Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

Autor: Moreno-Grau, S, de Rojas, I, Hernandez, I, Quintela, I, Montrreal, L, Alegret, M, Hernandez-Olasagarre, B, Madrid, L, Gonzalez-Perez, A, Maronas, O, Rosende-Roca, M, Mauleon, A, Vargas, L, Lafuente, A, Abdelnour, C, Rodriguez-Gomez, O, Gil, S, Santos-Santos, MA, Espinosa, A, Ortega, G, Sanabria, A, Perez-Cordon, A, Canabate, P, Moreno, M, Preckler, S, Ruiz, S, Aguilera, N, Pineda, JA, Macias, J, Alarcon-Martin, E, Sotolongo-Grau, O, Marquie, M, Monte-Rubio, G, Valero, S, Benaque, A, Clarimon, J, Bullido, MJ, Garcia-Ribas, G, Pastor, P, Sanchez-Juan, P, Alvarez, V, Pinol-Ripoll, G, Garcia-Alberca, JM, Royo, JL, Franco, E, Mir, P, Calero, M, Medina, M, Rabano, A, Avila, J, Antunez, C, Real, LM, Orellana, A, Carracedo, A, Saez, ME, Tarraga, L, Boada, M, Ruiz, A, Alarcon, E, Buendia, M, Corbaton, A, Diego, S, Gailhajenet, A, Gonzalez, PG, Guitart, M, Ibarria, M, Martin, E, Martinez, MT, Pancho, A, Peleja, E, Serrano-Rios, M, Adarmes-Gomez, AD, Alvarez, I, Amer-Ferrer, G, Antequera, M, Baquero, M, Bernal, M, Blesa, R, Buiza-Rueda, D, Burguera, JA, Carrillo, F, Carrion-Claro, M, Casajeros, MJ, Cruz-Gamero, JM, de Pancorbo, MM, del Ser, T, Diez-Fairen, M, Fortea, J, Frank-Garcia, A, Madrona, SG, Gomez-Garre, P, Hevilla, S, Jesus, S, Espinosa, MAL, Lage, C, Legaz, A, Lleo, A, de Munain, AL, Lopez-Garcia, S, Macias, D, Manzanares, S, Marin, M, Marin-Munoz, J, Marin, T, Montes, AM, Martinez, B, Martinez, C, Martinez, V, Alvarez, PML, Iriarte, MM, Menendez-Gonzalez, M, Molinuevo, JL, Pastor, AB, Tur, JP, Perinan-Tocino, T, de Asua, DR, Rodrigo, S, Rodriguez-Rodriguez, E, Diaz, RSD, Sastre, E, Vicente, MP, Vivancos, L

Publikováno v: Alzheimers & Dementia
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::80de9c354126d75a0eb24f7af068cbdd
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2407

Turismo: ¿desarrollo duradero?

Autor: Pastor Abreu, Antonio

Publikováno v: PASOS Revista de Turismo y Patrimonio Cultural, Vol 2, Iss 1, Pp 145-147 (2004)

Opiniones y Ensayos

Externí odkaz: https://doaj.org/article/a2b256dd3c6e40228686f9a5d32f0691

Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles.

Autor: Sánchez-Juan P; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, 28029 Madrid, Spain., Valeriano-Lorenzo E; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Ruiz-González A; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Pastor AB; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Rodrigo Lara H; Banco de Cerebros de la Región de Murcia, Neuropathology Department, 30120 Murcia, Spain., López-González F; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Zea-Sevilla MA; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Valentí M; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Frades B; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Ruiz P; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Saiz L; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Burgueño-García I; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Calero M; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, 28029 Madrid, Spain.; Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain., Del Ser T; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain., Rábano A; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Research Platforms, 28031 Madrid, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, 28029 Madrid, Spain.

Publikováno v: Brain : a journal of neurology [Brain] 2024 May 03; Vol. 147 (5), pp. 1667-1679.

Non-invasive biomarkers for mild cognitive impairment and Alzheimer's disease.

