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Autor:
Carmen S. Alvarez, Taveras Arthur G, Bancha Vibulbhan, Doll Ronald J, Viyyoor M. Girijavallabhan, Birendra N. Pramanik, Mathew S. Bryant, Donna Carr, Ashit K. Ganguly, Linda James, Alan K. Mallams, Chao Jianping, Adriano Afonso, Jeff Deskus, Ming Liu, Lynn Wang, Randall R. Rossman, Lalwani Tarik, Paul Kirschmeier, Cynthia J. Vaccaro, Larry Heimark, Stacy W. Remiszewski, F. George Njoroge, W. Robert Bishop, Robert Patton, Jocelyn del Rosario, Pat Pinto, and Amin A. Nomeir
Publikováno v:
Journal of Medicinal Chemistry. 42:2651-2661
Farnesyl protein transferase (FPT) is a promising target for the development of cancer chemotherapeutics because it is responsible for the farnesylation of oncogenic p21 Ras proteins which are found in nearly 30% of all human cancers and necessary fo