Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patel Lewis A"'
Autor:
Joseph D. Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L. Wilbur, Keith A. Otto, Yanyun Chen, Min Song, Jonathan P. Riley, Hsiu-Chiung Yang, Nichole A. Reynolds, Steven D. Kahl, Anjana Patel Lewis, Christopher Groshong, Russell E. Madsen, Kris Conners, Jayana P. Lineswala, Tarun Gheyi, Melbert-Brian Decipulo Saflor, Matthew R. Lee, Jordi Benach, Kenton A. Baker, Chahrzad Montrose-Rafizadeh, Michael J. Genin, Anne R. Miller, Chafiq Hamdouchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
GPR40 is a G-protein coupled receptor that binds to free fatty acids, mediating insulin and incretin secretion. Here, the authors present the crystal structure of human GPR40 with an agonist bound to an allosteric site located near the lipid-rich reg
Externí odkaz:
https://doaj.org/article/5d745f39e74e44df919e15e9433e1c33
Autor:
Min Song, Christopher Groshong, Frances Lu, Yanyun Chen, Steven D. Kahl, Chahrzad Montrose-Rafizadeh, Jayana Pankaj Lineswala, Melbert-Brian Decipulo Saflor, Nichole A. Reynolds, Michaël Genin, Anjana Patel Lewis, Tarun Gheyi, Hsiu-Chiung Yang, Russell E. Madsen, Betty Chau, Chafiq Hamdouchi, Matthew R. Lee, Kenton A. Baker, Anne Reifel Miller, Joseph D. Ho, Keith A. Otto, Kelly L. Wilbur, K. Conners, Jordi Benach, Jonathan P. Riley, Logan Rodgers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of GPR40-TAK-875 complex revealed the allosteric site for the partial agonist. Here we report the 2.76-Å
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e03e48d8920a531cb284d811890c17
https://doi.org/10.1038/s41467-017-01240-w
https://doi.org/10.1038/s41467-017-01240-w
Autor:
Steven D. Kahl, Kelly L. Wilbur, Warshawsky Alan M, Jayana Pankaj Lineswala, Siddaramaiah Cr, Pranab Maiti, Sweetana Stephanie Ann, Diseroad Benjamin Alan, Lisa A. Adams, Yanyun Chen, Richard W. Zink, Anne Reifel Miller, Grace L. Neathery, Anjana Patel Lewis, Over Cabrera, Alison N. Campbell, Guemalli R. Cardona, Nathan Yumibe, Keyue Chen, Keith A. Otto, Cecilia Bouaichi, Xiaosu Ma, Chafiq Hamdouchi, Amy C. DeBaillie, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 61(3)
As a part of our program to identify potent GPR40 agonists capable of being dosed orally once daily in humans, we incorporated fused heterocycles into our recently disclosed spiropiperidine and tetrahydroquinoline acid derivatives 1, 2, and 3 with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba33126a14f55ea8f6b1d4d12011e1a1
https://pubmed.ncbi.nlm.nih.gov/29236497
https://pubmed.ncbi.nlm.nih.gov/29236497
Autor:
Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 59(24)
The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e874164fca96fc6edd42ba967fc574b
https://pubmed.ncbi.nlm.nih.gov/27749056
https://pubmed.ncbi.nlm.nih.gov/27749056
Autor:
Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M., DeBaillie, Amy C., Otto, Keith A., Wilbur, Kelly L., Kahl, Steven D., Patel Lewis, Anjana, Cardona, Guemalli R., Zink, Richard W., Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P., Neathery, Grace L., Bouaichi, Cecilia, Diseroad, Benjamin A., Campbell, Alison N., Sweetana, Stephanie A., Adams, Lisa A., Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P., Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel
Publikováno v:
Journal of Medicinal Chemistry; 20240101, Issue: Preprints
Autor:
Hamdouchi, Chafiq, Kahl, Steven D., Patel Lewis, Anjana, Cardona, Guemalli R., Zink, Richard W., Keyue Chen, Eessalu, Thomas E., Ficorilli, James V., Marcelo, Marialuisa C., Otto, Keith A., Wilbur, Kelly L., Lineswala, Jayana P., Piper, Jared L., Coffey, D. Scott, Sweetana, Stephanie A., Haas, Joseph V., Brooks, Dawn A., Pratt, Edward J., Belin, Ruth M., Deeg, Mark A.
Publikováno v:
Journal of Medicinal Chemistry; Dec2016, Vol. 59 Issue 24, p10891-10916, 26p
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