Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin-resistant canine model.

Autor: Kabir M; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Porter J; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Stefanovski D; University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA., Paszkiewicz RL; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Piccinini F; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Woolcott OO; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Yang H; Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Gopaul VS; Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Stiles L; Department of Endocrinology, David Geffen School of Medicine at the University of California, Los Angeles, California, USA., Kolka CM; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Publikováno v: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2023 Jul; Vol. 31 (7), pp. 1798-1811. Date of Electronic Publication: 2023 May 23.

Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells.

Autor: Tucci J; Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, United States., Chen T; Division of Pediatric Endocrinology, University of California Los Angeles (UCLA) Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA, United States., Margulis K; Department of Chemistry, Stanford University, Stanford, CA, United States.; The Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel., Orgel E; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, United States., Paszkiewicz RL; Division of Pediatric Endocrinology, University of California Los Angeles (UCLA) Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA, United States., Cohen MD; Division of Pediatric Endocrinology, University of California Los Angeles (UCLA) Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA, United States., Oberley MJ; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA, United States., Wahhab R; Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, United States., Jones AE; Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States., Divakaruni AS; Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States., Hsu CC; Department of Chemistry, Stanford University, Stanford, CA, United States.; Department of Chemistry, National Taiwan University, Taipei, Taiwan., Noll SE; Department of Chemistry, Stanford University, Stanford, CA, United States., Sheng X; Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, United States., Zare RN; Department of Chemistry, Stanford University, Stanford, CA, United States., Mittelman SD; Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, United States.; Division of Pediatric Endocrinology, University of California Los Angeles (UCLA) Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2021 Apr 22; Vol. 11, pp. 665763. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).

A Peripheral CB1R Antagonist Increases Lipolysis, Oxygen Consumption Rate, and Markers of Beiging in 3T3-L1 Adipocytes Similar to RIM, Suggesting that Central Effects Can Be Avoided.

Autor: Paszkiewicz RL; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Bergman RN; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Santos RS; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Frank AP; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Woolcott OO; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Iyer MS; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Stefanovski D; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Clegg DJ; The College of Nursing and Health Professions, Drexel University, Philadelphia, PA 19104, USA., Kabir M; Sports Spectacular Diabetes and Obesity Wellness and Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Sep 10; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 10.

Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia.

Autor: Sea JL; Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Orgel E; Division of Hematology, Oncology, Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA., Chen T; Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Paszkiewicz RL; Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Krall AS; Department of Biological Chemistry and the Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA., Oberley MJ; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, CA, USA., Stiles L; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Mittelman SD; Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Publikováno v: Leukemia & lymphoma [Leuk Lymphoma] 2020 Feb; Vol. 61 (2), pp. 420-428. Date of Electronic Publication: 2019 Sep 16.

Assessment of hepatic insulin extraction from in vivo surrogate methods of insulin clearance measurement.

Autor: Asare-Bediako I; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Paszkiewicz RL; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Kim SP; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Woolcott OO; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Kolka CM; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Burch M; Cedars-Sinai Medical Center, Department of Surgery , Los Angeles, California., Kabir M; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Piccinini F; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute , Los Angeles, California.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2018 Oct 01; Vol. 315 (4), pp. E605-E612. Date of Electronic Publication: 2018 Mar 06.