Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Patel Tajesh Jayprakash"'
Autor:
Christian M. Gampe, Jingzhou Li, Patel Tajesh Jayprakash, Jakal Amin, Charles Babu, Lihua Yang, Eugene Liu, Andrei Golosov, Katsumasa Nakajima, David Nettleton, Patrick C. Reid, Lauren G. Monovich, Flyer Alec
Publikováno v:
Journal of Medicinal Chemistry. 64:2622-2633
Advances in the design of permeable peptides and in the synthesis of large arrays of macrocyclic peptides with diverse amino acids have evolved on parallel but independent tracks. Less precedent combines their respective attributes, thereby limiting
Autor:
Catherine E Garrison, Thomas Tamsett, Yishan Sun, Mitsunori Kato, Patel Tajesh Jayprakash, Wendy Guan, Tejas P. Pathak
Publikováno v:
ACS Med Chem Lett
[Image: see text] Beta-pompilidotoxin (β-PMTX) is a 13-amino acid wasp venom peptide that activates human neuronal sodium channel Na(V)1.1 with weak activity (40% activation at 3.3 μM of β-PMTX). Through rational design of β-PMTX analogs, we have
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-