Minimal models of invasion and clonal selection in cancer

Autor: Paterson, Chay

In this thesis we develop minimal models of the relationship between motility, growth, and evolution of cancer cells. We utilise simple simulations of a population of individual cells in space to examine how changes in mechanical properties of invasi

Externí odkaz: http://arxiv.org/abs/2005.09592

Mathematical model of colorectal cancer initiation

Autor: Paterson, Chay, Clevers, Hans, Bozic, Ivana

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2020 Aug . 117(34), 20681-20688.

Externí odkaz: https://www.jstor.org/stable/26969040

On measuring selection in cancer from subclonal mutation frequencies.

Autor: Bozic, Ivana¹ ibozic@uw.edu, Paterson, Chay¹, Waclaw, Bartlomiej²

Publikováno v: PLoS Computational Biology. 9/26/2019, Vol. 15 Issue 9, p1-15. 15p. 1 Diagram, 3 Graphs.

An exactly solvable, spatial model of mutation accumulation in cancer

Autor: Paterson, Chay

Publikováno v: Paterson, C 2016, ' An exactly solvable, spatial model of mutation accumulation in cancer ', Scientific Reports . https://doi.org/10.1038/srep39511

One of the hallmarks of cancer is the accumulation of driver mutations which increase the net reproductive rate of cancer cells and allow them to spread. This process has been studied in mathematical models of well mixed populations, and in computer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::d656021327e56f3decd4ff44109956b9
https://doi.org/10.1038/srep39511

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.