Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Patrice M. Milos"'
Autor:
Ankur Sharma, Christine Huard, Cecile Vernochet, Daniel Ziemek, Kelly M Knowlton, Edyta Tyminski, Theresa Paradis, Ying Zhang, Jessica E C Jones, David von Schack, Christopher T Brown, Patrice M Milos, Anthony J Coyle, Frederic Tremblay, Robert V Martinez
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92608 (2014)
Brown adipose tissue (BAT) plays a pivotal role in promoting energy expenditure by the virtue of uncoupling protein-1 (UCP-1) that differentiates BAT from its energy storing white adipose tissue (WAT) counterpart. The clinical implication of "classic
Externí odkaz:
https://doaj.org/article/35e422420472415ea5da98951dbe7a46
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19287 (2011)
RNA Seq provides unparalleled levels of information about the transcriptome including precise expression levels over a wide dynamic range. It is essential to understand how technical variation impacts the quality and interpretability of results, how
Externí odkaz:
https://doaj.org/article/ea7b523df2d1441dae819e0ed87bde86
Autor:
Lee T Sam, Doron Lipson, Tal Raz, Xuhong Cao, John Thompson, Patrice M Milos, Dan Robinson, Arul M Chinnaiyan, Chandan Kumar-Sinha, Christopher A Maher
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17305 (2011)
The second wave of next generation sequencing technologies, referred to as single-molecule sequencing (SMS), carries the promise of profiling samples directly without employing polymerase chain reaction steps used by amplification-based sequencing (A
Externí odkaz:
https://doaj.org/article/13ff61c7893f4d63849587d01a0effd6
Autor:
Adrian Reich, Nathalie Oulhen, Joseph P. Campanale, Amro Hamdoun, Tal Raz, Patrice M. Milos, S. Zachary Swartz, Gary M. Wessel
Publikováno v:
Development
Development, 2014, 141 (16), pp.3134-42. ⟨10.1242/dev.110395⟩
Development, 2014, 141 (16), pp.3134-42. ⟨10.1242/dev.110395⟩
A crucial event in animal development is the specification of primordial germ cells (PGCs), which become the stem cells that create sperm and eggs. How PGCs are created provides a valuable paradigm for understanding stem cells in general. We find tha
Publikováno v:
Current Genetic Medicine Reports. 2:103-112
Sequencing of the exome, the protein-coding region of the human genome, has quickly grown into a new approach for clinical diagnosis of disease. Enabled by next- generation sequencing technologies, clinical exomes accompanied by clinical interpretati
Autor:
Philipp Kapranov, Patrice M. Milos, Zhaoqing Yang, Dmitry Shtokalo, Georges St. Laurent, Michael R. Tackett, Yuri Vyatkin, Bernd Seilheimer, Timothy A. McCaffrey
Publikováno v:
Methods. 63:18-24
The analysis of the differential expression of genes has been the key goal of many molecular biology methods for decades and will remain with us for decades to come. It constitutes a fundamental resource at our disposal for determining the relationsh
Autor:
Tristen Ross, Anastasia Nikiforov, Rebecca Batorsky, Evan Mauceli, Marcia M. Nizzari, Niru Chennagiri, Alexander Frieden, Patrice M. Milos, Timothy W. Yu, Eric J. White, Daniel S. Lieber, Lovelace J. Luquette, Nichole Napolitano, Va Lip, John F. Thompson, Sherry Hansen, David H. Margulies, Edgardo Lopez
Publikováno v:
Scientific Reports
Next generation sequencing is a transformative technology for discovering and diagnosing genetic disorders. However, high-throughput sequencing remains error-prone, necessitating variant confirmation in order to meet the exacting demands of clinical
Autor:
Brinda Alagesan, Daniel A. Haber, Malgorzata E. Smas, David P. Ryan, Suchismita Paul, Gianmarco Contino, Nabeel Bardeesy, Min Yu, Brian W. Brannigan, Sridhar Ramaswamy, Fatih Ozsolak, Patrice M. Milos, Ben S. Wittner, Jordan C. Ciciliano, Mehmet Toner, David T. Ting, Daniel Winokur, Kristina Xega, Matthew J. Ulman, Anna J. Gilman, Lecia V. Sequist, Shannon L. Stott, Shyamala Maheswaran
Publikováno v:
Nature
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. Although these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne disse
Autor:
Jie He, Biao Dong, Adrian R. Moore, Patrice M. Milos, Debra Dederich, Philipp Kapranov, Kathleen E. Steinmann, Weidong Xiao, John F. Thompson, Lingxia Chen
Publikováno v:
Human Gene Therapy. 23:46-55
The single-stranded genome of adeno-associated viral (AAV) vectors is one of the key factors leading to slow-rising but long-term transgene expression kinetics. Previous molecular studies have established what is now considered a textbook molecular m
Autor:
Kristen Kerouac, Patrice M. Milos, Philipp Kapranov, Avak Kahvejian, Erik Hansen, Kathleen E. Steinmann, Jeffrey G. Reifenberger, Jaime Gill, Eldar Giladi, John F. Thompson, Doron Lipson, Travis Knope
Publikováno v:
Genome Research. 22:340-345
Genetic testing for disease risk is an increasingly important component of medical care. However, testing can be expensive, which can lead to patients and physicians having limited access to the genetic information needed for medical decisions. To si