Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Patrícia Sammarco-Rosa"'
Autor:
Plinio Marcos Freire dos Santos, Chyntia Carolina Díaz Acosta, Thabatta Leal Silveira Andrezo Rosa, Michelle Harumi Ishiba, André Alves Dias, Antonio Marcos Rodrigues Pereira, Luísa Domingos Gutierres, Melissa Pontes Pereira, Matheus da Silva Rocha, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, José Roberto Meyer-Fernandes, Fabricio da Mota Ramalho Costa, Maria Angela M. Marques, John T. Belisle, Roberta Olmo Pinheiro, Luciana Silva Rodrigues, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae, which can lead to a disabling neurodegenerative condition. M. leprae preferentially infects skin macrophages and Schwann cells–glial cells of the peripheral nervous s
Externí odkaz:
https://doaj.org/article/f7ff13b38ef44228826448b683d0162b
Autor:
Natália Aparecida de Paula, Marcel Nani Leite, Daniele Ferreira de Faria Bertoluci, Cleverson Teixeira Soares, Patrícia Sammarco Rosa, Marco Andrey Cipriani Frade
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 9, Iss 6, p 135 (2024)
The in vitro cultivation of M. leprae has not been possible since it was described as causing leprosy, and the limitation of animal models for clinical aspects makes studies on leprosy and bacteria–human host interaction a challenge. Our aim was to
Externí odkaz:
https://doaj.org/article/43b866f4c75c4e1096a3c942aa4710e7
Autor:
Adriana Sierra Assencio Almeida Barbosa, Thayna Sosolote Lima, Beatriz Gomes Carreira Sartori, Suzana Madeira Diório, Sônia Maria Usó Ruiz Silva, Vania Nieto Brito-de-Souza, Maria Renata Sales Nogueira, Patrícia Sammarco Rosa, Sílvia Cristina Barboza Pedrini, Fátima Regina Vilani-Moreno
Publikováno v:
Hansenologia Internationalis, Vol 49 (2024)
Introdução: a hanseníase é uma doença in fecciosa crônica causada pelo Mycobacterium leprae (M. leprae), um parasita intracelular obrigatório. Assim, a resistência do hospedeiro a esse patógeno depende da imunidade celular. O uso de modelos
Externí odkaz:
https://doaj.org/article/0fbe063ceb9044ad8830594164233ad1
Autor:
Rafael Saraiva de Andrade Rodrigues, Eduardo Ferreira José Heise, Luis Felipe Hartmann, Guilherme Eduardo Rocha, Marcia Olandoski, Mariane Martins de Araújo Stefani, Ana Carla Pereira Latini, Cleverson Teixeira Soares, Andrea Belone, Patrícia Sammarco Rosa, Maria Araci de Andrade Pontes, Heitor de Sá Gonçalves, Rossilene Cruz, Maria Lúcia Fernandes Penna, Deborah Ribeiro Carvalho, Vinicius Medeiros Fava, Samira Bührer-Sékula, Gerson Oliveira Penna, Claudia Maria Cabral Moro, Julio Cesar Nievola, Marcelo Távora Mira
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionLeprosy reactions (LR) are severe episodes of intense activation of the host inflammatory response of uncertain etiology, today the leading cause of permanent nerve damage in leprosy patients. Several genetic and non-genetic risk factors
Externí odkaz:
https://doaj.org/article/b26ff41f1e204a50b26f0dc2d27de53e
Autor:
Divya Khanna, Gilles de Wildt, Luiz Antonio Miranda de Souza Duarte Filho, Mitali Bajaj, Jo Freda Lai, Esme Gardiner, Andrea Maia Fernandes de Araújo Fonseca, Antje Lindenmeyer, Patrícia Sammarco Rosa
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-19 (2021)
Abstract Background Brazil has a high leprosy burden and poor treatment outcomes (TOs), manifesting in high relapse rates. Pernambuco, an impoverished Brazilian state suffering notable geographical health inequalities, has ‘hyperendemic’ leprosy.
Externí odkaz:
https://doaj.org/article/2f78692eb7bf4c26a0b253609a5104d3
Autor:
Beatriz Junqueira de Souza, Mayara Abud Mendes, Gilberto Marcelo Sperandio da Silva, Patrícia Sammarco-Rosa, Milton Ozorio de Moraes, Marcia Rodrigues Jardim, Euzenir Nunes Sarno, Roberto Olmo Pinheiro, Bruno Siqueira Mietto
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Peripheral neuropathy is the main cause of physical disability in leprosy patients. Importantly, the extension and pattern of peripheral damage has been linked to how the host cell will respond against Mycobacterium leprae (M. leprae) infection, in p
Externí odkaz:
https://doaj.org/article/f9397b5d0cc94770bf5e5027431564dd
Autor:
André Alves Dias, Carlos Adriano de Matos e Silva, Camila Oliveira da Silva, Natasha Ribeiro Cardoso Linhares, João Pedro Sousa Santos, Aislan de Carvalho Vivarini, Maria Ângela de Mello Marques, Patrícia Sammarco Rosa, Ulisses Gazos Lopes, Márcia Berrêdo-Pinho, Maria Cristina Vidal Pessolani
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The respiratory tract is considered the main port of entry of Mycobacterium leprae, the causative agent of leprosy. However, the great majority of individuals exposed to the leprosy bacillus will never manifest the disease due to their capacity to de
Externí odkaz:
https://doaj.org/article/99a1b08cd85a430aa395dbf26bd9b92d
Autor:
Franciely Gomes Gonçalves, Andréa de Faria Fernandes Belone, Patrícia Sammarco Rosa, Gabriel Zorello Laporta
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background The multidrug therapy (MDT) for leprosy treatment adopted by Brazil in the 1990s was important for reducing leprosy in the country; however, recurrent cases remained problematic. Mechanisms involved in leprosy recurrence are heter
Externí odkaz:
https://doaj.org/article/4fc14aaf52024b26968b9cf4b85f3cce
Autor:
Patrícia Sammarco Rosa
Publikováno v:
Hansenologia Internationalis, Vol 43 (2020)
Externí odkaz:
https://doaj.org/article/9a248af01a0f4e1f8abacd26ca51fae8
Autor:
Maria Renata Sales Nogueira, Nádia Ghinelli Amôr, Letícia Baccaro Michellin, Milton Cury Filho, Patrícia Sammarco Rosa, Ana Carla Pereira Latini, Luciana Silva Rodrigues, Robertha Mariana Rodrigues Lemes, Flavio Alves Lara, Maria Cristina Vidal Pessolani
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 115 (2020)
BACKGROUND Although Mycobacterium leprae (ML) is well characterised as the causative agent of leprosy, the pathophysiological mechanisms underlying peripheral nerve damage still need further understanding. In vitro and in vivo studies have yielded in
Externí odkaz:
https://doaj.org/article/0c4be3b7e2ee41c7b60ae5a13ae0e92d