Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Patrice E Poubelle"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109256 (2014)
IL-32γ is a multifunctional cytokine involved in various inflammatory and auto-immune diseases in which neutrophils can affect the evolution of these diseases. To persist at inflammatory sites, neutrophils require inhibition of their rapid and const
Externí odkaz:
https://doaj.org/article/d9682cb3dc804d9ca71da72c85959249
Autor:
Patrice E. Poubelle, Nathalie Pagé, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier, Martin Pelletier
Publikováno v:
Clinical and Translational Medicine, Vol 8, Iss 1, Pp 1-10 (2019)
Abstract Background Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic pre
Externí odkaz:
https://doaj.org/article/2b22c7caa26e48a6ac4cd3716497fc4c
Publikováno v:
The Journal of Immunology. 206:1943-1956
The concept of plasticity of neutrophils is highlighted by studies showing their ability to transdifferentiate into APCs. In this regard, transdifferentiated neutrophils were found at inflammatory sites of autoimmune arthritis (AIA). Exposure of neut
Publikováno v:
Journal of Leukocyte Biology. 108:647-657
Our knowledge of the role of cytokines in pathologic conditions has increased considerably with the emergence of molecular and genetic studies, particularly in the case of autoinflammatory monogenic diseases. Many rare disorders, considered orphan un
Autor:
Chenqi Zhao, Anne Sardella, Jerold Chun, Patrice E. Poubelle, Maria J. Fernandes, Sylvain G. Bourgoin
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1307-1318 (2011)
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid present in low concentrations in serum and biological fluids but in high concentrations at sites of inflammation. LPA evokes a variety of cellular responses via binding to and activation of
Externí odkaz:
https://doaj.org/article/23a733d2d2db454e95627c3fec29e49e
Autor:
Chenqi Zhao, Maria J. Fernandes, Mélanie Turgeon, Sabrina Tancrède, John Di Battista, Patrice E. Poubelle, Sylvain G. Bourgoin
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 11, Pp 2323-2337 (2008)
Sphingosine-1-phosphate (S1P), via interaction with its G protein-coupled receptors, regulates various physiological and pathological responses. The present study investigated the role of S1P/S1P receptor signaling in several functional responses of
Externí odkaz:
https://doaj.org/article/56280662c4524830b9d62c13c2816a4f
Publikováno v:
Toxicology in Vitro. 60:76-86
Apoptosis of neutrophils is an essential checkpoint for the resolution of inflammation by shutting down the deleterious functions of these immune cells. This study investigated the role of anhydroglucitol-core gallotannins (ACGs) in apoptosis increas
Autor:
Marie-Pier Longchamps, Philippe A. Tessier, Patrice E. Poubelle, Martin Pelletier, David B. Beck, Natalia Sampaio Moura, Nathalie Pagé, Ivona Aksentijevich
Publikováno v:
Clinical and Translational Medicine, Vol 8, Iss 1, Pp 1-10 (2019)
Clinical and Translational Medicine
Clinical and Translational Medicine
Background Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic predictors a
Autor:
Paul R. Fortin, Lynn Davis, Eric Boilard, Chenqi Zhao, Stephan Hasse, Myriam Vaillancourt, Sylvain G. Bourgoin, Yang Zhao, John A. Di Battista, Patrice E. Poubelle
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12685
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12685, p 12685 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12685, p 12685 (2021)
Lysophosphatidylserine (lysoPS) is known to regulate immune cell functions. Phospholipase A1 member A (PLA1A) can generate this bioactive lipid through hydrolysis of sn-1 fatty acids on phosphatidylserine (PS). PLA1A has been associated with cancer m
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Parathyroid hormone (PTH) can be C-terminally extended without significant affinity loss for the PTH1 receptor (PTHR1). We developed fusion protein ligands with enzymatic activity to probe PTHR1s at the cell surface. Two fusion proteins were generate