Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pathumwadee Intharathep"'
Autor:
Supot Hannongbua, Pornthep Sompornpisut, Yong Poovorawan, Maturos Malaisree, Nadtanet Nunthaboot, Pathumwadee Intharathep, Nopporn Kaiyawet, Thanyada Rungrotmongkol, Panita Decha
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 141:801-807
The current pandemic of the viral 2009 H1N1 influenza and its sustained human–human transmission has raised global concern for human health. The binding of the viral glycoprotein hemagglutinin (HA) and the human α-2,6-linked sialopentasaccharide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0f92ab9ba946380283c9922789600a
https://doi.org/10.1007/s00706-010-0319-z
https://doi.org/10.1007/s00706-010-0319-z
Autor:
Pathumwadee Intharathep, Pornthep Sompornpisut, Thanyarat Udommaneethanakit, Thanyada Rungrotmongkol, Maturos Malaisree, Nadtanet Nunthaboot, Supot Hannongbua
Publikováno v:
Biophysical Chemistry. 145:29-36
To reveal the source of oseltamivir-resistance in influenza (A/H5N1) mutants, the drug-target interactions at each functional group were investigated using MD/LIE simulations. Oseltamivir in the H274Y mutation primarily loses the electrostatic and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3372ed74e84f7fd780f1662768699b
https://doi.org/10.1016/j.bpc.2009.08.006
https://doi.org/10.1016/j.bpc.2009.08.006
Autor:
Pornthep Sompornpisut, Supot Hannongbua, Maturos Malaisree, Thanyada Rungrotmongkol, Nopphorn Kaiyawet, Yong Poovorawan, Nadtanet Nunthaboot, Sanchai Payungporn, Pathumwadee Intharathep
Publikováno v:
Biochemical and Biophysical Research Communications. 385:390-394
The recent outbreak of the novel strain of influenza A (H1N1) virus has raised a global concern of the future risk of a pandemic. To understand at the molecular level how this new H1N1 virus can be inhibited by the current anti-influenza drugs and wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31c5594f089b82dd406c821b82270d3
https://doi.org/10.1016/j.bbrc.2009.05.066
https://doi.org/10.1016/j.bbrc.2009.05.066
Autor:
Maturos Malaisree, Panita Decha, Sirirat Kokpol, Thanyada Rungrotmongkol, Supot Hannongbua, Pathumwadee Intharathep, Ornjira Aruksakunwong, Chittima Laohpongspaisan, Pornthep Sompornpisut, Vudhichai Parasuk, Somsak Pianwanit
Publikováno v:
Biophysical Journal. 95(1):128-134
The origin of the high pathogenicity of an emerging avian influenza H5N1 due to the –RRRKK– insertion at the cleavage loop of the hemagglutinin H5, was studied using the molecular dynamics technique, in comparison with those of the noninserted H5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cf2f1dbde5d2bcd13db532b3c8f816
Publikováno v:
Journal of Computational Chemistry. 26:1329-1338
A combined ab initio quantum mechanical/molecular mechanical (QM/MM) molecular dynamics simulation has been performed to investigate solvation structure and dynamics of NH(4) (+) in water. The most interesting region, the sphere includes an ammonium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62e5ff36ff2960ce0f67c99070498d8
https://doi.org/10.1002/jcc.20265
https://doi.org/10.1002/jcc.20265
Autor:
Peter Wolschann, Vudhichai Parasuk, Pornthep Sompornpisut, Supot Hannongbua, Pathumwadee Intharathep, Thanyarat Udommaneethanakit, Panita Decha
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 26(1)
Molecular dynamics simulations (MD) of the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) complexed with the four non-nucleoside reverse transcriptase inhibitors (NNRTIs): efavirenz (EFV), emivirine (EMV), etravirine (ETV) and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9983279dc3d3e8de65459c9ce5a78b65
https://pubmed.ncbi.nlm.nih.gov/20583854
https://pubmed.ncbi.nlm.nih.gov/20583854
Autor:
Supot Hannongbua, Pornthep Sompornpisut, Pathumwadee Intharathep, Nadtanet Nunthaboot, Panita Decha, Nopphorn Kaiyawet, Thanyada Rungrotmongkol, Teerakiat Kerdcharoen
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 26(2)
In order to understand how rimantadine (RMT) inhibits the proton conductance in the influenza A M2 channel via the recently proposed “allosteric mechanism”, molecular dynamics simulations were applied to the M2-tetrameric protein with four RMTs b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888db38b46c0d0f43aaa9c301674efc9
https://pubmed.ncbi.nlm.nih.gov/20583869
https://pubmed.ncbi.nlm.nih.gov/20583869
Autor:
Pornthep Sompornpisut, Eduardo Perozo, Benoît Roux, Pathumwadee Intharathep, Sudha Chakrapani
Direct structural insights on the fundamental mechanisms of permeation, selectivity, and gating remain unavailable for the Na + and Ca 2+ channel families. Here, we report the spectroscopic structural characterization of the isolated Voltage-Sensor D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567b56f2f8006cd97b6b021c62c700f0
https://europepmc.org/articles/PMC2851821/
https://europepmc.org/articles/PMC2851821/
Autor:
Pathumwadee Intharathep, Pornthep Sompornpisut, Maturos Malaisree, Chittima Laohpongspaisan, Thanyada Rungrotmongkol, Panita Decha, Ornjira Aruksakunwong, Supot Hannongbua
Publikováno v:
Journal of chemical information and modeling. 49(4)
Molecular dynamics simulations of the drug-resistant M2 mutants, A30T, S31N, and L26I, were carried out to investigate the inhibition of M2 activity using amantadine (AMT). The closed and open channel conformations were examined via non- and triply p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc423b0be2d03ea386b7fc1eb44c1482
https://pubmed.ncbi.nlm.nih.gov/19281265
https://pubmed.ncbi.nlm.nih.gov/19281265
Autor:
Pathumwadee Intharathep, Nadtanet Nunthaboot, Maturos Malaisree, Thanyada Rungrotmongkol, Pornthep Sompornpisut, Panita Decha, Ornjira Aruksakunwong, Supot Hannongbua
Publikováno v:
Amino acids. 37(4)
Molecular dynamics simulations were carried out for the mutant oseltamivir-NA complex, to provide detailed information on the oseltamivir-resistance resulting from the H274Y mutation in neuraminidase (NA) of avian influenza H5N1 viruses. In contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abd8537f1dd2cccc212b6a67cdfd35d
https://pubmed.ncbi.nlm.nih.gov/19002747
https://pubmed.ncbi.nlm.nih.gov/19002747