Zobrazeno 1 - 10 of 732 pro vyhledávání: '"Patricia LoRusso"'
1
Akademický článek
First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budigalimab in patients with advanced solid tumors
Autor: Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Anthony Tolcher
Publikováno v: Frontiers in Oncology, Vol 14 (2024)
BackgroundTransforming growth factor (TGF)-ß1 is a pleiotropic cytokine that can promote tumor growth and suppress antitumor immune responses. Latent TGF-ß1 associates with glycoprotein-A repetition predominant (GARP) on the surface of regulatory T
Externí odkaz: https://doaj.org/article/ecaf119bc00648e1807c616981421d5c
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2
Akademický článek
A crisis in clinical research
Autor: Mario Sznol, Patricia LoRusso, David S Hong
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
The clinical research pipeline is critical to ensuring continued development of novel treatments that can offer patients with cancer safe and effective options. Unfortunately, progress has slowed since the COVID-19 pandemic due to uncovered, systemic
Externí odkaz: https://doaj.org/article/411006a42ab147bf8691be7123885805
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3
Akademický článek
The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results
Autor: Gail D. Lewis, Guangmin Li, Jun Guo, Shang-Fan Yu, Carter T. Fields, Genee Lee, Donglu Zhang, Peter S. Dragovich, Thomas Pillow, BinQing Wei, Jack Sadowsky, Douglas Leipold, Tim Wilson, Amrita Kamath, Michael Mamounas, M. Violet Lee, Ola Saad, Voleak Choeurng, Alexander Ungewickell, Sharareh Monemi, Lisa Crocker, Kevin Kalinsky, Shanu Modi, Kyung Hae Jung, Erika Hamilton, Patricia LoRusso, Ian Krop, Melissa M. Schutten, Renee Commerford, Mark X. Sliwkowski, Eunpi Cho
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan. To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzuma
Externí odkaz: https://doaj.org/article/654b41b090ea4a87be21fb42ec554dae
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6
Akademický článek
A pilot study of volumetric and density tumor analysis of ACC patients treated with vorinostat in a phase II clinical trial
Autor: Molly Malarkey, Alex P. Toscano, Mohammad Hadi Bagheri, Jeffrey Solomon, Laura B. Machado, Patricia LoRusso, Alice Chen, Les R. Folio, Priscila H. Goncalves
Publikováno v: Heliyon, Vol 9, Iss 8, Pp e18680- (2023)
Rationale and objectives: Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer. The vast majority of clinical trials evaluating systemic therapy efficacy in solid tumors use the Response Evaluation Criteria in Solid Tumors (RECIST) to measu
Externí odkaz: https://doaj.org/article/4903f5df6a0143c682fa994fdeca01ec
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