Zobrazeno 1 - 10
of 855
pro vyhledávání: '"Patient-derived organoids"'
Autor:
Elham Aida Farshadi, Wenya Wang, Farzana Mohammad, Elise van der Oost, Michail Doukas, Casper H. J. van Eijck, Harmen J. G. van de Werken, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents challenges in detecting somatic mutations due to its complex cellular composition. This study investigated the utility of patient-derived organoids (PDOs) to overcome these obstacles and enhan
Externí odkaz:
https://doaj.org/article/77ac9a8ef4ef4a1b84739b3ddce172bb
Autor:
Lin-Yu Chen, Yu-Ting Chou, Phui-Ly Liew, Ling-Hui Chu, Kuo-Chang Wen, Shiou-Fu Lin, Yu-Chun Weng, Hui-Chen Wang, Po-Hsuan Su, Hung-Cheng Lai
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only 60–70% in advanced stages, and even lower as a second-line treatment. Despite guideline recommendations,
Externí odkaz:
https://doaj.org/article/ad9976421da742c6a2aa45c571630064
Autor:
Katarína Benčurová, Loan Tran, Joachim Friske, Kajetana Bevc, Thomas H. Helbich, Marcus Hacker, Michael Bergmann, Markus Zeitlinger, Alexander Haug, Markus Mitterhauser, Gerda Egger, Theresa Balber
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background Patient-derived tumour organoids (PDOs) are highly advanced in vitro models for disease modelling, yet they lack vascularisation. To overcome this shortcoming, organoids can be inoculated onto the chorioallantoic membrane (CAM); t
Externí odkaz:
https://doaj.org/article/48f2547814c0420393b98e3489f9e77f
Autor:
Bernadette Jeremiasse, Ravian L van Ineveld, Veerle Bok, Michiel Kleinnijenhuis, Sam de Blank, Maria Alieva, Hannah R Johnson, Esmée J van Vliet, Amber L Zeeman, Lianne M Wellens, Gerard Llibre-Palomar, Mario Barrera Román, Alessia Di Maggio, Johanna F Dekkers, Sabrina Oliveira, Alexander L Vahrmeijer, Jan J Molenaar, Marc HWA Wijnen, Alida FW van der Steeg, Ellen J Wehrens, Anne C Rios
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1495-1514 (2024)
Abstract Achieving complete tumor resection is challenging and can be improved by real-time fluorescence-guided surgery with molecular-targeted probes. However, pre-clinical identification and validation of probes presents a lengthy process that is t
Externí odkaz:
https://doaj.org/article/59beb6ac34b24791970db0bb11a508eb
Autor:
CHEN Hong, CAO Zhiyun
Publikováno v:
Zhongguo aizheng zazhi, Vol 34, Iss 6, Pp 590-597 (2024)
Pancreatic cancer is a worldwide medical and health problem. Due to its high heterogeneity and malignant phenotype, the 5-year survival rate of pancreatic cancer is only 7.2%, which is a serious threat to human health. The biological mechanism and dr
Externí odkaz:
https://doaj.org/article/5d48e879b50144b2a6439828f4fbc925
Autor:
Serena Mazzucchelli, Lorena Signati, Letizia Messa, Alma Franceschini, Arianna Bonizzi, Lorenzo Castagnoli, Patrizia Gasparini, Clarissa Consolandi, Eleonora Mangano, Paride Pelucchi, Ingrid Cifola, Tania Camboni, Marco Severgnini, Laura Villani, Barbara Tagliaferri, Stephana Carelli, Serenella M. Pupa, Cristina Cereda, Fabio Corsi
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast cancer (BC) to investigate the tumour evolution before and after neoadjuvant chemotherapy
Externí odkaz:
https://doaj.org/article/87a0c667c3c14d669d41b5cdc4ebd64b
Autor:
Iris W.J.M. van Goor, Leon Raymakers, Daan S.H. Andel, Lodewijk A.A. Brosens, Onno Kranenburg, Jeanette H.W. Leusen, Gert J. Meijer, I. Quintus Molenaar, Hjalmar C. van Santvoort, J.H. Wilfred de Vries, Andre J.M. Wopereis, Martijn P.W. Intven, Lois A. Daamen
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 48, Iss , Pp 100829- (2024)
Background: The effectiveness of radiotherapy for pancreatic cancer is debated. Patient-derived organoids (PDOs) already mimicked clinical radiation response in other cancer types, which could be valuable in pancreatic cancer as well. This study aime
Externí odkaz:
https://doaj.org/article/d8a344c2c6f941d3a03e2dacb74c34f8
Autor:
XiaoChang Fang, Lin Shu, TianLiang Chen, XiaoLe Zhao, LiuCui Yang, Tingting Dou, Lijie Yang, Xuanfei Li, Maohui Feng
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Malignant peritoneal mesothelioma (MPM) is an extremely rare and highly invasive tumor. Due to the lack of accurate models that reflect the biological characteristics of primary tumors, studying MPM remains challenging and is asso
Externí odkaz:
https://doaj.org/article/021181a682df48deb1583ed04cb35775
Autor:
Pedro Fonseca, Weiyingqi Cui, Nona Struyf, Le Tong, Ayushi Chaurasiya, Felipe Casagrande, Honglei Zhao, Dinura Fernando, Xinsong Chen, Nicholas P. Tobin, Brinton Seashore-Ludlow, Andreas Lundqvist, Johan Hartman, Anita Göndör, Päivi Östling, Lars Holmgren
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it expands into healthy tissues. The presence of these clu
Externí odkaz:
https://doaj.org/article/33dfb61ce30b4942b583460a044384b6
Autor:
Larissa Ruhe, Sonja Heibl, Manfred Czompo, Johannes Haybaeck, Jürgen Loskutov, Manuela Johanna Regenbrecht, Josef Thaler, Lena Wedeken, Christian René Alexander Regenbrecht
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 490-496 (2024)
Introduction: Controlled randomized trials, molecular analytics, and guideline recommendations have so far been irreplaceable tools to ensure appropriate treatment and decision-making for physicians and patients. Individual patient models are increas
Externí odkaz:
https://doaj.org/article/389f7ad980334d7a930d50912475fae7