Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Pat P Ongusaha"'
Autor:
Doug A Medvetz, Damir Khabibullin, Venkatesh Hariharan, Pat P Ongusaha, Elena A Goncharova, Tanja Schlechter, Thomas N Darling, Ilse Hofmann, Vera P Krymskaya, James K Liao, Hayden Huang, Elizabeth P Henske
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47842 (2012)
Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical interaction between folli
Externí odkaz:
https://doaj.org/article/ee25e5953e1d4c7f83be50684daa1507
Autor:
G. Paolo Dotto, Anne J. Ridley, Sarah A. Boswell, Pat P. Ongusaha, Hyung Gu Kim, Stuart A. Aaronson, Channing J. Der, Sam W. Lee, Young-Bum Kim
The Rho family of GTPases regulates many aspects of cellular behavior through alterations to the actin cytoskeleton . The majority of the Rho family proteins function as molecular switches cycling between the active, GTP-bound and the inactive, GDP-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c9f158539ae7748edc02fe23f3223
https://europepmc.org/articles/PMC6644033/
https://europepmc.org/articles/PMC6644033/
Autor:
Rajkumar Lakshmanaswamy, A Perkins, Alexander Hackathorn, Brad A. Bryan, C Doty, K Masterjohn, James K. Liao, Carrie Spencer, Arunkumar Arumugam, Pat P. Ongusaha, J Montalvo, Dianne C. Mitchell
Publikováno v:
Current Molecular Medicine
The serine/threonine protein kinase paralogs ROCK1 & 2 have been implicated as essential modulators of angiogenesis; however their paralog-specific roles in endothelial function are unknown. shRNA knockdown of ROCK1 or 2 in endothelial cells resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10032bb39bdd4003ef7d20109c9e4e09
https://doi.org/10.2174/1566524011307010205
https://doi.org/10.2174/1566524011307010205
Autor:
Hannah Schmitt, Qian Zhou, Karol Kamiński, James K. Liao, Pat P. Ongusaha, Martin Moser, Xinbing Han, Takuhito Shoji, Christoph Bode, Goo Taeg Oh, Yu Mei, Kunzhong Zhang
Publikováno v:
Circulation. 126:2236-2247
Background— Macrophages play a central role in the development of atherosclerosis. However, the signaling pathways that regulate their function are not well understood. The Rho-associated coiled-coil-containing kinases (ROCK1 and ROCK2) are serine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dae4d3d6ddf5b3516981e117ccc565
https://doi.org/10.1161/circulationaha.111.086041
https://doi.org/10.1161/circulationaha.111.086041
Autor:
Zhibin Wang, Gangqing Hu, Maite Huarte, Yang Shi, Madathia Sarkissian, Thomas M. Roberts, Leonardo Brizuela, Pat P. Ongusaha, Benjamin A. Garcia, Hui-Jun Lim, D. Benjamin Gordon, Keji Zhao, Arindam Bhattacharjee, Hank H. Qi, Fei Lan, Nasser K. Yaghi, Michelle Gonzales
Publikováno v:
Nature
Mutations in the PHF8 gene, which encodes the plant homeo domain (PHD) finger protein 8, are connected to X-linked mental retardation associated with cleft lip and cleft palate. Two groups now report that the PHF8 protein is a histone demethylase wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b579ff801ab59c097c7b238b883b8ef3
https://doi.org/10.1038/nature09261
https://doi.org/10.1038/nature09261
Autor:
Lauren Brown-Endres, Sam W. Lee, Wafik S. El-Deiry, Takao Ide, Kiki Chu, Pat P. Ongusaha, Stuart A. Aaronson, Takao Ohtsuka
Publikováno v:
Molecular Cell. 36:379-392
The p53 tumor suppressor protein has a well-established role in cell-fate decision-making processes. However, recent discoveries indicate that p53 has a non-tumor-suppressive role. Here we identify guanidinoacetate methyltransferase (GAMT), an enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0621d437a5080927b1241afa41d472e0
https://doi.org/10.1016/j.molcel.2009.09.031
https://doi.org/10.1016/j.molcel.2009.09.031
Autor:
Outi Pakkanen, Sam W. Lee, Johanna Myllyharju, Junmin Peng, Hank H. Qi, Yang Shi, Dongmei Cheng, Pat P. Ongusaha, Yujiang Shi
Publikováno v:
Nature. 455:421-424
Argonaute proteins are a part of a larger RNA interference (RNAi) complex, RISC, in which they mediate cleavage of target mRNAs. In this study, Shi and colleagues show that Ago2 interacts with and is hydroxylated by type I collagen prolyl-4-hydroxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f60228be4cd12c87d2f149b930a023a
https://doi.org/10.1038/nature07186
https://doi.org/10.1038/nature07186
Autor:
Xiaoyong Yang, Jerrold M. Olefsky, Robert H. Michell, Seth J. Field, W. Venus So, Joyce C. Havstad, Jeffrey E. Kudlow, Pat P. Ongusaha, Philip D.G. Miles, Ronald M. Evans, Fengxue Zhang
Publikováno v:
Nature. 451:964-969
Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification of cytoplasmic and nuclear proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc). This tandem system serves as a nutrient sensor to couple system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8b865479422f4593ef55dbed0a21e5
https://doi.org/10.1038/nature06668
https://doi.org/10.1038/nature06668
Publikováno v:
Journal of Biological Chemistry. 282:4850-4858
RhoE, a p53 target gene, was identified as a critical factor for the survival of human keratinocytes in response to UVB. The Rho family of GTPases regulates many aspects of cellular behavior through alterations to the actin cytoskeleton, acting as mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e620105f537bef90ff9d6270f9a774b8
https://doi.org/10.1074/jbc.m610532200
https://doi.org/10.1074/jbc.m610532200
Autor:
Chu-Xia Deng, Hiroshi Katayama, Mutsuko Ouchi, Yohji A. Minamishima, Sam W. Lee, Kaori Sasai, Nobuko Fujiuchi, Toru Ouchi, Subrata Sen, Pat P. Ongusaha
Aurora-A/BTAK/STK15 localizes to the centrosome in the G(2)-M phase, and its kinase activity regulates the G(2) to M transition of the cell cycle. Previous studies have shown that the BRCA1 breast cancer tumor suppressor also localizes to the centros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ae65f1a8f6608ac3d1a089aa7e6e93
https://europepmc.org/articles/PMC5399520/
https://europepmc.org/articles/PMC5399520/