Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Pathik S. Brahmkshatriya"'
Publikováno v:
Chemical Biology & Drug Design. 92:1683-1691
A series of new pyrimidine-pyrazole hybrid molecules were designed as inhibitors of cyclin-dependent kinase 2. Designed compounds were docked using Glide and the compounds showing good score values and encouraging interactions with the residues were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300ce78bdf465454da212b604ceb45ed
https://doi.org/10.1111/cbdd.13334
https://doi.org/10.1111/cbdd.13334
Autor:
Pathik S. Brahmkshatriya, Popatbhai K. Patel, Mahesh T. Chhabria, Dharmraj N. Rana, Ashish K. Patel, Hemal M. Soni
Publikováno v:
International Journal of Organic Chemistry. :157-176
Various recent reports on Tuberculosis have alarmed an increase in the patient class and subsequent death rates across the globe. Over and above the spread of more dangerous and fatal forms of tuberculosis like MDR-TB i.e. multiple-drug resistance tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cf6383368a8d9e91d677685efe3beec
https://doi.org/10.4236/ijoc.2016.63017
https://doi.org/10.4236/ijoc.2016.63017
Autor:
Bhushan M. Mahajan, Mahesh T. Chhabria, Pathik S. Brahmkshatriya, Dharmraj N. Rana, Hemal M. Soni, Popatbhai K. Patel
Publikováno v:
Computational Chemistry. :45-53
A series of pyrazoline-based new heterocycles have recently been synthesized from our group where some of the compounds display potent anti-tubercular activity against Mycobacterium tuberculosis H37Rv. In order to further explore the potency of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c53d1d25cef317d5d95e56d8fdfa29
https://doi.org/10.4236/cc.2015.34006
https://doi.org/10.4236/cc.2015.34006
Autor:
Michaela Hylsová, Jindřich Fanfrlík, Kamil Paruch, Martin Lepšík, Pathik S. Brahmkshatriya, Aude Echalier, Vladimír Kryštof, Lenka Musilová, Benoit Carbain, Pavel Hobza, Radek Jorda, Cemal Köprülüoğlu, Susanta Haldar, Haresh Ajani
We present comprehensive testing of solvent representation in quantum mechanics (QM)-based scoring of protein-ligand affinities. To this aim, we prepared 21 new inhibitors of cyclin-dependent kinase 2 (CDK2) with the pyrazolo[1,5-a]pyrimidine core, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff55b4896483e77ca94a2153e7ccba7
https://ora.ox.ac.uk/objects/uuid:43f44ab7-8d22-446e-b571-e7a93d3341d3
https://ora.ox.ac.uk/objects/uuid:43f44ab7-8d22-446e-b571-e7a93d3341d3
Autor:
Jnyanaranjan Panda, Subas Chandra Dinda, B. Ravi Kumar, Pathik S. Brahmkshatriya, Biswa Mohan Sahoo
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 13:2076-2081
Epilepsy is one of the commonly occurring chronic neurological disorders which involves abnormal electrical impulses in the brain. It is characterized by the sudden loss of consciousness, followed by abnormal shaking of the body. Though there are var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd282161abdb2bcd4862acc6eeb6c7
https://doi.org/10.2174/13895575113136660099
https://doi.org/10.2174/13895575113136660099
Autor:
Jindřich Fanfrlík, Martin Lepšík, Michael Mareš, Martin Horn, Jan Řezáč, Pavel Hobza, Pathik S. Brahmkshatriya, Adéla Jílková
Publikováno v:
The Journal of Physical Chemistry B. 117:14973-14982
The quantum mechanics (QM)-based scoring function that we previously developed for the description of noncovalent binding in protein-ligand complexes has been modified and extended to treat covalent binding of inhibitory ligands. The enhancements are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416c350d9f2a18d4f794755a94902a87
https://doi.org/10.1021/jp409604n
https://doi.org/10.1021/jp409604n
Design, Green Synthesis, and Anti-Inflammatory Activity of Schiff Base of 1,3,4-oxadiazole Analogues
Autor:
Subas Chandra Dinda, Biswa Mohan Sahoo, Pathik S. Brahmkshatriya, Jnyanaranjan Panda, Bvv Ravi Kumar
Publikováno v:
Letters in Drug Design & Discovery. 11:82-89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70ab60726e84fb4d27495033ccc4222d
https://doi.org/10.2174/15701808113109990041
https://doi.org/10.2174/15701808113109990041
Publikováno v:
Medicinal Chemistry Research. 23:2218-2228
The present study is aimed at combining two well-known pharmacophores (pyrazoline and benzoxazole nucleus) to design and synthesize a series of new benzoxazole-based pyrazoline derivatives. In vitro antitubercular evaluation against Mycobacterium tub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22fba702cb687c6c4f437456e0b1f387
https://doi.org/10.1007/s00044-013-0815-x
https://doi.org/10.1007/s00044-013-0815-x
Publikováno v:
Medicinal Chemistry Research. 23:370-381
The present study is aimed at combining two well-known pharmacophores (pyrazoline and benzoxazole nucleus) to design and synthesize a series of substituted pyrazoline-based benzoxazole derivatives. In vitro antitubercular evaluation against Mycobacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d222a6b742db599713158fd75bcd97
https://doi.org/10.1007/s00044-013-0645-x
https://doi.org/10.1007/s00044-013-0645-x
Autor:
Mahesh T. Chhabria, Vipul M. Buha, Kishor H. Chikhalia, Bhushan M. Mahajan, Pathik S. Brahmkshatriya, Dharmaraj N. Rana, Nisha K. Shah
Publikováno v:
Medicinal Chemistry Research. 22:4096-4109
A novel series of 1-N-substituted-3-(4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea/thiourea derivatives (6a–6r) and 1-N-substituted-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c23ef3e56faf7adca7b4399b5f6c4b
https://doi.org/10.1007/s00044-012-0408-0
https://doi.org/10.1007/s00044-012-0408-0