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Proliferation and Survival of T-cell Acute Lymphoblastic Leukaemia Depends on mTOR-regulated Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides

Autor: Stanulović, Vesna S., Reed, Michelle A.C., Patani, Hemalvi, Potluri, Sandeep, Georgiadou, Eleni, Roberts, Jennie, Sarkar, Sovan, Pratt, Guy, Jones, Alan M., Günther, Ulrich, Ludwig, Christian, Hoogenkamp, Maarten

Summary T-cell acute lymphoblastic leukaemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients relapse and die from the disease. To improve patient outcome new drugs are needed. With the aim to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::6daf4d072be91980ed0bfdfbecd6376b

Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

Autor: Gabriella Ficz, Hemalvi Patani, Saul A. Teijeiro, David Oxley, Pedro R. Cutillas, Duncan Sproul, Michael D. Rushton, Jonathan Higham

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Patani, H, Rushton, M D, Higham, J, Teijeiro, S A, Oxley, D, Cutillas, P, Sproul, D & Ficz, G 2020, ' Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation ', Nature Communications . https://doi.org/10.1038/s41467-020-17269-3

Epigenetic reprogramming is a cancer hallmark, but how it unfolds during early neoplastic events and its role in carcinogenesis and cancer progression is not fully understood. Here we show that resetting from primed to naïve human pluripotency resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd26a4fd9e8619babf7162f3ac8407e