Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Patricia A, Kosian"'
Publikováno v:
Toxicological Sciences. 193:192-203
A number of xenobiotics interfere with thyroid hormone (TH) signaling. Although adequate supplies of TH are necessary for normal brain development, regulatory reliance on serum TH as proxies for brain TH insufficiency is fraught with significant unce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eaa03dc547840a6e91332999f0cc880
https://doi.org/10.1093/toxsci/kfad040
https://doi.org/10.1093/toxsci/kfad040
Autor:
Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz
Publikováno v:
Toxicol Sci
Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb6524a19ef791df91df42dd10d0e95
https://doi.org/10.1093/toxsci/kfac014
https://doi.org/10.1093/toxsci/kfac014
Autor:
Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung
Publikováno v:
Toxicol Sci
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f2fa073d9a14784133cb3ac98477b
https://doi.org/10.1093/toxsci/kfaa036
https://doi.org/10.1093/toxsci/kfaa036
Publikováno v:
Golf Course Management & Construction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd4fef949b1e19c2c1a6d075100f251
https://doi.org/10.1201/9781003070092-7
https://doi.org/10.1201/9781003070092-7
Autor:
Joseph J. Korte, Jonathan T. Haselman, Patricia A. Kosian, Sigmund J. Degitz, Allen W. Olmstead
Publikováno v:
Aquatic Toxicology. 199:240-251
The Larval Amphibian Growth and Development Assay (LAGDA) is an internationally harmonized testing guideline for evaluating effects of chronic chemical exposure in amphibians. In order to evaluate the effects of chronic exposure to an antiandrogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6223443d5fa9922a2da4371af9ee67
https://doi.org/10.1016/j.aquatox.2018.03.013
https://doi.org/10.1016/j.aquatox.2018.03.013
Autor:
Mary E. Gilbert, Sigmund J. Degitz, Jermaine Ford, Patricia A. Kosian, Iman Hassan, Hisham A. El-Masri
Publikováno v:
Toxicological Sciences. 160:57-73
Adequate levels of thyroid hormone (TH) are needed for proper brain development, deficiencies may lead to adverse neurologic outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f232ece1ad3133e9a65604d4d91de58
https://doi.org/10.1093/toxsci/kfx163
https://doi.org/10.1093/toxsci/kfx163
Autor:
Jenna E. Cavallin, Gerald T. Ankley, Anthony L. Schroeder, Eric C. Randolph, Michael D. Kahl, Chad A. Blanksma, Daniel L. Villeneuve, Shane T. Poole, Patricia A. Kosian, Kellie A. Fay, Kathleen M. Jensen, Dries Knapen, Brett R. Blackwell, Lucia Vergauwen
Publikováno v:
Environmental Toxicology and Chemistry. 36:2942-2952
Inflation of the posterior and/or anterior swim bladder are processes previously demonstrated to be thyroid-hormone regulated. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically-active form, 3,5,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cfd654a650030419589f436517949f
https://doi.org/10.1002/etc.3855
https://doi.org/10.1002/etc.3855
Autor:
Patricia A. Kosian, Patricia K. Schmieder, Katie Challis, Nagaraju Dongari, Mark A. Tapper, Richard C. Kolanczyk, Barbara R. Sheedy, Tylor J. Lahren, Dean E. Hammermeister, Jose Serrano, Alena Kubátová
Publikováno v:
J Chromatogr B Analyt Technol Biomed Life Sci
Cyclic phenones are chemicals of interest to the USEPA and international organizations due to their potential for endocrine disruption to aquatic and terrestrial species. The metabolic conversion of cyclic phenones by liver hepatocytes and the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e40565b4c197a061dec94b1652af191
https://europepmc.org/articles/PMC6779324/
https://europepmc.org/articles/PMC6779324/
Autor:
Jose, Serrano, Mark A, Tapper, Richard C, Kolanczyk, Barbara R, Sheedy, Tylor, Lahren, Dean E, Hammermeister, Jeffrey S, Denny, Michael W, Hornung, Alena, Kubátová, Patricia A, Kosian, Jessica, Voelker, Patricia K, Schmieder
Publikováno v:
Xenobiotica
1. Cyclic phenones are chemicals of interest to the USEPA and international community due to their potential for endocrine disrupting activity. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e53dc9b3fec4de446856b1e69f946dd1
https://pubmed.ncbi.nlm.nih.gov/30888238
https://pubmed.ncbi.nlm.nih.gov/30888238
Autor:
Michael W. Hornung, Jessica Voelker, Tylor J. Lahren, Patricia K. Schmieder, Dean E. Hammermeister, Patricia A. Kosian, Mark A. Tapper, Jose Serrano, Alena Kubátová, Barbara R. Sheedy, Richard C. Kolanczyk, Jeffrey S. Denny
1. Cyclic phenones are chemicals of interest to the USEPA due to their potential for endocrine disruption to aquatic and terrestrial species. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b2b217c66f4c2a80cf270577040aaf