Autor: Botello-Marabotto M; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Valencia, Spain; Unidad Mixta de Investigación en Nanomedicina y Sensores, Instituto de Investigación Sanitaria La Fe (IISLAFE), Universitat Politècnica de València, Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain., Martínez-Bisbal MC; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Valencia, Spain; Unidad Mixta de Investigación en Nanomedicina y Sensores, Instituto de Investigación Sanitaria La Fe (IISLAFE), Universitat Politècnica de València, Valencia, Spain; Departamento de Química-Física, Universitat de València, Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain. Electronic address: carmen.martinez-bisbal@uv.es., Calero M; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; CIEN Foundation, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain; Instituto de Salud Carlos III, Madrid, Spain., Bernardos A; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain; Departamento de Química, Universitat Politècnica de València, Valencia, Spain., Pastor AB; CIEN Foundation, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain., Medina M; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; CIEN Foundation, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain., Martínez-Máñez R; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Valencia, Spain; Unidad Mixta de Investigación en Nanomedicina y Sensores, Instituto de Investigación Sanitaria La Fe (IISLAFE), Universitat Politècnica de València, Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain; Departamento de Química, Universitat Politècnica de València, Valencia, Spain.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2023 Oct 15; Vol. 187, pp. 106312. Date of Electronic Publication: 2023 Sep 26.

