Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Patricia, Melnyk"'
Autor:
Amélie Laversin, Robin Dufossez, Raphaël Bolteau, Romain Duroux, Séverine Ravez, Sergio Hernandez-Tapia, Martin Fossart, Mathilde Coevoet, Maxime Liberelle, Saïd Yous, Nicolas Lebègue, Patricia Melnyk
Publikováno v:
Molecules, Vol 29, Iss 16, p 3847 (2024)
The adenosine A2A receptor (A2AR) has been identified as a therapeutic target for treating neurodegenerative diseases and cancer. In recent years, we have highlighted the 2-aminoquinazoline heterocycle as an promising scaffold for designing new A2AR
Externí odkaz:
https://doaj.org/article/a703fdddfb0a4440a94b3374b1f753d3
Autor:
Jean-Pierre Armand, Marie-Priscille Brun, Janine Cossy, Joël Doré, Philippe Duchateau, Gérard Guillamot, Jean-François Haeuw, Patricia Melnyk, Alexandre Pachot, Sophie Postel-Vinay, Raphaël Rodriguez, Nathalie Strub-Wourgaft, Bruno Villoutreix, Bernard Meunier
Acteurs ou bénéficiaires, nous sommes tous spectateurs sidérés de l'ampleur des progrès de la médecine. Ils sont la conséquence des découvertes du XXe siècle, en particulier sur la biologie moléculaire et le génome. La recherche du XXIe si
Autor:
Marie Tautou, Florian Descamps, Paul-Emmanuel Larchanché, Luc Buée, Jamal El Bakali, Patricia Melnyk, Nicolas Sergeant
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5285 (2023)
The progress in Alzheimer’s disease (AD) treatment suggests a combined therapeutic approach targeting the two lesional processes of AD, which include amyloid plaques made of toxic Aβ species and neurofibrillary tangles formed of aggregates of abno
Externí odkaz:
https://doaj.org/article/ab94ded707414a969ec2795a4dbdcb2c
Autor:
Sylvain Marc, Christophe Mésangeau, Mathilde Coevoet, Amélie Barczyk, Stéphane Burlet, Philippe Verwaerde, Cecilia Estrella, Cyrille Brantis, Nicolas Sergeant, Pascal Carato, Patricia Melnyk
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100020- (2022)
Alzheimer's disease is a complex and multifactorial disease characterized by extracellular Aβ peptide deposits related to the deregulation of APP metabolism, intracellular aggregation of hyper and abnormally phosphorylated isoforms of Tau proteins,
Externí odkaz:
https://doaj.org/article/d04e48aff8dd43daab307fe1dceece4c
Autor:
Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet, Nicolas Lebegue
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 524-538 (2020)
A series of nitrogen heterocycles containing α–ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-one was the most toler
Externí odkaz:
https://doaj.org/article/675e141641d84b13babe4e8932ee3515
Autor:
Pasquale Sileo, Clémence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotelle
Publikováno v:
Cells, Vol 11, Iss 22, p 3631 (2022)
The Hippo pathway consists of a cascade of kinases that controls the phosphorylation of the co-activators YAP/TAZ. When unphosphorylated, YAP and TAZ translocate into the nucleus, where they mainly bind to the TEAD transcription factor family and act
Externí odkaz:
https://doaj.org/article/88352385c66045fe8c08001e4d4ad092
Autor:
Christophe Mesangeau, Pascal Carato, Nicolas Renault, Mathilde Coevoet, Paul-Emmanuel Larchanché, Amélie Barczyk, Luc Buée, Nicolas Sergeant, Patricia Melnyk
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13111 (2022)
The rationale to define the biological and molecular parameters derived from structure–activity relationships (SAR) is mandatory for the lead selection of small drug compounds. Several series of small molecules have been synthesized based on a comp
Externí odkaz:
https://doaj.org/article/21c2934020cd46449cb746c677310a28
Autor:
Bénédicte Oxombre, Fahima Madouri, Anne-Sophie Journé, Séverine Ravez, Eloise Woitrain, Pascal Odou, Nathalie Duhal, Sandro Ninni, David Montaigne, Nadira Delhem, Patrick Vermersch, Patricia Melnyk
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11893 (2022)
Multiple Sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of the central nervous system (CNS). Current management strategies suppress or modulate immune function, all with consequences and known side effects. They demonstra
Externí odkaz:
https://doaj.org/article/6c398fed2d04454fab0414efedc246c1
Autor:
Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Jamal El Bakali, Liesel Mary Goveas, Mélanie Dumoulin, Chloé Lamarre, David Blum, Luc Buée, Patricia Melnyk, Nicolas Sergeant
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes. An in-depth structure–activity
Externí odkaz:
https://doaj.org/article/8935d38d81d34dc79eee67e56e27fe2a
Autor:
Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melnyk
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 217-233 (2019)
Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment. Today, only symptomatic drugs are available and therapeutic treatments, possibly acting at
Externí odkaz:
https://doaj.org/article/81981f930cdb439bb251f4f9165c75b8