Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patric Glynn"'
Autor:
Amy C. Sturm, Crystal F. Kline, Patric Glynn, Benjamin L. Johnson, Jerry Curran, Ahmet Kilic, Robert S. D. Higgins, Philip F. Binkley, Paul M. L. Janssen, Raul Weiss, Subha V. Raman, Steven J. Fowler, Silvia G. Priori, Thomas J. Hund, Cynthia A. Carnes, Peter J. Mohler
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 4, Iss 5, Pp n/a-n/a (2015)
Background Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome sequencing with well‐established clinical, translational, and basic science platforms could provi
Externí odkaz:
https://doaj.org/article/e4f120ba886c443b8dc73f4dcedbceac
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89049 (2014)
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium. Sinoatrial node dysfunction, characterized by slow and/or asynchronous pace
Externí odkaz:
https://doaj.org/article/67f83efc4d16428e88c745cf7d40bdd2
Autor:
Ingrid M. Bonilla, Sanjay Kumar, Stephen Baine, Vadim V. Fedorov, Patric Glynn, Kent Mowrey, Raul Weiss, Nam Y. Lee, Victor P. Long, Sandor Gyorke, Karsten E. Schober, Cynthia A. Carnes, Thomas J. Hund, Peter J. Mohler
Publikováno v:
Life Sci
AIMS: Bradycardia contributes to tachy-brady arrhythmias or sinus arrest during heart failure (HF). Sinoatrial node (SAN) adenosine A1 receptors (ADO A1Rs) are upregulated in HF, and adenosine is known to exert negative chronotropic effects on the SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369518a6ac6f3914809b2e293f2212b8
https://pubmed.ncbi.nlm.nih.gov/31751583
https://pubmed.ncbi.nlm.nih.gov/31751583
Publikováno v:
Life Sciences. 111:1-5
Mathematical models are invaluable tools for understanding the relationships between components of a complex system. In the biological context, mathematical models help us understand the complex web of interrelations between various components (DNA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaae751db2ba3e2a2fa245da4ec12c2
https://doi.org/10.1016/j.lfs.2014.07.005
https://doi.org/10.1016/j.lfs.2014.07.005
Autor:
Pedro Vargas-Pinto, Ingrid M. Bonilla, Adriana Pedraza-Toscano, Yoshinori Nishijima, Patric Glynn, Hsiang-Ting Ho, Robert L. Hamlin, Raul Weiss, Victor P. Long, Andriy E. Belevych, Thomas J. Hund, Sandor Gyorke, Cynthia A. Carnes, Troy E. Rhodes, Mahmoud Houmsse
Publikováno v:
Journal of Cardiovascular Electrophysiology. 25:299-306
Ibandronate-Induced Proarrhythmia Introduction Bisphosphonates, including ibandronate, are used in the prevention and treatment of osteoporosis. Methods and Results We report a case of suspected ibandronate-associated arrhythmia, following a single d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a61eb11dc89a30d3b82d2c1759717e3
https://doi.org/10.1111/jce.12327
https://doi.org/10.1111/jce.12327
Autor:
Xiaoqun Guan, Di Lang, Jinying Yang, Paari Dominic Swaminathan, Baoli Yang, William Kutschke, Lars S. Maier, Adam G. Rokita, Min Luo, Samuel Sossalla, Igor R. Efimov, Thomas J. Hund, Zhan Gao, Patric Glynn, Robert M. Weiss, Elizabeth D. Luczak, Mark E. Anderson
Publikováno v:
Journal of Clinical Investigation. 123:1262-1274
Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction, but the mechanisms underlying increased mortality are unknown. Mice with streptozotocin-induced diabetes developed profound heart rate slowing and doubled mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b30cf1a5b005ce901f74d331625ac5
https://doi.org/10.1172/jci65268
https://doi.org/10.1172/jci65268
Autor:
Patric Glynn, Peter J. Mohler, Philip F. Binkley, Nicholas D. Leymaster, Ryan E. Pavlovicz, Roseanne M. Wolf, Colleen C. Mitchell, Mark E. Anderson, Lan Qian, Patrick Wright, Jerry Curran, Olha M. Koval, Chenglong Li, Wen Dun, Penelope A. Boyden, Thomas J. Hund, Natalia Cardona, Jedidiah S. Snyder
Publikováno v:
Circulation. 126:2084-2094
Background— Human gene variants affecting ion channel biophysical activity and/or membrane localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism for many human arrhythmia variants remains undefined despite more th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c25609a26d57a33097b544bfee86a29
https://doi.org/10.1161/circulationaha.112.105320
https://doi.org/10.1161/circulationaha.112.105320
Autor:
Xiangqiong Wu, Przemysław B. Radwański, Sean C. Little, Sandor Gyorke, Lan Qian, Patrick Wright, Thomas J. Hund, Peter J. Mohler, Hassan Hussein Musa, Patric Glynn, Sathya D. Unudurthi
Background— Voltage-gated Na + channels (Na v ) are essential for myocyte membrane excitability and cardiac function. Na v current ( I Na ) is a large-amplitude, short-duration spike generated by rapid channel activation followed immediately by ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cca60e77708369be508a1db610f977
https://europepmc.org/articles/PMC4543581/
https://europepmc.org/articles/PMC4543581/
Use of Whole Exome Sequencing for the Identification of I to ‐Based Arrhythmia Mechanism and Therapy
Autor:
Robert S.D. Higgins, Benjamin L. Johnson, Amy C. Sturm, Ahmet Kilic, Crystal F. Kline, Cynthia A. Carnes, Paul M.L. Janssen, Steven J. Fowler, Silvia G. Priori, Patric Glynn, Peter J. Mohler, Raul Weiss, Thomas J. Hund, Philip F. Binkley, Subha V. Raman, Jerry Curran
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome sequencing with well‐established clinical, translational, and basic science platforms could provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589b4b3dba3346edcef5bd270c3e1c44
https://doi.org/10.1161/jaha.114.001762
https://doi.org/10.1161/jaha.114.001762
Autor:
Nicholas D. Leymaster, Birce Onal, Philip F. Binkley, Jedidiah S. Snyder, Celia Camardo, Thomas J. Hund, Patrick J. Wright, Patric Glynn, Sathya D. Unudurthi, Mark E. Anderson, Jerry Curran, Peter J. Mohler, Olha M. Koval, Xiangqiong Wu
Aims Cardiac function depends on the highly regulated and co-ordinate activity of a large ensemble of potassium channels that control myocyte repolarization. While voltage-gated K+ channels have been well characterized in the heart, much less is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8489db6b674aea60b4ae5c3467ffc15
https://europepmc.org/articles/PMC3958619/
https://europepmc.org/articles/PMC3958619/