Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Patricia Melnyk"'
Autor:
Amélie Laversin, Robin Dufossez, Raphaël Bolteau, Romain Duroux, Séverine Ravez, Sergio Hernandez-Tapia, Martin Fossart, Mathilde Coevoet, Maxime Liberelle, Saïd Yous, Nicolas Lebègue, Patricia Melnyk
Publikováno v:
Molecules, Vol 29, Iss 16, p 3847 (2024)
The adenosine A2A receptor (A2AR) has been identified as a therapeutic target for treating neurodegenerative diseases and cancer. In recent years, we have highlighted the 2-aminoquinazoline heterocycle as an promising scaffold for designing new A2AR
Externí odkaz:
https://doaj.org/article/a703fdddfb0a4440a94b3374b1f753d3
Autor:
Jean-Pierre Armand, Marie-Priscille Brun, Janine Cossy, Joël Doré, Philippe Duchateau, Gérard Guillamot, Jean-François Haeuw, Patricia Melnyk, Alexandre Pachot, Sophie Postel-Vinay, Raphaël Rodriguez, Nathalie Strub-Wourgaft, Bruno Villoutreix, Bernard Meunier
Acteurs ou bénéficiaires, nous sommes tous spectateurs sidérés de l'ampleur des progrès de la médecine. Ils sont la conséquence des découvertes du XXe siècle, en particulier sur la biologie moléculaire et le génome. La recherche du XXIe si
Autor:
Sylvain Marc, Christophe Mésangeau, Mathilde Coevoet, Amélie Barczyk, Stéphane Burlet, Philippe Verwaerde, Cecilia Estrella, Cyrille Brantis, Nicolas Sergeant, Pascal Carato, Patricia Melnyk
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100020- (2022)
Alzheimer's disease is a complex and multifactorial disease characterized by extracellular Aβ peptide deposits related to the deregulation of APP metabolism, intracellular aggregation of hyper and abnormally phosphorylated isoforms of Tau proteins,
Externí odkaz:
https://doaj.org/article/d04e48aff8dd43daab307fe1dceece4c
Autor:
Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet, Nicolas Lebegue
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 524-538 (2020)
A series of nitrogen heterocycles containing α–ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-one was the most toler
Externí odkaz:
https://doaj.org/article/675e141641d84b13babe4e8932ee3515
Autor:
Pasquale Sileo, Clémence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotelle
Publikováno v:
Cells, Vol 11, Iss 22, p 3631 (2022)
The Hippo pathway consists of a cascade of kinases that controls the phosphorylation of the co-activators YAP/TAZ. When unphosphorylated, YAP and TAZ translocate into the nucleus, where they mainly bind to the TEAD transcription factor family and act
Externí odkaz:
https://doaj.org/article/88352385c66045fe8c08001e4d4ad092
Autor:
Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Jamal El Bakali, Liesel Mary Goveas, Mélanie Dumoulin, Chloé Lamarre, David Blum, Luc Buée, Patricia Melnyk, Nicolas Sergeant
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes. An in-depth structure–activity
Externí odkaz:
https://doaj.org/article/8935d38d81d34dc79eee67e56e27fe2a
Autor:
Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melnyk
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 217-233 (2019)
Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment. Today, only symptomatic drugs are available and therapeutic treatments, possibly acting at
Externí odkaz:
https://doaj.org/article/81981f930cdb439bb251f4f9165c75b8
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 224-229 (2019)
Using histamine as lead molecule, a library of (hetero)aryl substituted thiazol-2,4-yl derivatives incorporating pyridine as proton shuttling moiety were obtained and investigated as activators of human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I,
Externí odkaz:
https://doaj.org/article/e55317ea4e174352b997ce004b41d544
Autor:
Antoine Marchand, Alessia Sarchione, Panagiotis S. Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, Romain Magnez, Matthieu Drouyer, Marco Emanuele, Franz Y. Ho, Maxime Liberelle, Patricia Melnyk, Nicolas Lebègue, Xavier Thuru, R. Jeremy Nichols, Elisa Greggio, Arjan Kortholt, Thierry Galli, Marie-Christine Chartier-Harlin, Jean-Marc Taymans
Publikováno v:
Cells, Vol 11, Iss 6, p 1018 (2022)
The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and Kinase, involved in intracellular signaling and trafficki
Externí odkaz:
https://doaj.org/article/18bf45a023c0403281af9f78d80acdf0
Autor:
Raphael Rapetti-Mauss, Jérémy Nigri, Camille Berenguier, Pascal Finetti, Sarah Simha Tubiana, Bonnie Labrum, Benoit Allegrini, Bernard Pellissier, Georgios Efthymiou, Zainab Hussain, Corinne Bousquet, Nelson Dusetti, François Bertucci, Hélène Guizouarn, Patricia Melnyk, Franck Borgese, Richard Tomasini, Olivier Soriani
Publikováno v:
Gut. 72:722-735
ObjectiveIntercellular communication within pancreatic ductal adenocarcinoma (PDAC) dramatically contributes to metastatic processes. The underlying mechanisms are poorly understood, resulting in a lack of targeted therapy to counteract stromal-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2c19f6fb6f83e6ec97a49ca322dba56
https://doi.org/10.1136/gutjnl-2021-326610
https://doi.org/10.1136/gutjnl-2021-326610