Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Patient-derived xenografts (PDX)"'
Autor:
Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones McCall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E. Crawford, Steven M. Lipkin, Xiao‐Fan Wang, Hans Clevers, David Hsu, Xiling Shen
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear
Externí odkaz:
https://doaj.org/article/1bb7ddf32e6044c991fd4618eff54a98
Autor:
Veronica Giusti, Giacomo Miserocchi, Giulia Sbanchi, Micaela Pannella, Claudia Maria Hattinger, Marilena Cesari, Leonardo Fantoni, Ania Naila Guerrieri, Chiara Bellotti, Alessandro De Vita, Chiara Spadazzi, Davide Maria Donati, Monica Torsello, Enrico Lucarelli, Toni Ibrahim, Laura Mercatali
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1921 (2024)
Musculoskeletal sarcomas pose major challenges to researchers and clinicians due to their rarity and heterogeneity. Xenografting human cells or tumor fragments in rodents is a mainstay for the generation of cancer models and for the preclinical trial
Externí odkaz:
https://doaj.org/article/b62b69d1957b47d4ae7db370d746fddf
Autor:
Laura Pohl, Jana Friedhoff, Christina Jurcic, Miriam Teroerde, Isabella Schindler, Konstantina Strepi, Felix Schneider, Adam Kaczorowski, Markus Hohenfellner, Anette Duensing, Stefan Duensing
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Renal cell carcinoma (RCC) is among the most lethal urological malignancies once metastatic. The introduction of immune checkpoint inhibitors has revolutionized the therapeutic landscape of metastatic RCC, nevertheless, a significant proportion of pa
Externí odkaz:
https://doaj.org/article/8d681f0e13ae455892f3aa44b6f0c5c1
Akademický článek
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Autor:
Xingxiang Pu, Ran Zhang, Li Wang, Yungchang Chen, Yi Xu, Apar Pataer, Ismail M. Meraz, Xiaoshan Zhang, Shuhong Wu, Lin Wu, Dan Su, Weimin Mao, John V. Heymach, Jack A. Roth, Stephen G. Swisher, Bingliang Fang
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background Because patient-derived xenografts (PDXs) are grown in immunodeficient mouse strains, PDXs are regarded as lacking an immune microenvironment. However, whether patients’ immune cells co-exist in PDXs remains uncharacterized. Met
Externí odkaz:
https://doaj.org/article/6894e6771c634171aa7604d1ac710e1d
Autor:
Knier, Natasha
Publikováno v:
Electronic Thesis and Dissertation Repository
Introduction: Breast cancer remains a leading cause of mortality among women due to the propensity of breast tumours to spread and metastasize to distant sites, including the brain. Early detection of metastatic disease has been challenging, and typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1548::2530ff38b2c1ea0573dfbddf2fe2bbc2
https://ir.lib.uwo.ca/etd/9238
https://ir.lib.uwo.ca/etd/9238
Akademický článek
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Akademický článek
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Autor:
Prachi Bajpai, Nilam Sanjib Banerjee, Dianne W. Moore, Hyung-Gyoon Kim, Farrukh Afaq, Carlo M. Contreras, Martin J. Heslin, Vishnu B. Reddy, Shajan Peter, Sooryanarayana Varambally, Sameer Al Diffalha, Upender Manne
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14392
Reliable preclinical models are needed for screening new cancer drugs. Thus, we developed an improved 3D tumor organoid model termed “organoid raft cultures” (ORCs). Development of ORCs involved culturing tumors ex vivo on collagen beds (boats) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2796b7977be631b3b7de6d7f78796d8
Autor:
Christian T. Stackhouse, James R. Rowland, Rachael S. Shevin, Raj Singh, G. Yancey Gillespie, Christopher D. Willey
Publikováno v:
Cells, Vol 8, Iss 7, p 702 (2019)
Accurate patient-derived models of cancer are needed for profiling the disease and for testing therapeutics. These models must not only be accurate, but also suitable for high-throughput screening and analysis. Here we compare two derivative cancer m
Externí odkaz:
https://doaj.org/article/0e0abafa8da94371916b3afe24a8c172