Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patricia, Umlandt"'
Autor:
Jeffrey Lam, Marion van den Bosch, Joanna Wegrzyn, Jeremy Parker, Rawa Ibrahim, Kate Slowski, Linda Chang, Sergio Martinez-Høyer, Gianluigi Condorelli, Mark Boldin, Yu Deng, Patricia Umlandt, Megan Fuller, Aly Karsan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Myelodysplastic syndrome (MDS) is characterized by altered hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) regulation and reduction of miR-143 and miR-145 in some subtypes. Here the authors show that miR-143/145 loss leads to HS
Externí odkaz:
https://doaj.org/article/790c5842cee2493c94acd0bef130e50e
Autor:
Patrick Coulombe, Grigorios N. Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H. Kyle, Andrew I. Minchinton, R. Keith Humphries, Pamela A. Hoodless, Jeremy D.K. Parker, Joanne L. Wright, Aly Karsan
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1769-1780.e4 (2019)
Summary: The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1−/− mice, which die in the perinatal period due to respiratory distress. Constitutive or e
Externí odkaz:
https://doaj.org/article/7da597faf600423285c07b09a097bc00
Autor:
Aly Karsan, Andrew I. Minchinton, Jade Tong, Erika Diaz, Jennifer H.E. Baker, Patricia Umlandt, Alastair H. Kyle, Rebecca Shaw, Grigorios Paliouras, Fred Wong, Linda Chang, Megan Fuller, Alexandre Patenaude
Notch signaling is important for tumor angiogenesis induced by vascular endothelial growth factor A. Blockade of the Notch ligand Dll4 inhibits tumor growth in a paradoxical way. Dll4 inhibition increases endothelial cell sprouting, but vessels show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6916666585f5454ac4613b9ed0a48c8
https://doi.org/10.1158/0008-5472.c.6505830
https://doi.org/10.1158/0008-5472.c.6505830
Autor:
Aly Karsan, Andrew I. Minchinton, Jade Tong, Erika Diaz, Jennifer H.E. Baker, Patricia Umlandt, Alastair H. Kyle, Rebecca Shaw, Grigorios Paliouras, Fred Wong, Linda Chang, Megan Fuller, Alexandre Patenaude
PDF file - 3357K, Figure S1. DnMAML-mediated EC-specific Notch blockade inhibits larger vessel function. Figure S2. Flow cytometry analysis of PDGFRβ in LLC-VEGFA tumors of control and double Tg. Figure S3. NO production in the microvasculature of L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e5d56210438afc365a09ce5fdd0228
https://doi.org/10.1158/0008-5472.22401330
https://doi.org/10.1158/0008-5472.22401330
Autor:
Agatha N. Jassem, Natalie Prystajecky, Fawziah Marra, Pamela Kibsey, Kennard Tan, Patricia Umlandt, Loretta Janz, Sylvie Champagne, Bruce Gamage, George R. Golding, Michael R. Mulvey, Bonnie Henry, Linda M. N. Hoang
Publikováno v:
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2016 (2016)
Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in Bri
Externí odkaz:
https://doaj.org/article/3ad9a93de9554c67bf359b3d69e2144d
Autor:
Austin G. Kulasekararaj, Martin Jädersten, Patricia Umlandt, Jihong Jiang, Aly Karsan, Sergio Martinez-Høyer, Megan Fuller, Uwe Platzbecker, Nadia Gharaee, Luca Malcovati, T. Roderick Docking, Eva Hellström-Lindberg, Yu Deng, Angela Mo, Alan F. List, Jenny Li, Jeremy Parker
Publikováno v:
Nature Cell Biology, 22(5), 526-533. Nature Publishing Group
Interstitial deletion of the long arm of chromosome 5 (del(5q)) is the most common structural genomic variant in myelodysplastic syndromes (MDS)1. Lenalidomide (LEN) is the treatment of choice for patients with del(5q) MDS, but half of the responding
Autor:
Patricia Umlandt, Linda Chang, Melody Lu, Jeremy Parker, Megan Fuller, Joanna Wegrzyn-Woltosz, Aly Karsan, Jenny Li, Jeffrey C. F. Lam, Aparna Gopal, Rawa Ibrahim
Activation of inflammatory pathways is associated with bone marrow failure syndromes, but how specific molecules impact on the marrow microenvironment is not well elucidated. We report a novel role for the miR-145 target, Toll/Interleukin-1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab03d8a626bc0630fa0c428898cc251
Autor:
Mark Boldin, Linda Chang, Gianluigi Condorelli, Joanna Wegrzyn, Megan Fuller, Jeffrey C. F. Lam, Sergio Martinez-Høyer, Marion van den Bosch, Jeremy Parker, Yu Deng, Kate Slowski, Rawa Ibrahim, Patricia Umlandt, Aly Karsan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Expression of miR-143 and miR-145 is reduced in hematopoietic stem/progenitor cells (HSPCs) of myelodysplastic syndrome patients with a deletion in the long arm of chromosome 5. Here we show that mice lacking miR-143/145 have impaired HSPC activity w
Autor:
Jenny Li, Melody Lu, Megan Fuller, Aly Karsan, Aparna Gopal, Linda Ya-Ting Chang, Jeremy Parker, Rawa Ibrahim, Patricia Umlandt, Jeff Lam, Jessica Tran
Publikováno v:
Blood. 138:2169-2169
The myelodysplastic syndrome (MDS) are a group of hematological malignancies with the propensity to develop into either acute myeloid leukemia (AML) or bone marrow failure (BMF). Dysregulation of immune and inflammatory responses has been implicated
Autor:
Sergio, Martinez-Høyer, Yu, Deng, Jeremy, Parker, Jihong, Jiang, Angela, Mo, T Roderick, Docking, Nadia, Gharaee, Jenny, Li, Patricia, Umlandt, Megan, Fuller, Martin, Jädersten, Austin, Kulasekararaj, Luca, Malcovati, Alan F, List, Eva, Hellström-Lindberg, Uwe, Platzbecker, Aly, Karsan
Publikováno v:
Nature cell biology. 22(5)
Interstitial deletion of the long arm of chromosome 5 (del(5q)) is the most common structural genomic variant in myelodysplastic syndromes (MDS)