Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Patricia A Champion"'
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0281564 (2024)
Retinoic acid inducible gene I (Rig-I) is a cytosolic pattern recognition receptor canonically described for its important role in sensing viral RNAs. Increasingly, bacterially-derived RNA from intracellular bacteria such as Mycobacterium tuberculosi
Externí odkaz:
https://doaj.org/article/c1d64d00e4c3423082f00305ec4efeb9
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010610 (2022)
Externí odkaz:
https://doaj.org/article/598ab8a4b14a4bfcb58390f58970140b
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009124 (2021)
Mycobacterial pathogens pose a sustained threat to human health. There is a critical need for new diagnostics, therapeutics, and vaccines targeting both tuberculous and nontuberculous mycobacterial species. Understanding the basic mechanisms used by
Externí odkaz:
https://doaj.org/article/cb022204bac0483da6f50be590b30e82
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/1fb773be8a184bff9eebc6d505faf966
Autor:
Owen A. Collars, Bradley S Jones, Daniel D Hu, Simon D Weaver, Matthew M Champion, Patricia A. Champion
Publikováno v:
bioRxiv
N-terminal protein acetylation is a ubiquitous post-translational modification that broadly impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36f5a3588e2e33247c676064ce76366
https://doi.org/10.1101/2023.03.14.532585
https://doi.org/10.1101/2023.03.14.532585
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Aruna R. Menon, Madeleine K. Jennisch, David M. Tobin, Patricia A. Champion
Publikováno v:
bioRxiv
Bacterial pathogens use protein secretion systems to translocate virulence factors into the host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion system facilitates disruption of the macrophage phagosome during infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be6350a29983cb99cce050ce4e1bc5
https://doi.org/10.1101/2023.02.15.528779
https://doi.org/10.1101/2023.02.15.528779
Autor:
Kevin G. Sanchez, Rebecca J. Prest, Kathleen R. Nicholson, Konstantin V. Korotkov, Patricia A. Champion
Publikováno v:
J Bacteriol
Pathogenic mycobacteria use the ESX-1 secretion system to escape the macrophage phagosome and survive infection. We demonstrated that the ESX-1 system is regulated by feedback control in Mycobacterium marinum, a nontuberculous pathogen and model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97eb16559dd90b2d3cb7dd8abaeb7f68
https://europepmc.org/articles/PMC9765225/
https://europepmc.org/articles/PMC9765225/
Autor:
Joseph W. Saelens, Mollie I. Sweeney, Gopinath Viswanathan, Ana María Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, Rachel M. Cronin, Erika J. Hughes, W. Jared Brewer, Jörn Coers, Matthew M. Champion, Patricia A. Champion, Craig B. Lowe, Clare M. Smith, Sunhee Lee, Jason E. Stout, David M. Tobin
Publikováno v:
Cell
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting with unusually high rates of extrapulmonary dissemination and bone diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83917a2f0a20514c1f17e7753d9b41f9
https://europepmc.org/articles/PMC9691622/
https://europepmc.org/articles/PMC9691622/
Autor:
Rachel M, Cronin, Micah J, Ferrell, Clare W, Cahir, Matthew M, Champion, Patricia A, Champion
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(24)
The ESX-1 (ESAT-6-system-1) system and the protein substrates it transports are essential for mycobacterial pathogenesis. The precise ways that ESX-1 substrates contribute to virulence remains unknown. Several known ESX-1 substrates are also required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acba743e2744918c9c675f00dc782f07
https://pubmed.ncbi.nlm.nih.gov/35671426
https://pubmed.ncbi.nlm.nih.gov/35671426
Publikováno v:
Infant Mental Health Journal. 41:836-849
Premature birth has a well-documented impact on infants, mothers and their dyadic interactions. First time motherhood in the context of low risk premature birth-relatively unexplored in the literature-is a specific experience that sits at the nexus o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3397678975fe8237da73bde9a31adf73
https://doi.org/10.1002/imhj.21875
https://doi.org/10.1002/imhj.21875