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Autor: Bellenguez C; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr., Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Jansen IE; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Kleineidam L; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Moreno-Grau S; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Oxford University, Oxford, UK., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Campos-Martin R; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Grenier-Boley B; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Andrade V; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Holmans PA; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Boland A; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Damotte V; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Costa MR; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil., Kuulasmaa T; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., de Rojas I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Yaqub A; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Prokic I; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Chapuis J; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Ahmad S; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; LACDR, Leiden, the Netherlands., Giedraitis V; Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Aarsland D; Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.; Institute of Psychiatry, Psychology & Neuroscience, London, UK., Garcia-Gonzalez P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Abdelnour C; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alarcón-Martín E; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain., Alcolea D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Alegret M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alvarez I; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Armstrong NJ; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Tsolaki A; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Antúnez C; Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Appollonio I; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Neurology Unit, San Gerardo Hospital, Monza, Italy., Arcaro M; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy., Archetti S; Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy., Pastor AA; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Athanasiu L; NORMENT Centre, University of Oslo, Oslo, Norway., Bailly H; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Banaj N; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Baquero M; Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Unit of Neurology, University of Parma and AOU, Parma, Italy.; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Beiser A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Pastor AB; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Below JE; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Benchek P; Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Benussi L; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Berr C; Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France., Besse C; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Bessi V; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Binetti G; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; MAC - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Bizarro A; Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy., Blesa R; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Boada M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Borroni B; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Boschi S; Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy., Bossù P; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Bråthen G; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Bressler J; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Bresner C; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Brookes KJ; Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Brusco LI; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.; Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A., Buenos Aires, Argentina.; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Buiza-Rueda D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Bûrger K; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Burholt V; Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.; Wales Centre for Ageing & Dementia Research, Swansea University, Wales, New Zealand., Bush WS; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Calero M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.; UFIEC, Instituto de Salud Carlos III, Madrid, Spain., Cantwell LB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chene G; INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; Pole Santé Publique, CHU de Bordeaux, Bordeaux, France., Chung J; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA., Cuccaro ML; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Carracedo Á; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain., Cecchetti R; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Cervera-Carles L; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Charbonnier C; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Chen HH; Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA., Chillotti C; Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy., Ciccone S; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Claassen JAHR; Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands., Clark C; Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland., Conti E; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy., Corma-Gómez A; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Costantini E; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Custodero C; University of Bari, 'A. Moro', Bary, Italy., Daian D; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Dalmasso MC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Daniele A; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Dardiotis E; School of Medicine, University of Thessaly, Larissa, Greece., Dartigues JF; Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France., de Deyn PP; Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands., de Paiva Lopes K; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., de Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Debette S; Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Del Ser T; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Denning N; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., DeStefano A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Diehl-Schmid J; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Diez-Fairen M; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Rossi PD; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Djurovic S; NORMENT Centre, University of Oslo, Oslo, Norway., Duron E; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Düzel E; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Dufouil C; INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; Pole Santé Publique, CHU de Bordeaux, Bordeaux, France., Eiriksdottir G; Icelandic Heart Association, Kopovagur, Iceland., Engelborghs S; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, UZ Brussel, Brussels, Belgium., Escott-Price V; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Espinosa A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ewers M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Fabrizio T; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Farotti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Fenoglio C; University of Milan, Milan, Italy., Fernández-Fuertes M; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Ferrari R; Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Ferreira CB; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Ferri E; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Fin B; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Fischer P; Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria., Fladby T; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fließbach K; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Fongang B; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Fornage M; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Fortea J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Fostinelli S; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Fox NC; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Franco-Macías E; Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Bullido MJ; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain., Frank-García A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Hospital Universitario la Paz, Madrid, Spain., Froelich L; Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany., Fulton-Howard B; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA., Galimberti D; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., García-Alberca JM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., García-González P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Garcia-Madrona S; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Garcia-Ribas G; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Giegling I; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Giorgio G; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Goate AM; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goldhardt O; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Gomez-Fonseca D; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., González-Pérez A; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Graff C; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden., Grande G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Green E; Institute of Public Health, University of Cambridge, Cambridge, UK., Grimmer T; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Grunin M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Gudnason V; Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Guetta-Baranes T; Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK., Haapasalo A; AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hadjigeorgiou G; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus., Haines JL; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Hamilton-Nelson KL; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Hampel H; GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Hanon O; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Hardy J; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Hartmann AM; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany., Harwood J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Helisalmi S; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Heneka MT; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Hernández I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Herrmann MJ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Holmes C; Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK., Holstege H; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Vilas RH; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Hulsman M; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Humphrey J; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Biessels GJ; Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands., Jian X; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Johansson C; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Jun GR; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA., Kastumata Y; Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA., Kauwe J; Department of Biology, Brigham Young University, Provo, UT, USA., Kehoe PG; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kilander L; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Ståhlbom AK; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Kivipelto M; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.; Research & Development, UnitStockholms Sjukhem, Stockholm, Sweden., Koivisto A; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Department of Neurosciences, University of Helsinki and Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland., Kornhuber J; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Kosmidis MH; Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Kuksa PP; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kunkle