CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion

Autor: Sónia Norberto, Heloisa Balan Assalin, Dioze Guadagnini, Natália Tobar, Patrícia Aline Boer, Min-Cheol Kang, Mario Jose Abdalla Saad, Young-Bum Kim, Patricia Oliveira Prada

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionCdc2-like kinase (CLK2) is a member of CLK kinases expressed in hypothalamic neurons and is activated in response to refeeding, leptin, or insulin. Diet-induced obesity and leptin receptor-deficient db/db mice lack CLK2 signal in the hypo

Externí odkaz: https://doaj.org/article/14a28ecf3ddc4b9b980ecebce706f71c

Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis

Autor: Letícia de Barros Sene, Gabriela Leme Lamana, Andre Schwambach Vieira, Wellerson Rodrigo Scarano, José Antônio Rocha Gontijo, Patrícia Aline Boer

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BackgroundThe kidney ontogenesis is the most structurally affected by gestational protein restriction, reducing 28% of their functional units. The reduced nephron number is predictive of hypertension and cardiovascular dysfunctions that are generally

Externí odkaz: https://doaj.org/article/7d48b163fb8c45fe8181c97fc68b341a

Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus.

Autor: Letícia de Barros Sene, Wellerson Rodrigo Scarano, Adriana Zapparoli, José Antônio Rocha Gontijo, Patrícia Aline Boer

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0246289 (2021)

BackgroundHere, we have demonstrated that gestational low-protein (LP) intake offspring present lower birth weight, reduced nephron numbers, renal salt excretion, arterial hypertension, and renal failure development compared to regular protein (NP) i

Externí odkaz: https://doaj.org/article/6c776e18cc424597ae84d67d606f979c

miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring.

Autor: Heloisa Balan Assalin, José Antonio Rocha Gontijo, Patrícia Aline Boer

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0210454 (2019)

Gestational protein restriction was associated with low birth weight, hypertension and higher prevalence of cardiac disorders in adults. Several mechanisms, including epigenetics, could be related with the cardiovascular phenotype on protein-restrict

Externí odkaz: https://doaj.org/article/4052067004c34ad4949dc317cac96f86

Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis

Autor: José Antonio Rocha Gontijo, Wellerson Rodrigo Scarano, Gabriela Leme Lamana, André Schwambach Vieira, Letícia de Barros Sene, Patrícia Aline Boer

Publikováno v: Frontiers in Physiology, Vol 12 (2021)
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Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Frontiers in Physiology

Made available in DSpace on 2022-05-01T06:02:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-22 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: The kidney ontogenesis is the most structurally affected by ges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8590918f19792ffe12524d8222677efd
https://www.frontiersin.org/articles/10.3389/fphys.2021.648056/full