Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Patrícia Bernardino da Silva"'
Autor:
Maria de Nazaré C Soeiro, Andréia P Dantas, Anissa Daliry, Cristiane F da Silva, Denise GJ Batista, Elen M de Souza, Gabriel M Oliveira, Kelly Salomão, Marcos Meuser Batista, Michelle GO Pacheco, Patrícia Bernardino da Silva, Ricardo M Santa-Rita, Rubem FS Menna Barreto, David W Boykin, Solange Lisboa de Castro
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 104, Pp 301-310 (2009)
Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health pr
Externí odkaz:
https://doaj.org/article/d78b948d399648f8bda9589cd3d419d2
Autor:
Guy Caljon, Louis Maes, Geert Jan Sterk, Maria de Nazaré Correia Soeiro, Raiza Brandão Peres, Titilola D. Kalejaiye, Julianna Siciliano de Araújo, Rob Leurs, Patrícia Bernardino da Silva, Marcos Meuser Batista, Harry P. de Koning
Publikováno v:
De Araújo, J S, Peres, R B, Da Silva, P B, Batista, M M, Sterk, G J, Maes, L, Caljon, G, Leurs, R, De Koning, H P, Kalejaiye, T D & De Nazaré Correia Soeiro, M 2021, ' Tetrahydrophthalazinone inhibitor of phosphodiesterase with in vitro activity against intracellular trypanosomatids ', Antimicrobial agents and chemotherapy, vol. 65, no. 3, e00960-20, pp. 1-5 . https://doi.org/10.1128/AAC.00960-20
Antimicrob Agents Chemother
Antimicrobial agents and chemotherapy, 65(3):e00960-20, 1-5. American Society for Microbiology
Antimicrobial agents and chemotherapy
Antimicrob Agents Chemother
Antimicrobial agents and chemotherapy, 65(3):e00960-20, 1-5. American Society for Microbiology
Antimicrobial agents and chemotherapy
The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation, and ultrastructural approaches against Trypanosoma cruzi . NPD-008 displayed activity against different forms and strain
Autor:
Lavínia de Carvalho Brito, Patrícia Bernardino da Silva, Ludmila Ferreira de Almeida Fiuza, Marcos Meuser Batista, Flávia da C. Camillo, André M. Marques, Raiza Brandão Peres, Maria Raquel Figueiredo, Maria de Nazaré Correia Soeiro
Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5676, p 5676 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5676, p 5676 (2021)
Chagas disease (CD) affects more than 6 million people worldwide. The available treatment is far from ideal, creating a demand for new alternative therapies. Botanical diversity provides a wide range of novel potential therapeutic scaffolds. Presentl
Autor:
Vitor F. Ferreira, Kelly Salomão, Juliana M. C. Barbosa, Débora Omena Futuro, Patrícia Bernardino da Silva, Tatiana G. Melo, Caroline D. Nicoletti
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0246811 (2021)
PLoS ONE, Vol 16, Iss 3, p e0246811 (2021)
The treatment of Chagas disease (CD), a neglected parasitic condition caused by Trypanosoma cruzi, is still based on only two drugs, nifurtimox (Nif) and benznidazole (Bz), both of which have limited efficacy in the late chronic phase and induce seve
Autor:
Geert Jan Sterk, Titilola D. Kalejaiye, Cristiane França da Silva, Julianna Siciliano de Araújo, Maarten Sijm, Rob Leurs, Ludmila Ferreira de Almeida Fiuza, Harry P. de Koning, Cristina Fonseca-Berzal, Denise da Gama Jaen Batista, Louis Maes, Maria de Nazaré Correia Soeiro, A. S. G. Nefertiti, Marcos Meuser Batista, Patrícia Bernardino da Silva
Publikováno v:
Antimicrobial agents and chemotherapy, 64(9):e00414-20, 1-11. American Society for Microbiology
Antimicrobial agents and chemotherapy
de Araújo, J S, França da Silva, C, Batista, D D G J, Nefertiti, A, Fiuza, L F D A, Fonseca-Berzal, C R, Bernardino da Silva, P, Batista, M M, Sijm, M, Kalejaiye, T D, de Koning, H P, Maes, L, Sterk, G J, Leurs, R & Soeiro, M D N C 2020, ' Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi ', Antimicrobial agents and chemotherapy, vol. 64, no. 9, e00414-20, pp. 1-11 . https://doi.org/10.1128/AAC.00414-20
Antimicrob Agents Chemother
Antimicrobial agents and chemotherapy
de Araújo, J S, França da Silva, C, Batista, D D G J, Nefertiti, A, Fiuza, L F D A, Fonseca-Berzal, C R, Bernardino da Silva, P, Batista, M M, Sijm, M, Kalejaiye, T D, de Koning, H P, Maes, L, Sterk, G J, Leurs, R & Soeiro, M D N C 2020, ' Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi ', Antimicrobial agents and chemotherapy, vol. 64, no. 9, e00414-20, pp. 1-11 . https://doi.org/10.1128/AAC.00414-20
Antimicrob Agents Chemother
Pyrazolones are heterocyclic compounds with interesting biological properties. Some derivatives inhibit phosphodiesterases (PDEs) and thereby increase the cellular concentration of cyclic AMP (cAMP), which plays a vital role in the control of metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfe21cadb9de1ab732be994c539a37c
https://research.vu.nl/en/publications/60532e52-ce8d-4c5f-8df6-e8d9f01083b2
https://research.vu.nl/en/publications/60532e52-ce8d-4c5f-8df6-e8d9f01083b2
Autor:
José Daniel Figueroa Villar, Lucas Villas Bôas Hoelz, Maria de Nazaré Correia Soeiro, Aline Nefertiti Silva da Gama, Fábio de Vasconcellos Fontes, D. G. J. Batista, Patrícia Bernardino da Silva, Cristiane França da Silva, Nubia Boechat, Débora Inácio Leite, Maria da Conceição Avelino Dias Bianco, Mônica M. Bastos, Raiza Brandão Peres, Andressa Paula de Oliveira
Publikováno v:
Chemical Biology & Drug Design. 92:1670-1682
Chagas disease has spread throughout the world mainly because of the migration of infected individuals. In Brazil, only benznidazole (Bnz) is used; however, it is toxic and not active in the chronic phase, and cases of resistance are described. This
Autor:
Jane C. Munday, An Matheeussen, Camila Cardoso-Santos, Titilola D. Kalejaiye, Marcos Meuser Batista, Rob Leurs, Iwan J. P. de Esch, Harry P. de Koning, Maria de Nazaré Correia Soeiro, Patrícia Bernardino da Silva, Irene G. Salado, Louis Maes, Erik de Heuvel, Raiza Brandão Peres, Geert Jan Sterk, Koen Augustyns, Julianna Siciliano de Araújo
Publikováno v:
Journal of antimicrobial chemotherapy, 75(4), 958-967. Oxford University Press
The journal of antimicrobial chemotherapy
De Araújo, J S, da Silva, P B, Batista, M M, Peres, R B, Cardoso-Santos, C, Kalejaiye, T D, Munday, J C, De Heuvel, E, Sterk, G J, Augustyns, K, Salado, I G, Matheeussen, A, De Esch, I, De Koning, H P, Leurs, R, Maes, L & Soeiro, M D N C 2020, ' Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi ', Journal of antimicrobial chemotherapy, vol. 75, no. 4, pp. 958-967 . https://doi.org/10.1093/jac/dkz516
The journal of antimicrobial chemotherapy
De Araújo, J S, da Silva, P B, Batista, M M, Peres, R B, Cardoso-Santos, C, Kalejaiye, T D, Munday, J C, De Heuvel, E, Sterk, G J, Augustyns, K, Salado, I G, Matheeussen, A, De Esch, I, De Koning, H P, Leurs, R, Maes, L & Soeiro, M D N C 2020, ' Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi ', Journal of antimicrobial chemotherapy, vol. 75, no. 4, pp. 958-967 . https://doi.org/10.1093/jac/dkz516
Background Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, needs urgent alternative therapeutic options as the treatments currently available display severe limitations, mainly related to efficacy and toxicity. Objectives As ph
Autor:
José Cumella, Juan José Nogal-Ruiz, Alexandra Ibáñez-Escribano, Vicente J. Arán, Felipe Reviriego, Nadine Jagerovic, Cristina Fonseca-Berzal, Patrícia Bernardino da Silva, Maria de Nazaré Correia Soeiro, Alicia Gómez-Barrio, José Antonio Escario, Paula Morales
Publikováno v:
European Journal of Medicinal Chemistry. 115:295-310
Two series of new 5-nitroindazole derivatives, 1-substituted 2-benzylindazolin-3-ones ( 6 – 29 , series A ) and 3-alkoxy-2-benzyl-2 H -indazoles ( 30 – 37 , series B ), containing differently functionalized chains at position 1 and 3, respectivel
Autor:
M. M. Batista, Claudia Alessandra Fortes Aiub, Patrícia Bernardino da Silva, Israel Felzenszwalb, Carlos Fernando Araujo-Lima, Maria de Nazaré Correia Soeiro, Raiza Brandão Peres
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Statins are inhibitors of cholesterol synthesis, but other biological properties, such as antimicrobial effects, have also been assigned to them, leading to their designation as pleiotropic agents. Our goal was to investigate the activity and selecti
Autor:
Olivia Corcoran, Marcos Meuser Batista, Asma Inam Ullah, Raiza Brandão Peres, Maria de Nazaré Correia Soeiro, Patrícia Bernardino da Silva, Ludmila Ferreira de Almeida Fiuza, Tummala Rama Krishna Reddy
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(11)
Chagas disease is a neglected pathology responsible for about 12,000 deaths every year across Latin America. Although six million people are infected by the Trypanosoma cruzi, current therapeutic options are limited, highlighting the need for new dru