Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Patrícia S. M. Amado"'
Publikováno v:
Toxins, Vol 16, Iss 4, p 200 (2024)
Okadaic acid (OA) is one of the most potent marine biotoxins, causing diarrheal shellfish poisoning (DSP). The proliferation of microalgae that produce OA and its analogues is frequent, threatening human health and socioeconomic development. Several
Externí odkaz:
https://doaj.org/article/e738a5316dc442cb9327a8374e0ec233
Publikováno v:
Foods, Vol 12, Iss 4, p 768 (2023)
The accumulation of marine biotoxins in shellfish and their consumption causes serious food safety problems, threatening human health and compromising the availability of protein-based food. It is thus urgent to develop methodologies for the detoxifi
Externí odkaz:
https://doaj.org/article/f5cd8dc9cb7641de9e80a888ee5c3202
Autor:
Patrícia S. M. Amado, Inês C. C. Costa, José A. Paixão, Ricardo F. Mendes, Sofia Cortes, Maria L. S. Cristiano
Publikováno v:
Molecules, Vol 27, Iss 17, p 5401 (2022)
Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activi
Externí odkaz:
https://doaj.org/article/cf90b761f92443a19cc59940ce9b3181
Autor:
Andreia Mendes, Ana Armada, Lília I. L. Cabral, Patrícia S. M. Amado, Lenea Campino, Maria L. S. Cristiano, Sofia Cortes
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 446 (2022)
Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This s
Externí odkaz:
https://doaj.org/article/0cf6f7312c484de493ffe65053e35def
Autor:
Joana F. Leal, Bruno Guerreiro, Patrícia S. M. Amado, André L. Fernandes, Luísa Barreira, José A. Paixão, Maria L. S. Cristiano
Publikováno v:
Molecules, Vol 26, Iss 6, p 1501 (2021)
Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal ar
Externí odkaz:
https://doaj.org/article/a7c0d84a6bde4053b786aeaa38417a6e
Autor:
Lília I. L. Cabral, Sébastien Pomel, Sandrine Cojean, Patrícia S. M. Amado, Philippe M. Loiseau, Maria L. S. Cristiano
Publikováno v:
Molecules, Vol 25, Iss 3, p 465 (2020)
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm. The most
Externí odkaz:
https://doaj.org/article/9cd41be9f44c4a038687e34f98a6e013
Publikováno v:
ACS Omega. 7:40659-40681
D e cap renylp ho sp ho ryl-beta-D-rib os e 2 '-epimerase (DprE1) is a critical flavoenzyme in Mycobacterium tuberculosis, catalyzing a vital step in the production of lipoarabinomannan and arabinogalactan, both of which are essential for cell wall b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081968ab43b989232335a2811391fde2
https://doi.org/10.1021/acsomega.2c05307
https://doi.org/10.1021/acsomega.2c05307
Plasmodium falciparum artemisinin-resistance boosted the quest for novel plasmodial "fast killers," uncovering antimalarial candidates OZ439 and E209, whose peroxide precursors are 1,2,4-trioxolane (1) and 1,2,4,5-tetraoxane (2), differing solely in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a952441bb2a829bb8270e254897698
https://hdl.handle.net/10400.1/18662
https://hdl.handle.net/10400.1/18662
Autor:
Patrícia S M Amado, José A. Paixão, Luísa Barreira, Bruno J. Guerreiro, Maria Lurdes Santos Cristiano, André L. Fernandes, Joana F Leal
Publikováno v:
Molecules
Molecules, Vol 26, Iss 1501, p 1501 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules, Vol 26, Iss 1501, p 1501 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37355bda0a81af7d98119b4dc3a633e3
Autor:
Paul M. O'Neill, Jaime A. S. Coelho, Luís M.T. Frija, Patrícia S M Amado, Maria Lurdes Santos Cristiano
Publikováno v:
The Journal of Organic Chemistry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
A novel protocol for the preparation of nonsymmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes, promoted by the heterogeneous silica sulfuric acid (SSA) catalyst, is reported. Different ketones react under mild conditions with gemdihydroperoxides or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c89434a86aa53e56587733af98b9ec2
https://hdl.handle.net/10400.1/17165
https://hdl.handle.net/10400.1/17165