Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis

Autor: Marissa L. Maciej-Hulme, Jasper J. Van Gemst, Patience Sanderson, Angelique L. W. M. M. Rops, Jo H. Berden, Bart Smeets, I. Jonathan Amster, Ton J. Rabelink, Johan Van Der Vlag

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Proliferative forms of glomerulonephritis are characterized by the influx of leukocytes, albuminuria, and loss of kidney function. The glomerular endothelial glycocalyx is a thick carbohydrate layer that covers the endothelium and is comprised of hep

Externí odkaz: https://doaj.org/article/5060c46b8253413ba7b4953347efe22b

The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

Autor: Patience Sanderson, Thomas Mandel Clausen, Ana L. Saldanha, Yang Mao, Alejandro Gomez Toledo, Ali Salanti, Franklin E. Leach rd, Francesco Gatto, I. Jonathan Amster, Swati Choudhary, Charlotte B Spliid, Ismail Gögenur, Jeffrey D. Esko, Thor G. Theander, Tobias Gustavsson, Rasmus Peuliche Vogelsang

Publikováno v: Spliid, C B, Toledo, A G, Sanderson, P, Mao, Y, Gatto, F, Gustavsson, T, Choudhary, S, Saldanha, A L, Vogelsang, R P, Gögenur, I, Theander, T G, Leach, F E, Amster, I J, Esko, J D, Salanti, A & Clausen, T M 2021, ' The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility ', The Journal of Biological Chemistry, vol. 297, no. 6, 101391 . https://doi.org/10.1016/j.jbc.2021.101391
J Biol Chem

Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. Recombinant sub-fragments of VAR2CSA (rVAR2) have also been shown to bind specifically and with high affin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d01fe78602eda5c3b23bdd5e22350a
https://curis.ku.dk/ws/files/287629835/1_s2.0_S0021925821011972_main.pdf

Structural analysis of urinary glycosaminoglycans from healthy human subjects

Autor: Xiaorui Han, Fuming Zhang, I. Jonathan Amster, Patience Sanderson, Robert J. Linhardt, Yanlei Yu, Sara Nesheiwat, Lei Lin

Publikováno v: Glycobiology

Urinary glycosaminoglycans (GAGs) can reflect the health condition of a human being, and the GAGs composition can be directly related to various diseases. In order to effectively utilize such information, a detailed understanding of urinary GAGs in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20674d999cff98d943b82337f9b2fb89
https://pubmed.ncbi.nlm.nih.gov/31616929

Commercial Low Molecular Weight Heparins — Patent Ecosystem and Technology Paradigm for Quality Characterization.

Autor: Iqbal, Zarina, Sadaf, Saima

Publikováno v: Journal of Pharmaceutical Innovation; Jun2023, Vol. 18 Issue 2, p803-835, 33p

Researchers at Radboud University Medical Center Have Published New Study Findings on Molecular Bioscience (Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental...).

Publikováno v: Health & Medicine Week; 6/23/2023, p5769-5769, 1p