Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Patricia, Himmels"'
Autor:
Alessandra Castiglioni, Yagai Yang, Katherine Williams, Alvin Gogineni, Ryan S. Lane, Amber W. Wang, Justin A. Shyer, Zhe Zhang, Stephanie Mittman, Alan Gutierrez, Jillian L. Astarita, Minh Thai, Jeffrey Hung, Yeqing Angela Yang, Tony Pourmohamad, Patricia Himmels, Marco De Simone, Justin Elstrott, Aude-Hélène Capietto, Rafael Cubas, Zora Modrusan, Wendy Sandoval, James Ziai, Stephen E. Gould, Wenxian Fu, Yulei Wang, James T. Koerber, Shomyseh Sanjabi, Ira Mellman, Shannon J. Turley, Sören Müller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting tumors from excluded to inflamed
Externí odkaz:
https://doaj.org/article/fa5b40b8c1aa4ad3abed292446b9c3af
Autor:
Patricia Himmels, Isidora Paredes, Heike Adler, Andromachi Karakatsani, Robert Luck, Hugo H. Marti, Olga Ermakova, Eugen Rempel, Esther T. Stoeckli, Carmen Ruiz de Almodóvar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titratin
Externí odkaz:
https://doaj.org/article/1c485bbbb8e44bb3a721507f6d42678e
Autor:
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lélia Delamarre, Ira Mellman
Publikováno v:
Nature Immunology. 23:532-542
The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that the 'interleukin 1 (IL-1)-interleukin 1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853754e3429271261548c4c29dc649ea
https://doi.org/10.1038/s41590-022-01160-y
https://doi.org/10.1038/s41590-022-01160-y
Autor:
Antonina V. Kurtova, Melanie Heinlein, Simon Haas, Lars Velten, Gerrit J. P. Dijkgraaf, Elaine E. Storm, Noelyn M. Kljavin, Soufiane Boumahdi, Patricia Himmels, Aurelie Herault, Andrew Mancini, Hartmut Koeppen, Monique Dail, Qingxiang Yan, Jianhuan Zhang, Ute Koch, Freddy Radtke, Zora Modrusan, Ciara Metcalfe, Robert Piskol, Frederic J. de Sauvage
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b308255afe28c772497cb21827be407c
http://edoc.mdc-berlin.de/21971/2/21971suppl.pdf
http://edoc.mdc-berlin.de/21971/2/21971suppl.pdf
Autor:
Patricia Himmels, Thi Thu Thao Nguyen, Maresa Caunt Mitzner, Alfonso Arrazate, Stacey Yeung, Jeremy Burton, Robyn Clark, Klara Totpal, Raj Jesudason, Angela Yang, Margaret Solon, Jeffrey Eastham, Zora Modrusan, Joshua D Webster, Amy A Lo, Robert Piskol, Weilan Ye
Publikováno v:
EMBO reports. 24
Preclinical and clinical studies demonstrate that T cell-dependent bispecific antibodies (TDBs) induce systemic changes in addition to tumor killing, leading to adverse events. Here, we report an in-depth characterization of acute responses to TDBs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cd1e6ca880bce795ec4e23014b8067
https://doi.org/10.15252/embr.202255532
https://doi.org/10.15252/embr.202255532
Autor:
José Ricardo, Vieira, Bhavin, Shah, Sebastian, Dupraz, Isidora, Paredes, Patricia, Himmels, Géza, Schermann, Heike, Adler, Alessia, Motta, Lea, Gärtner, Ariadna, Navarro-Aragall, Elena, Ioannou, Elena, Dyukova, Remy, Bonnavion, Andreas, Fischer, Dario, Bonanomi, Frank, Bradke, Christiana, Ruhrberg, Carmen, Ruiz de Almodóvar
Publikováno v:
Neuron 110(24), 4074-4089.e6 (2022). doi:10.1016/j.neuron.2022.12.005
How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and endothelial cells (ECs), necessar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5097d00d3d38d8643651efba19a1ce7
https://doi.org/10.1016/j.neuron.2022.12.005
https://doi.org/10.1016/j.neuron.2022.12.005
Autor:
Ira Mellman, Siri Tahtinen, Leesun Kim, Ugur Sahin, Patricia Himmels, Yoko Oei, Andres Paler-Martinez, Jill Schartner, Emily C. Freund, Craig Blanchette, Weilan Ye, Benjamin Haley, Ann-Jay Tong, Sara Wichner, Cecile de la Cruz, Jaehak Oh, Mahesh Yadav, Mark McCarron, Lélia Delamarre, Zhainib Adel Amir
Excessive systemic inflammation is characteristic to various acute conditions including sepsis, viral infections and immunotherapy-induced adverse events such as cytokine release syndrome (CRS). Recently, several clinical trials evaluating variants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2e7afb3cdd01228b8c45dad26e9d7b
https://doi.org/10.21203/rs.3.rs-378991/v1
https://doi.org/10.21203/rs.3.rs-378991/v1
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42365 (2012)
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons. Although indir
Externí odkaz:
https://doaj.org/article/7af5fb7680734b54b84c90cbb5d59a6f
Publikováno v:
Developmental Cell. 45:10-32
A precise communication between the nervous and the vascular systems is crucial for proper formation and function of the central nervous system (CNS). Interestingly, this communication does not only occur by neural cells regulating the growth and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d9f042eff683af23427c0b9e5ebc9b
https://doi.org/10.1016/j.devcel.2018.01.023
https://doi.org/10.1016/j.devcel.2018.01.023
Autor:
Joshua D. Webster, Patricia Himmels, Lélia Delamarre, Kevin Walsh, Stephen E. Gould, Ismail Sergin, Hua Zhang, Aude-Hélène Capietto, Erin McNamara, Weilan Ye, Emel Esen, Min Xu, Robert Piskol, Rajiv Jesudason
Publikováno v:
Science immunology. 5(45)
During cytotoxic T cell activation, lymphocyte function-associated antigen-1 (LFA-1) engages its ligands on antigen-presenting cells (APCs) or target cells to enhance T cell priming or lytic activity. Inhibiting LFA-1 dampens T cell-dependent symptom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5feffcb4f9ce509ec95fbdad693dbdc
https://pubmed.ncbi.nlm.nih.gov/32220977
https://pubmed.ncbi.nlm.nih.gov/32220977