagheri, Patricia A. Culp, Robert B. DuBridge, Tseng-hui Timothy Chen

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101205-(2022)

CRISPR/Cas9 gene-editing technology allows researchers to study protein function by specifically introducing double-stranded breaks in the gene of interest then analyze its subsequent loss in sensitive biological assays. To help characterize one of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa9d70916ebbec68159bf63bda4ce4
http://europepmc.org/articles/PMC8761601

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Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenografts

Autor: Marion Richardson, Didier Decaudin, Sergio Roman-Roman, Aurélie Thuleau, Ivan Bièche, Véronique Diéras, Patricia A. Culp, C. Elbaz, Narjesse Karboul, Anne Vincent-Salomon, Sophie Vacher, Bernard Asselain, André Nicolas, Eléonore Gravier, Elisabetta Marangoni, Frédérique Berger, Ludmilla de Plater, Xavier Paoletti

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e104227 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaf31249c8e2844f7e83616e4948061
https://doaj.org/article/8c0c43e5b4134d31b4cbe09a27a2de7f

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Nuclear Factor κB is required for tumor growth inhibition mediated by enavatuzumab (PDL192), a humanized monoclonal antibody to TweakR

Autor: James W. Purcell, Han K. Kim, Sonia G. Tanlimco, Minhtam eDoan, Melvin eFox, Peter eLambert, Debra T. Chao, Mien eSho, Keith E. Wilson, Gary C. Starling, Patricia A. Culp

Publikováno v: Frontiers in Immunology, Vol 4 (2014)
Frontiers in Immunology

TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c66bdb06f8ca80b4848c5c18173437
http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00505/full

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Developmental gonadal expression of the transcription factor SET and its target gene, P450c17 (17alpha-hydroxylase/c17,20 lyase)

Autor: Nathalie A. Compagnone, Peilin Zhang, Jean-Louis Vigne, Thomas J. Musci, Synthia H. Mellon, Patricia A. Culp, Christelle Fiore

Publikováno v: DNA and cell biology. 20(10)

Cytochrome P450c17 catalyzes the 17alpha-hydroxylase/17,20 lyase activity needed for sex steroid synthesis. We recently characterized the nuclear phosphoprotein SET as a novel transcriptional regulator that binds to the -447/-399 region of the rat P4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e790815f4388f935db3e09cfa157f2ee
https://pubmed.ncbi.nlm.nih.gov/11749720

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c-mos and cdc2 Cooperate in the Translational Activation of Fibroblast Growth Factor Receptor-1 during Xenopus Oocyte Maturation

Autor: Patricia A. Culp, Thomas J. Musci

During oocyte maturation in Xenopus, previously quiescent maternal mRNAs are translationally activated at specific times. We hypothesized that the translational recruitment of individual messages is triggered by particular cellular events and investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6266a6cd4574440a64260e4f0d623c8e
https://europepmc.org/articles/PMC25638/

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The effect of vanadate on human kidney potassium dependent phosphatase

Autor: Clinton N. Corder, Gary L. Nieder, Patricia A. Culp

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 307:191-197

This study examined the effects of vanadate on the potassium dependent phosphatase activity present in purified human kidney microsomal (Na+ + K+)-adenosine triphosphatase. Vanadate anion inhibited the K+-dependent phosphatase at a K1 of 35 nM. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6f3eb6e6ff61639ba846e8ce436155
https://doi.org/10.1007/bf00498463

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