Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patricia A, Loughran"'
Autor:
Ting Gong, Qing-De Wang, Patricia A. Loughran, Yue-Hua Li, Melanie J. Scott, Timothy R. Billiar, You-Tan Liu, Jie Fan
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-24 (2024)
Abstract Background Sepsis is often accompanied by lactic acidemia and acute lung injury (ALI). Clinical studies have established that high serum lactate levels are associated with increased mortality rates in septic patients. We further observed a s
Externí odkaz:
https://doaj.org/article/df73bae979534c3cb71de919c020e133
Autor:
Ting Gong, Yu Fu, Qingde Wang, Patricia A. Loughran, Yuehua Li, Timothy R. Billiar, Zongmei Wen, Youtan Liu, Jie Fan
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Sepsis-induced acute lung injury (ALI), characterized by severe hypoxemia and pulmonary leakage, remains a leading cause of mortality in intensive care units. The exacerbation of ALI during sepsis is largely attributed to uncontrolled inflam
Externí odkaz:
https://doaj.org/article/725525ba5e9849bf9772d559f864c2bc
Autor:
Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A. Loughran, Meihong Deng, Melanie J. Scott, Timothy R. Billiar
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-15 (2021)
Abstract Background Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown to suppress I/R injur
Externí odkaz:
https://doaj.org/article/fe043631ecec4fa29a132c60c1ebe4c2
Autor:
Wenbo Li, Meihong Deng, Patricia A. Loughran, Muqing Yang, Minjie Lin, Chenxuan Yang, Wentao Gao, Shuqing Jin, Shilai Li, Jingjing Cai, Ben Lu, Timothy R. Billiar, Melanie J. Scott
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of lethality when released extracellularly during sepsis. The major source of circulating HMGB1 in sepsis is hepatocytes. However, the mechanism of HMGB1 release
Externí odkaz:
https://doaj.org/article/6c5999b99daf48be9c3b581749eb21c1
Autor:
Hui Zhou, Meihong Deng, Yingjie Liu, Chenxuan Yang, Rosemary Hoffman, Jingjiao Zhou, Patricia A. Loughran, Melanie J. Scott, Matthew D. Neal, Timothy R. Billiar
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 638-648 (2018)
Abstract: Thrombocytopenia impairs host defense and hemostasis in sepsis. However, the mechanisms of how platelets regulate host defense are not fully understood. High-mobility group box 1 (HMGB1), a danger-associated molecular pattern protein, is re
Externí odkaz:
https://doaj.org/article/831979ce75554e1faf0edee5c08d08c0
Autor:
Onome A, Oghifobibi, Andrew E, Toader, Melissa A, Nicholas, Brittany P, Nelson, Nicole G, Alindogan, Michael S, Wolf, Anthony E, Kline, Seyed M, Nouraie, Corina O, Bondi, Bistra, Iordanova, Robert Sb, Clark, Hülya, Bayır, Patricia A, Loughran, Simon C, Watkins, Claudette M, St Croix, Patrick M, Kochanek, Alberto L, Vazquez, Mioara D, Manole
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(12)
Epinephrine is the principal resuscitation therapy for pediatric cardiac arrest (CA). Clinical data suggest that although epinephrine increases the rate of resuscitation, it fails to improve neurological outcome, possibly secondary to reductions in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2f257f319a27554d95dad63ba2cc5e2
https://pubmed.ncbi.nlm.nih.gov/35854408
https://pubmed.ncbi.nlm.nih.gov/35854408
Autor:
Onome A Oghifobibi, Andrew E Toader, Melissa A Nicholas, Brittany P Nelson, Nicole G Alindogan, Michael S Wolf, Anthony E Kline, Seyed M Nouraie, Corina O Bondi, Bistra Iordanova, Robert SB Clark, Hülya Bayır, Patricia A Loughran, Simon C Watkins, Claudette M St Croix, Patrick M Kochanek, Alberto L Vazquez, Mioara D Manole
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:2255-2269
Epinephrine is the principal resuscitation therapy for pediatric cardiac arrest (CA). Clinical data suggest that although epinephrine increases the rate of resuscitation, it fails to improve neurological outcome, possibly secondary to reductions in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef7e2f951290a172d8d665482a90dfa
https://doi.org/10.1177/0271678x221113022
https://doi.org/10.1177/0271678x221113022
Autor:
Kent Zettel, Sebastian Korff, Ruben Zamora, Adrian E. Morelli, Sophie Darwiche, Patricia A. Loughran, Greg Elson, Limin Shang, Susana Salgado-Pires, Melanie J. Scott, Yoram Vodovotz, Timothy R. Billiar
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Trauma combined with hemorrhagic shock (HS/T) leads to systemic inflammation, which results in organ injury. Toll-like Receptor 4 (TLR4)-signaling activation contributes to the initiation of inflammatory pathways following HS/T but its cell-specific
Externí odkaz:
https://doaj.org/article/7c7629ab89df48bb8074e3a61975ba03
Publikováno v:
Current Protocols. 2
Immunohistochemistry is an essential technique for the localization and measurement of proteins in cells and tissues. This article describes methods for labeling proteins in adherent and suspension cell cultures and in tissue sections. Choices of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b2b55efae0c725b2bd318f5733c6e8
https://doi.org/10.1002/cpz1.549
https://doi.org/10.1002/cpz1.549
Publikováno v:
Current protocolsLiterature Cited. 2(1)
The protocols presented here describe steps for cryosectioning tissue samples to be used in light microscopy methodologies including histochemistry, enzyme immunohistochemistry, and immunofluorescence. © 2022 Wiley Periodicals LLC. Basic Protocol 1:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be599dce2bd0629c8298ab141370eca3
https://pubmed.ncbi.nlm.nih.gov/35038380
https://pubmed.ncbi.nlm.nih.gov/35038380