BW; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus., Kuzma AB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lage C; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Laukka EJ; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.; Stockholm Gerontology Research Center, Stockholm, Sweden., Launer L; Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA., Lauria A; Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy., Lee CY; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lehtisalo J; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Lerch O; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia., Lleó A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Longstreth W Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Lopez O; Framingham Heart Study, Framingham, MA, USA., de Munain AL; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain., Love S; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Löwemark M; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Luckcuck L; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Lunetta KL; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Ma Y; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Neurology, Columbia University, New York, NY, USA., Macías J; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., MacLeod CA; School of Health Sciences, Bangor University, Bangor, UK., Maier W; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Mangialasche F; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Spallazzi M; Unit of Neurology, University of Parma and AOU, Parma, Italy., Marquié M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marshall R; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Montes AM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Hospital Universitario la Paz, Madrid, Spain., Rodríguez CM; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA., Mead S; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Medina M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Meggy A; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Mehrabian S; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Mendoza S; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., Menéndez-González M; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Mir P; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Mol M; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Molina-Porcel L; Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain., Montrreal L; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Morelli L; Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina., Moreno F; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain., Morgan K; Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK., Mosley T; Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Muchnik C; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.; Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Ngandu T; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Nicolas G; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Olaso R; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Orellana A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Orsini M; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Ortega G; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Padovani A; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Paolo C; DIMEC, University of Parma, Parma, Italy., Papenberg G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Parnetti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Pasquier F; Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France., Pastor P; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Peloso G; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Pérez-Cordón A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Pérez-Tur J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Institut de Biomedicina de València-CSIC CIBERNED, València, Spain.; Unitat Mixta de de Neurología y Genética, Institut d'Investigació Sanitària La Fe, València, Spain., Pericard P; US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France., Peters O; Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Pineda JA; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Polak T; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Popp J; CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité, Charitéplatz 1, Berlin, Germany., Puerta R; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Quenez O; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Quintela I; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Thomassen JQ; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Rábano A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Rainero I; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Rajabli F; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Ramakers I; Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Reinders MJT; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.; Taub Institute, Columbia University, New York, NY, USA., Reyes-Dumeyer D; Department of Neurology, Columbia University, New York, NY, USA.; Taub Institute, Columbia University, New York, NY, USA., Ridge P; Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Riederer P; Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany., Roberto N; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Rodriguez-Rodriguez E; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Rongve A; Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.; Institute of Clinical Medicine (K1), The University of Bergen, Bergen, Norway., Allende IR; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Rosende-Roca M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Royo JL; Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain., Rubino E; Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Sáez ME; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Sakka P; Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece., Saltvedt I; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Sanabria Á; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sánchez-Arjona MB; Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain., Juan PS; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Sánchez-Valle R; Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain., Sando SB; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway., Sarnowski C; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Satizabal CL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Scamosci M; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Scarmeas N; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Scarpini E; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Scherbaum N; LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Schneider A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Selbæk G; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Seripa D; Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy., Serrano M; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain., Sha J; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shadrin AA; NORMENT Centre, University of Oslo, Oslo, Norway., Skrobot O; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Slifer S; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Snijders GJL; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland., Solfrizzi V; University of Bari, 'A. Moro', Bary, Italy., Solomon A; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Song Y; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Sotolongo-Grau O; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Spalletta G; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Spottke A; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Squassina A; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Stordal E; Department of Psychiatry, Namsos Hospital, Namsos, Norway., Tartan JP; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Tárraga L; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Tesí N; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Thomas T; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Tosto G; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Traykov L; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Tremolizzo L; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Neurology Unit, San Gerardo Hospital, Monza, Italy., Tybjærg-Hansen A; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Uitterlinden A; Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands., Ullgren A; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Ulstein I; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Valero S; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valladares O; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Broeckhoven CV; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Vance J; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., van der Lugt A; Department of Neurology, ErasmusMC, Rotterdam, the Netherlands., Dongen JV; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., van Rooij J; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.; Department of Neurology, ErasmusMC, Rotterdam, the Netherlands., van Swieten J; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.; Neurology Department, University Hospitals Leuven, Leuven, Belgium., Verhey F; Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands., Vidal JS; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Vogelgsang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA., Vyhnalek M; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia., Wagner M; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Wallon D; Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Wang LS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wang R; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Weinhold L; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Medical Science Department, iBiMED, Aveiro, Portugal., Windle G; School of Health Sciences, Bangor University, Bangor, UK., Woods B; School of Health Sciences, Bangor University, Bangor, UK., Yannakoulia M; Department of Nutrition and Diatetics, Harokopio University, Athens, Greece., Zare H; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Zhao Y; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zhang X; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zhu C; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zulaica M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain., Farrer LA; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Psaty BM; Framingham Heart Study, Framingham, MA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Health Service, University of Washington, Seattle, WA, USA., Ghanbari M; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Raj T; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sachdev P; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Mather K; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Jessen F; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Ikram MA; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., de Mendonça A; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Hort J; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia., Tsolaki M; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Pericak-Vance MA; AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Amouyel P; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Williams J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Frikke-Schmidt R; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Clarimon J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Deleuze JF; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Rossi G; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Seshadri S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway., Ingelsson M; Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Hiltunen M; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil., Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., van Duijn CM; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Oxford University, Oxford, UK., Sims R; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Ruiz A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ramirez A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Lambert JC; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Jean-Charles.Lambert@pasteur-lille.fr.

Publikováno v: Nature genetics [Nat Genet] 2022 Apr; Vol. 54 (4), pp. 412-436. Date of Electronic Publication: 2022 Apr 04.