Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrice Koza"'
Autor:
Patrice Koza, Franck Lach
Publikováno v:
ACS Combinatorial Science. 14:491-495
We developed an efficient one-pot tandem carbamoyl chloride amination and palladium-catalyzed intramolecular urea cyclization, which furnished high-throughput access to imidazo[4,5-b]pyridine-2-one and related imidazo[4,5-c]pyridine-2-one ring system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c24d2a8d92585d4d560b4af19ee9cc
https://doi.org/10.1021/co300078f
https://doi.org/10.1021/co300078f
Publikováno v:
ACS Combinatorial Science. 14:273-279
Preparative RP-LCMS is widely used to purify compounds from crude reaction mixtures in drug discovery today. Method development for preparative Liquid Chromatography-Mass Spectrometry (LCMS) consists of finding the right balance between speed and qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd10c11a84b15abc73786278199d5ee
https://doi.org/10.1021/co200197b
https://doi.org/10.1021/co200197b
Autor:
Frederic Henri Jung, Arnaud Stevenin, Sébastien L. Degorce, Patrice Koza, Jonathan Lecoq, Craig S. Harris
Publikováno v:
Tetrahedron Letters. 52:6719-6722
The synthesis of differentially-substituted 3,5-bis(arylamino)pyrazoles has not yet been documented. During our investigation, we managed to develop a novel, entirely combinatorial synthesis of 3,5-bis(arylamino)pyrazoles relying on a simple one-pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e8be7465ac56bd3d2dc2be9a27369e
https://doi.org/10.1016/j.tetlet.2011.09.150
https://doi.org/10.1016/j.tetlet.2011.09.150
Publikováno v:
Synthesis. 2011:2431-2436
The use of palladium(0) enables a highly regioselective C-2 aminationof 4,6-dichloronicotinonitrile. Coupling with aminoarenes that are N-acetyl-masked to limit cross-couplingoverreaction, leads to 4-chloro-6-anilino nicotinonitrile compoundsafter de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bcc154ee9a4e94d16e8b718730392f2
https://doi.org/10.1055/s-0030-1260080
https://doi.org/10.1055/s-0030-1260080
Publikováno v:
Tetrahedron. 55:7221-7232
An acid-sensitive linker for the solid phase synthesis of hydroxamic acids is described. Hydroxamic acid based TNFα inhibitors have been prepared by solid phase synthesis: derivatisation of N2-[4-(N-oxyamino)-2R-isobutyl-3S-aminosuccinyl]-L-tert-leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa8749b6b41b87a1bb0b5fff9ee9eea5
https://doi.org/10.1016/s0040-4020(99)00347-6
https://doi.org/10.1016/s0040-4020(99)00347-6
Publikováno v:
ChemInform. 42
N-Acetyl-masked aromatic and heteroaromatic amines are used to limit a cross-linking overreaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fe4aed9683b5ecb62787337836b36b7
https://doi.org/10.1002/chin.201149134
https://doi.org/10.1002/chin.201149134
Autor:
Craig S. Harris, Jacques Pelleter, Patrice Koza, Christine Lambert-van der Brempt, Olivier A. Willerval, Laurent Francois Andre Hennequin, Christian Delvare
Publikováno v:
ACS combinatorial science. 13(5)
The partnership between rational synthesis design and mass-triggered preparative LCMS is a powerful one, capable of furnishing very large libraries in a selective manner in a very short space of time. Herein, we communicate one example of possibly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08c1438c04a8806c819b4db601a3de4
https://pubmed.ncbi.nlm.nih.gov/21648463
https://pubmed.ncbi.nlm.nih.gov/21648463