Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pathanjali Kadiyala"'
Autor:
Rasa Santockyte, Thomas Mariannino, Richard Burrrell, Hamza Kandoussi, Patricia Paterson, Pathanjali Kadiyala, Hong Shen, Jianing Zeng, Kumar Shah, Yan Zhang, Punit Marathe, Petia Shipkova, Renuka Pillutla, Yurong Lai, John A. Easter, Robert Langish
Publikováno v:
Bioanalysis. 10:633-644
Aim: Coproporphyrins (CP-I and CP-III) have been identified as possible biomarkers to predict human hepatic organic anion-transporting polypeptides-mediated-drug-interactions for a new drug entering clinical development. Results: The method is applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c0e3a11a3e78851f3e18021f180eb2
https://doi.org/10.4155/bio-2017-0246
https://doi.org/10.4155/bio-2017-0246
Autor:
John Ryan, Anne-Françoise Aubry, Roger Demers, Hamza Kandoussi, Mark E. Arnold, Pathanjali Kadiyala, Chanda Baker, Richard C. Burrell, Bing He, Jianing Zeng, Timothy Eley, Laura Cojocaru, John A. Easter, Janice Pursley, Jian Wang, Hao Jiang
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 107:409-418
Dual or triple combination regimens of novel hepatitis C direct-acting antivirals (DAA, daclatasvir, asunaprevir, or beclabuvir) provide high sustained virological response rates and reduced frequency of resistance compared to clinical monotherapy. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e414b4e759e3185780cc9bce96f222
https://doi.org/10.1016/j.jpba.2015.01.027
https://doi.org/10.1016/j.jpba.2015.01.027
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c9221e9206ed0e57f44f10281d7ab
https://doi.org/10.1016/j.bmcl.2015.01.066
https://doi.org/10.1016/j.bmcl.2015.01.066
Autor:
Marc R. Yago, Hsin-Fang Wu, Leslie Z. Benet, Lynda A. Frassetto, Pathanjali Kadiyala, Kathleen Panter Faber, Xiaohui Xu
Publikováno v:
Pharmaceutical research, vol 34, iss 3
PurposeClinically relevant pharmacokinetic interactions exist between gastric acid-reducing agents and certain weakly basic drugs that rely on acidic environments for optimal oral absorption. In this study, we examine whether the administration of be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8c5a37038a0f1f4510f84c47f40121
https://pubmed.ncbi.nlm.nih.gov/28028768
https://pubmed.ncbi.nlm.nih.gov/28028768
Autor:
Andrew J. Tebben, Wayne Vaccaro, Xiaoxia Yang, Kim W. McIntyre, Steven Sheriff, Nelly Aranibar, Dharmpal S. Dodd, Stacey Skala, Zheng Yang, Dawn K. Stetsko, Patric M Davis, Theresa Ziemba, Suzanne J. Suchard, Dominique Potin, Karishma Patel, Bang-Chi Chen, Joel C. Barrish, Zili Xiao, Albert J. DelMonte, Scott H. Watterson, Murray McKinnon, David R. Tortolani, Praveen Balimane, Pathanjali Kadiyala, Punit Marathe, Huiping Zhang, Michele Launay, Deborah Lee, ChiehYing Y. Chang, T. G. Murali Dhar
Publikováno v:
Journal of Medicinal Chemistry. 53:3814-3830
Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or alpha(L)beta(2), belongs to the beta(2) integrin subfamily and is constitutively expressed on all leukocytes. The major ligands of LFA-1 include three intercellular adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d21c084dc54390adcd39bb85a2e9b0
https://doi.org/10.1021/jm100348u
https://doi.org/10.1021/jm100348u
Autor:
Lori Kunselman, Narayanan Hariharan, Pathanjali Kadiyala, Kenneth T. Locke, Denis E. Ryono, Thomas Harrity, Wei Wang, Arthur M. Doweyko, Randy Ponticiello, Liqun Gu, Pratik Devasthale, Lisa Zhang, Dennis Farrelly, Rachel Zebo, Michael Cap, Robert Zahler, Jodi K. Muckelbauer, Chiehying Chang, Cuixia Chu, Peter T. W. Cheng, Kevin O’Malley, Nathan Morgan, Litao Zhang, Jonathan Lippy, Vinayak Hosagrahara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1939-1944
A novel class of azetidinone acid-derived dual PPARalpha/gamma agonists has been synthesized for the treatment of diabetes and dyslipidemia. The preferred stereochemistry in this series for binding and functional agonist activity against both PPARalp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bfbf6fa4536695047baca135da5c60
https://doi.org/10.1016/j.bmcl.2008.01.126
https://doi.org/10.1016/j.bmcl.2008.01.126
Autor:
Naiyu Zheng, Hao Jiang, Jianing Zeng, Laura Cojocaru, Hamza Kandoussi, Timothy Eley, Mark E. Arnold, Bing He, Tushar Garimella, Anne-Françoise Aubry, Roger Demers, Pathanjali Kadiyala
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 119
Asunaprevir (BMS-650032) is a selective hepatitis C virus (HCV) NS3 protease inhibitor with potent activity against HCV genotypes 1, 4, 5 and 6. It has been developed in conjunction with direct-acting antiviral agents, in interferon- and ribavirin-fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1957efaaea70879a05d22e0df7f1ed42
https://pubmed.ncbi.nlm.nih.gov/26683987
https://pubmed.ncbi.nlm.nih.gov/26683987
Publikováno v:
Journal of Chromatography B. 830:270-277
Caco-2 cells are frequently used for screening compounds for their permeability characteristics and P-glycoprotein (P-gp) interaction potential. Bi-directional permeability studies performed on Caco-2 cells followed by analysis by HPLC-UV or LC-MS me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d6bde4a583c5d26f5788ab275a2470
https://doi.org/10.1016/j.jchromb.2005.11.006
https://doi.org/10.1016/j.jchromb.2005.11.006
Autor:
John Ryan, Timothy Eley, Mark E. Arnold, Richard C. Burrell, Anne-Françoise Aubry, Roger Demers, Pathanjali Kadiyala, Hao Jiang, Jianing Zeng, Hamza Kandoussi, Chanda Baker, Laura Cojocaru
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 107
BMS-791325 is a novel hepatitis C NS5B inhibitor which is currently in clinical development. To support pharmacokinetic (PK) assessments, sensitive, accurate, precise, and reproducible liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8e13db51d4a3280caea2be925ebe81
https://pubmed.ncbi.nlm.nih.gov/25562845
https://pubmed.ncbi.nlm.nih.gov/25562845
Autor:
Thomas Mariannino, Ishani Savant, William Mylott, Michael T. Furlong, Mark E. Arnold, Laura Scott, Vikram Roongta, Pathanjali Kadiyala, Moucun Yuan
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 926
Clopidogrel is prescribed for the treatment of Acute Coronary Syndrome and recent myocardial infarction, recent stroke, or established peripheral arterial disease. A sensitive and reliable high performance liquid chromatography-tandem mass spectromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7551d34326536581327d4dd426dbfe4
https://pubmed.ncbi.nlm.nih.gov/23542721
https://pubmed.ncbi.nlm.nih.gov/23542721