Photosensitisation by voriconazole-N-oxide results from a sequence of solvent and pH-dependent photochemical and thermal reactions

Autor: João Sette Whitaker Ferreira, Francisco Bosca, Jean-Claude Mazière, Artur M. S. Silva, René Santus, Patrice Morlière, Paulo Filipe, Raquel S. G. R. Seixas

Publikováno v: Journal of photochemistry and photobiology. B, Biology. 187

The phototoxicity of voriconazole (VN) prescribed in the treatment of severe fungal infections is frequently reported. Its major metabolite, a N-oxide derivative (VNO), was suspected to be the photosensitizer because it shows a maximum absorbance at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7037ee4afaefb3732bb33becef9f6010
https://pubmed.ncbi.nlm.nih.gov/30081214

A multi-omics analysis of the regulatory changes induced by miR-223 in a monocyte/macrophage cell line

Autor: Valérie Metzinger-Le Meuth, Ida Chiara Guerrera, Patrice Morlière, Roland Molinié, Laurent Metzinger, François Mesnard, Virginie Nourry, Catherine Cerutti, Laurent Gutierrez, Eléonore M'Baya-Moutoula, Loïc Louvet, Ophélie Fourdinier, Ziad A. Massy

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2018, 1864 (8), pp.2664-2678. ⟨10.1016/j.bbadis.2018.05.010⟩
Biochimica et Biophysica Acta-Molecular Basis of Disease, 2018, 1864 (8), pp.2664-2678. ⟨10.1016/j.bbadis.2018.05.010⟩

We used a multi-omics approach to study the impact of over-expression and inhibition of the microRNA miR-223, a pleiotropic regulator of metabolic-related disease, in a monocyte-macrophage cell line. We analyzed the levels of proteins, mRNAs, and met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b2aba4567efd113132493b8379061b
https://pubmed.ncbi.nlm.nih.gov/29778662

On the repair of oxidative damage to apoferritin: a model study with the flavonoids quercetin and rutin in aerated and deaerated solutions

Autor: Paulo M. Filipe, Jean-Claude Mazière, M.-A. Conte, Larry K. Patterson, J.-P. Ducroix, René Santus, Jean-Louis Dupas, Patrice Morlière

Publikováno v: Free Radical Research. 47:463-473

Ferritin (Ft) impairment through (•)O2(-), H2O2, and (•)OH production occurs in the cases of ketoses, diabetes mellitus, acute intermittent porphyria and tyrosinemia. In addition to (•)Trp and TyrO(•) radical production, ferrous iron liberati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9fe589cb8d668fa7f4d4b04059057
https://doi.org/10.3109/10715762.2013.791024

Iron mobilization from ultraviolet-irradiated, iron-saturated, transferrin

Autor: Josiane Haigle, Patrice Morlière, M. Aubailly, René Santus, S. Salmon

Publikováno v: Redox report : communications in free radical research. 2(1)

Transferrin is the major iron transport protein of mammalian plasma. The ultraviolet-B irradiation of 1.4 mg/ml iron saturated transferrin solutions (~32 μM Fe(3+)) induces a Fe(3+) loss accompanied by Fe(2+) formation. The initial quantum yield of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e330f282d15b57d8d34939be4f714c1d
https://pubmed.ncbi.nlm.nih.gov/27414512

Uremic Toxin Indoxyl Sulfate Inhibits Human Vascular Smooth Muscle Cell Proliferation

Autor: Anaïs Mozar, Patrice Morlière, Ziad A. Massy, Tilman B. Drüeke, Loïc Louvet, Said Kamel, Cédric Boudot, Corinne Godin

Publikováno v: Therapeutic Apheresis and Dialysis. 15:135-139

Uremic syndrome is attributed to the progressive retention of a large number of compounds, such as indoxyl sulfate, which under physiological conditions are excreted by the kidneys. Previous in vitro studies have demonstrated that uremic indoxyl sulf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a24ece1798f4048f20d7f5a7de19c23e
https://doi.org/10.1111/j.1744-9987.2010.00885.x