Výsledky vyhledávání - "Patric J. D. Delhanty"

Akademický článek

In Vivo Effects of a GHR Synthesis Inhibitor During Prolonged Treatment in Dogs

Autor: Elpetra P. M. Timmermans, Joëlle Blankevoort, Guy C. M. Grinwis, Sietske J. Mesu, Ronette Gehring, Patric J. D. Delhanty, Peter E. M. Maas, Ger J. Strous, Jan A. Mol

Publikováno v: Pharmaceuticals, Vol 17, Iss 10, p 1381 (2024)

Background: The activation of the growth hormone receptor (GHR) is a major determinant of body growth. Defective GHR signaling, as seen in human Laron dwarfism, resulted in low plasma IGF-1 concentrations and limited growth, but also marked absence i

Externí odkaz: https://doaj.org/article/5b4489a9c71247ea899d31c04259ad42

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Akademický článek

Overweight and obesity in type 1 diabetes is not associated with higher ghrelin concentrations

Autor: Behiye Özcan, Patric J. D. Delhanty, Martin Huisman, Jenny A. Visser, Sebastian J. Neggers, Aart Jan van der Lely

Publikováno v: Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-7 (2021)

Abstract Background Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This stud

Externí odkaz: https://doaj.org/article/4a2f1cf6a22b4fc78f5d5f0ca9824136

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Akademický článek

Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition

Autor: Lotte E. Vlug, Patric J. D. Delhanty, Esther G. Neelis, Martin Huisman, Jenny A. Visser, Edmond H. H. M. Rings, René M. H. Wijnen, Sjoerd C. J. Nagelkerke, Merit M. Tabbers, Jessie M. Hulst, Barbara A. E. de Koning

Publikováno v: Frontiers in Nutrition, Vol 9 (2022)

BackgroundChildren with intestinal failure (IF) require parenteral nutrition (PN). Transition to oral and enteral nutrition (EN) can be difficult also due to abnormal gastrointestinal motility. The gut hormone ghrelin is increased in states of negati

Externí odkaz: https://doaj.org/article/3084db30791b44a481ef4d22572d4282

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Akademický článek

Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states

Autor: Behiye Özcan, Pieter J. M. Leenen, Patric J. D. Delhanty, Lucy Y. Baldéon-Rojas, Sebastian J. Neggers, Aart Jan van der Lely

Publikováno v: Diabetology & Metabolic Syndrome, Vol 9, Iss 1, Pp 1-9 (2017)

Abstract Background Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous studies suggest that

Externí odkaz: https://doaj.org/article/4ca930cbad894b8daf33962ba2de46f8

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Ghrelin deficiency sex-dependently affects food intake, locomotor activity, and adipose and hepatic gene expression in a binge-eating mouse model

Autor: Karina Prins, Martin Huisman, Anke McLuskey, Rosinda Mies, Bas Karels, Patric J. D. Delhanty, Jenny A. Visser

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism, 322(6), E494-E507. American Physiological Society

Binge-eating disorder is the most prevalent eating disorder diagnosed, affecting three times more women than men. Ghrelin stimulates appetite and reward signaling, and loss of its receptor reduces binge-eating behavior in male mice. Here, we examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303af3b71b1f9f605d5522041076bc12
https://doi.org/10.1152/ajpendo.00432.2021

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Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant

Autor: Eline S van der Valk, Lotte Kleinendorst, Patric J D Delhanty, Bibian van der Voorn, Jenny A Visser, M M van Haelst, Laura C G de Graaff, Martin Huisman, Anne White, Shosuke Ito, Kazumasa Wakamatsu, Yolanda B de Rijke, Erica L T van den Akker, Anand M Iyer, Elisabeth F C van Rossum

Publikováno v: Van Der Valk, E S, Kleinendorst, L, Delhanty, P J D, Van Der Voorn, B, Visser, J A, Van Haelst, M M, De Graaff, L C G, Huisman, M, White, A, Ito, S, Wakamatsu, K, De Rijke, Y B, Van Den Akker, E L T, Iyer, A M & Van Rossum, E F C 2022, ' Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant ', The Journal of Clinical Endocrinology & Metabolism . https://doi.org/10.1210/clinem/dgac342
Journal of clinical endocrinology and metabolism, 107(9), e3699-e3704. The Endocrine Society
The Journal of clinical endocrinology and metabolism, 107(9), e3699-e3704. The Endocrine Society
The Journal of clinical endocrinology and metabolism, 107(9), e3699-e3704. Endocrine Society
van der Valk, E S, Kleinendorst, L, Delhanty, P J D, van der Voorn, B, Visser, J A, van Haelst, M M, de Graaff, L C G, Huisman, M, White, A, Ito, S, Wakamatsu, K, de Rijke, Y B, van den Akker, E L T, Iyer, A M & van Rossum, E F C 2022, ' Obesity and Hyperphagia With Increased Defective ACTH : A Novel POMC Variant ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 9, pp. e3699-e3704 . https://doi.org/10.1210/clinem/dgac342

Objective Patients with pro-opiomelanocortin (POMC) defects generally present with early-onset obesity, hyperphagia, hypopigmentation and adrenocorticotropin (ACTH) deficiency. Rodent models suggest that adequate cleavage of ACTH to α-melanocortin�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076e0e026727c100e5af47584bdf85c0
https://pure.manchester.ac.uk/ws/files/223877546/20220511_revised_manuscript_POMC_cases.docx

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MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin

Autor: Aart Jan van der Lely, Patric J. D. Delhanty, Sebastian J C M M Neggers

Publikováno v: European Journal of Endocrinology. 167:601-608

Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been considered an inert degradation product of acyl ghrelin (AG). Recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a767f74b573be55d63d98154b69fdf99
https://doi.org/10.1530/eje-12-0456

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