Zobrazeno 1 - 10
of 355
pro vyhledávání: '"Patient-Oriented and Epidemiological Research"'
Progression of chronic kidney disease in familial LCAT deficiency: a follow-up of the Italian cohort
Autor:
Tiziano Lucchi, Tiziana Sampietro, Giuliano Boscutti, Fabrizio Veglia, Alice Ossoli, Loreto Gesualdo, Marcello Arca, Laura Calabresi, Laura D'Erasmo, Chiara Pavanello
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1784-1788 (2020)
J Lipid Res
J Lipid Res
Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1504-1511 (2020)
J Lipid Res
J Lipid Res
Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical
Autor:
Hideaki Bujo, Akihito Takei, Hisataka Yamazaki, Jun-ichi Osuga, Shoko Takei, Manabu Takahashi, Masayuki Kuroda, Adriaan G. Holleboom, Shuichi Nagashima, Tetsuji Wakabayashi, Shun Ishibashi, Daisuke Yamamuro, Kenta Okada
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1287-1299 (2020)
J Lipid Res
Journal of lipid research, 61(9), 1287-1299. American Society for Biochemistry and Molecular Biology Inc.
J Lipid Res
Journal of lipid research, 61(9), 1287-1299. American Society for Biochemistry and Molecular Biology Inc.
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in
Autor:
Peter J. Meikle, Patrice Thérond, Alexina Orsoni, Ricardo Tan, Philippe Giral, Paul Robillard, Anh Nguyen, M. John Chapman, Natalie A. Mellett
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (6), pp.911-932. ⟨10.1194/jlr.P119000543⟩
Journal of Lipid Research, Vol 61, Iss 6, Pp 911-932 (2020)
J Lipid Res
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (6), pp.911-932. ⟨10.1194/jlr.P119000543⟩
Journal of Lipid Research, Vol 61, Iss 6, Pp 911-932 (2020)
J Lipid Res
International audience; Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDLsubclasses, and thus potential atherogenicity? What is the effect of statin treatment? Obese hypertrig
Autor:
Phillip E. Melton, Natalie A. Mellett, Peter J. Meikle, Gerald F. Watts, Nina S. McCarthy, Gemma Cadby, Marie-Pierre Dubé, Eric K. Moses, Joseph Hung, Kevin Huynh, John Beilby, Corey Giles, John Blangero
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 537-545 (2020)
J Lipid Res
J Lipid Res
CVD is the leading cause of death worldwide, and genetic investigations into the human lipidome may provide insight into CVD risk. The aim of this study was to estimate the heritability of circulating lipid species and their genetic correlation with
Autor:
Nobuyuki Shimozawa, Atsushi Yamashita, Kazuaki Yokoyama, Yuko Fujiwara, Kotaro Hama, Yasuhiro Hayashi, Shigeo Takashima
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 61, Iss 4, Pp 523-536 (2020)
Journal of Lipid Research, Vol 61, Iss 4, Pp 523-536 (2020)
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-
Autor:
Yuka Kadomatsu, Yuriko N. Koyanagi, Haruo Mikami, Michiaki Kubo, Mariko Naito, Norihiro Furusyo, Yuichiro Nishida, Asahi Hishida, Yoichi Sutoh, Atsushi Shimizu, Megumi Hara, Mineko Tsukamoto, Toshiro Takezaki, Teruhide Koyama, Chisato Shimanoe, Sakurako Katsuura-Kamano, Kenji Wakai, Tsuyoshi Hachiya, Yukihide Momozawa, Hirokazu Uemura, Naoyuki Takashima, Sadao Suzuki, Isao Oze, Rie Ibusuki, Kiyonori Kuriki, Aya Kadota, Hiroaki Ikezaki, Keitaro Tanaka, Yohko Nakamura, Masahiro Nakatochi, Nagato Kuriyama, Hiroko Nakagawa-Senda
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 86-94 (2020)
J Lipid Res
J Lipid Res
Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431
Autor:
Daisuke Saigusa, Anna Iwahori, Yoshikatsu Eto, Hiroshi Nittono, Hiroaki Yamaguchi, Peter E. Clayton, Isamu Jinnoh, Torayuki Okuyama, Nariyasu Mano, Aya Narita, Takashi Iida, Masamitsu Maekawa, Kousaku Ohno
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2074-2081 (2019)
J Lipid Res
J Lipid Res
Niemann-Pick disease type C (NPC) is an autosomal recessive disorder characterized by progressive nervous degeneration. Because of the diversity of clinical symptoms and onset age, the diagnosis of this disease is difficult. Therefore, biomarker test
Autor:
Moonil Kang, Joohon Sung
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2090-2101 (2019)
J Lipid Res
J Lipid Res
Dyslipidemia is a well-established risk factor for CVD. Studies suggest that similar fat accumulation in a given population might result in different levels of dyslipidemia risk among individuals; for example, despite similar or leaner body compositi
Autor:
Calvin Yeang, Marlys L. Koschinsky, Nicholas J. Viney, Joseph L. Witztum, Sotirios Tsimikas, Tanya T. Marar, Shuting Xia, Michael B. Boffa
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)
J Lipid Res
Journal of lipid research, vol 60, iss 12
J Lipid Res
Journal of lipid research, vol 60, iss 12
It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS