Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver.

Autor: Passman AM; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Haughey MJ; School of Mathematical Sciences, Queen Mary University of London, London, UK., Carlotti E; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Williams MJ; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Cereser B; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Lin ML; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Devkumar S; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Gabriel JP; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Gringeri E; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Cillo U; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Russo FP; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Hoare M; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., ChinAleong J; Histopathology, Barts Health NHS Trust, London, UK., Jansen M; Department of Cellular Pathology, University College London, London, UK; UCL Cancer Centre, University College London, London, UK., Wright NA; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kocher HM; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK; Cancer Tissue Bank, Barts Cancer Institute, Queen Mary University of London, London, UK; Barts and the London HPB Centre, The Royal London Hospital, Barts Health NHS Trust, London, UK., Huang W; School of Mathematical Sciences, Queen Mary University of London, London, UK; Group of Theoretical Biology, The State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, China., Alison MR; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., McDonald SAC; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. Electronic address: s.a.mcdonald@qmul.ac.uk.

Publikováno v: Journal of hepatology [J Hepatol] 2023 Aug; Vol. 79 (2), pp. 417-432. Date of Electronic Publication: 2023 Apr 21.

Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model.

Autor: Passman AM; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Strauss RP; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., McSpadden SB; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Finch-Edmondson M; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Andrewartha N; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Woo KH; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Diepeveen LA; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Zhao W; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia., Fernández-Irigoyen J; Proteored-ISCIII, Proteomics Platform, Navarrabiomed, Navarra Health Department, Navarra Institute for Health Research (IdiSNA), Public University of Navarra, 31008 Pamplona, Spain., Santamaría E; Proteored-ISCIII, Proteomics Platform, Navarrabiomed, Navarra Health Department, Navarra Institute for Health Research (IdiSNA), Public University of Navarra, 31008 Pamplona, Spain., Medina-Ruiz L; Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Center, University of Glasgow, Glasgow G12 8TA, UK., Szpakowska M; Immuno-Pharmacology and Interactomics Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg., Chevigné A; Immuno-Pharmacology and Interactomics Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg., Park H; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.; UWA Medical School, University of Western Australia, Crawley, WA 6009, Australia., Carlessi R; Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia., Tirnitz-Parker JEE; Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia., Blanco JR; Infectious Diseases Area, Hospital San Pedro-Center for Biomedical Research of La Rioja, 26006 Logroño, Spain., London R; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Callus BA; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Comparative Genomics, Murdoch University, Murdoch, WA 6150, Australia., Elsegood CL; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.; UWA Medical School, University of Western Australia, Crawley, WA 6009, Australia.; Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia., Baker MV; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia., Martínez A; Oncology Area, Center for Biomedical Research of La Rioja, 26006 Logroño, Spain., Yeoh GCT; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.; Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Ochoa-Callejero L; Oncology Area, Center for Biomedical Research of La Rioja, 26006 Logroño, Spain.

Publikováno v: Cancers [Cancers (Basel)] 2021 Sep 30; Vol. 13 (19). Date of Electronic Publication: 2021 Sep 30.

Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib.

Autor: Woo K; The Centre for Medical Research, The Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Stewart SG; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Kong GS; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Finch-Edmondson ML; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Dwyer BJ; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, The Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Yeung SY; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Abraham LJ; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Kampmann SS; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Diepeveen LA; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, The Perkins Institute of Medical Research, Nedlands, WA 6009, Australia., Passman AM; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia., Elsegood CL; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia., Tirnitz-Parker JE; School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; School of Medicine and Pharmacology, University of Western Australia, Fremantle, WA 6959, Australia., Callus BA; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, WA 6959, Australia., Olynyk JK; Department of Gastroenterology & Hepatology, Fiona Stanley Hospital, Bull Creek, WA, Australia; School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; School of Veterinary Sciences, Murdoch University, Murdoch, WA, Australia., Yeoh GC; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, The Perkins Institute of Medical Research, Nedlands, WA 6009, Australia. Electronic address: george.yeoh@uwa.edu.au.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2016 Sep 14; Vol. 120, pp. 275-83. Date of Electronic Publication: 2016 Mar 09.

A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice.

Autor: Passman AM; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., Strauss RP; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., McSpadden SB; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., Finch-Edmondson ML; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., Woo KH; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., Diepeveen LA; Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., London R; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia., Callus BA; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia School of Health Sciences, The University of Notre Dame Australia, Fremantle, Western Australia 6959, Australia., Yeoh GC; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia Cancer and Cell Biology Division, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia George.Yeoh@uwa.edu.au.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2015 Dec; Vol. 8 (12), pp. 1635-41. Date of Electronic Publication: 2015 Oct 23.

Sub-cellular localisation studies may spuriously detect the Yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function.

Autor: Finch ML; School of Chemistry and Biochemistry, University of Western Australia, Crawley, Western Australia, 6009, Australia., Passman AM; School of Chemistry and Biochemistry, University of Western Australia, Crawley, Western Australia, 6009, Australia., Strauss RP; School of Chemistry and Biochemistry, University of Western Australia, Crawley, Western Australia, 6009, Australia., Yeoh GC; School of Chemistry and Biochemistry, University of Western Australia, Crawley, Western Australia, 6009, Australia; Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, the University of Western Australia, Crawley, Western Australia, 6009, Australia., Callus BA; School of Chemistry and Biochemistry, University of Western Australia, Crawley, Western Australia, 6009, Australia.

Publikováno v: PloS one [PLoS One] 2015 Feb 06; Vol. 10 (2), pp. e0114813. Date of Electronic Publication: 2015 Feb 06 (Print Publication: 2015).