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Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

Autor: Loncaster, J. A., Adrian Harris, Davidson, S. E., Logue, J. P., Hunter, R. D., Wycoff, C. C., Pastorek, J., Ratcliffe, P. J., Stratford, I. J., West, C. M. L.

Publikováno v: Scopus-Elsevier
Web of Science

There is increasing evidence that hypoxia-regulated gene expression influences tumor aggressiveness, contributing to the poorer outcome of patients with hypoxic tumors. The role of the transcriptional complex hypoxia-inducible factor-1 as an importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0cfc8d4f0e33d017f9993e0b4d381278
https://ora.ox.ac.uk/objects/uuid:6341cb55-fe26-49f5-9594-9b0564b525ec

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

Autor: Alterio V, Hilvo M, Di Fiore A, Supuran C.T., Pan P, Parkkil S, Scaloni A, Pastorek J, Pastorekova S, Scozzafava A, Monti SM, De Simone G., PEDONE, CARLO

Carbonic anhydrase (CA) IX is a plasma membrane-assocd. member of the .alpha.-CA enzyme family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a prognostic factor in several human cancers. An aberrant increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::f438be3070a881ce63f17f435c1c2a1a
http://hdl.handle.net/11588/362503

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

Autor: Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT

Publikováno v: Bioorganic & medicinal chemistry
19 (2009): 5825–5828.
info:cnr-pdr/source/autori:Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT/titolo:The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors/doi:/rivista:Bioorganic & medicinal chemistry (Print)/anno:2009/pagina_da:5825/pagina_a:5828/intervallo_pagine:5825–5828/volume:19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::951f6c2a6a5ab199963f2d6953c11ca0
http://www.cnr.it/prodotto/i/14104