The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology

Autor: Georgina Chapman, Ushananthini Shanmugalingam, Patrice D. Smith

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2020)

Pentraxins are a superfamily of evolutionarily conserved proteins that are characterized by their multimeric architecture and their calcium-dependent binding. They can be broadly grouped into two subfamilies: short pentraxins and long pentraxins. Pen

Externí odkaz: https://doaj.org/article/ba1bdb031eaa4cd0add17a4f7a9749e7

B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke

Autor: Nafisa M. Jadavji, Joshua T. Emmerson, Amanda J. MacFarlane, William G. Willmore, Patrice D. Smith

Publikováno v: Neurobiology of Disease, Vol 103, Iss , Pp 89-100 (2017)

Folates are B-vitamins that play an important role in brain function. Dietary and genetic deficiencies in folate metabolism result in elevated levels of homocysteine which have been linked to increased risk of developing a stroke. Reducing levels of

Externí odkaz: https://doaj.org/article/e361eb3a070c4d63b49eceb85d249358

It's All about Timing: The Involvement of Kir4.1 Channel Regulation in Acute Ischemic Stroke Pathology

Autor: Meagan Milton, Patrice D. Smith

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

An acute ischemic stroke is characterized by the presence of a blood clot that limits blood flow to the brain resulting in subsequent neuronal loss. Acute stroke threatens neuronal survival, which relies heavily upon proper function of astrocytes. Ne

Externí odkaz: https://doaj.org/article/2c32e47f43d54b8e8ce6ba2e340ad63b

Potential roles of branched-chain amino acids in neurodegeneration

Autor: Hyung-Suk Yoo, Ushananthini Shanmugalingam, Patrice D. Smith

Publikováno v: Nutrition (Burbank, Los Angeles County, Calif.).

Despite having disease-specific pathologic features and symptoms, neurodegenerative diseases share common mechanisms, such as excitotoxicity, neuroinflammation, and neurotransmitter dysregulation. Although the common underlying cause of these neurode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90d980e0b85e601a22762a478a09d0b
https://pubmed.ncbi.nlm.nih.gov/35843039

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

Autor: Charles ffrench-Constant, Craig S Pearson, Amanda C. Barber, Keith R Martin, Bart Nieuwenhuis, Tasneem Z Khatib, Patrice D. Smith, Rachel S Evans, Lianne A Hulshof, Joachim Fuchs, Richard Eva, Klaus Okkenhaug, Raquel D. Conceição, Sarita S Deshpande, Britta J. Eickholt, Andrew Osborne, Joshua Cave, James W. Fawcett, Barbara Haenzi, Susan van Erp, Amy R. MacQueen

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
Nieuwenhuis, B, Barber, A C, Evans, R S, Pearson, C S, Fuchs, J, MacQueen, A R, van Erp, S, Haenzi, B, Hulshof, L A, Osborne, A, Conceicao, R, Khatib, T Z, Deshpande, S S, Cave, J, Ffrench-Constant, C, Smith, P D, Okkenhaug, K, Eickholt, B J, Martin, K R, Fawcett, J W & Eva, R 2020, ' PI 3-kinase delta enhances axonal PIP 3 to support axon regeneration in the adult CNS ', EMBO Molecular Medicine, vol. 12, no. 8, e11674 . https://doi.org/10.15252/emmm.201911674
EMBO Molecular Medicine, 12. Wiley-Blackwell

Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55745e26e27e0d2acf080ff3aaaf74ca
https://doi.org/10.15252/emmm.201911674