Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.

Autor: Sáez-Cirión A; Viral Reservoirs and Immune Control Unit, Université Paris Cité, Institut Pasteur, Paris, France. asier.saez-cirion@pasteur.fr.; HIV Inflammation and Persistence Unit, Université Paris Cité, Institut Pasteur, Paris, France. asier.saez-cirion@pasteur.fr., Mamez AC; Division of Hematology, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland., Avettand-Fenoel V; Institut Cochin-CNRS 8104/INSERM U1016/Université de Paris, Paris, France.; LI2RSO, Université d'Orléans, Orléans, France.; Virologie, CHU d'Orléans, Orléans, France., Nabergoj M; Institut Central des Hôpitaux, Sion, Switzerland., Passaes C; Viral Reservoirs and Immune Control Unit, Université Paris Cité, Institut Pasteur, Paris, France.; HIV Inflammation and Persistence Unit, Université Paris Cité, Institut Pasteur, Paris, France., Thoueille P; Service of Clinical Pharmacology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Service of Clinical Pharmacology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Decosterd L; Service of Clinical Pharmacology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Hentzien M; HIV/AIDS Unit, Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland., Perdomo-Celis F; HIV Inflammation and Persistence Unit, Université Paris Cité, Institut Pasteur, Paris, France., Salgado M; IrsiCaixa, Badalona, Spain.; Germans Trias i Pujol Research Institute, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Nijhuis M; Translational Virology Research Group, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.; HIV Pathogenesis Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mélard A; Institut Cochin-CNRS 8104/INSERM U1016/Université de Paris, Paris, France., Gardiennet E; Institut Cochin-CNRS 8104/INSERM U1016/Université de Paris, Paris, France., Lorin V; Humoral Immunology Unit, Inserm U1222, Université Paris Cité, Institut Pasteur, Paris, France., Monceaux V; Viral Reservoirs and Immune Control Unit, Université Paris Cité, Institut Pasteur, Paris, France.; HIV Inflammation and Persistence Unit, Université Paris Cité, Institut Pasteur, Paris, France., Chapel A; Viral Reservoirs and Immune Control Unit, Université Paris Cité, Institut Pasteur, Paris, France.; HIV Inflammation and Persistence Unit, Université Paris Cité, Institut Pasteur, Paris, France., Gourvès M; Viral Reservoirs and Immune Control Unit, Université Paris Cité, Institut Pasteur, Paris, France., Lechartier M; Viral Reservoirs and Immune Control Unit, Université Paris Cité, Institut Pasteur, Paris, France., Mouquet H; Humoral Immunology Unit, Inserm U1222, Université Paris Cité, Institut Pasteur, Paris, France., Wensing A; Translational Virology Research Group, Department of Global Public Health & Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Martinez-Picado J; IrsiCaixa, Badalona, Spain.; Germans Trias i Pujol Research Institute, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.; UVic-UCC, Vic, Spain.; ICREA, Barcelona, Spain., Yerly S; Laboratory of Virology, Geneva University Hospitals, Geneva, Switzerland., Rougemont M; Unaffiliated, Geneva, Switzerland., Calmy A; HIV/AIDS Unit, Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland. alexandra.calmy@hug.ch.

Publikováno v: Nature medicine [Nat Med] 2024 Dec; Vol. 30 (12), pp. 3544-3554. Date of Electronic Publication: 2024 Sep 02.

Author Correction: High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells.

Autor: De La Torre Tarazona E; Infectious Diseases Department, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University Hospital Ramón y Cajal, Madrid, Spain. erick.delatorretarazona@gmail.com.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. erick.delatorretarazona@gmail.com., Passaes C; HIV, Inflammation and Persistence Unit, Institut Pasteur, Université Paris Cité, Paris, France.; Viral Reservoirs and Immune Control Unit, Institut Pasteur, Université Paris Cité, Paris, France., Moreno S; Infectious Diseases Department, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University Hospital Ramón y Cajal, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Department of Medicine, Alcalá University, Madrid, Spain., Sáez-Cirión A; HIV, Inflammation and Persistence Unit, Institut Pasteur, Université Paris Cité, Paris, France.; Viral Reservoirs and Immune Control Unit, Institut Pasteur, Université Paris Cité, Paris, France., Alcamí J; AIDS Immunopathogenesis Unit, National Center of Microbiology, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Publikováno v: Scientific reports [Sci Rep] 2024 Jul 17; Vol. 14 (1), pp. 16545. Date of Electronic Publication: 2024 Jul 17.

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In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.

Autor: Jensen BO; Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. bjoern-erikole.jensen@med.uni-duesseldorf.de., Knops E; Institute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany., Cords L; Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lübke N; Institute of Virology, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Salgado M; IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Center for Biomedical Research in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.; Germans Trias i Pujol Research Institute, Barcelona, Spain., Busman-Sahay K; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Estes JD; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Huyveneers LEP; Translational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Perdomo-Celis F; Institut Pasteur, Paris Cité University, HIV Inflammation and Persistence, Paris, France., Wittner M; Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Gálvez C; IrsiCaixa AIDS Research Institute, Barcelona, Spain., Mummert C; Infectious Diseases and Immunodeficiency Section, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.; Bavarian Nordic, Martinsried, Germany., Passaes C; Institut Pasteur, Paris Cité University, HIV Inflammation and Persistence, Paris, France., Eberhard JM; Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; Helmholtz Center for Infection Research, Helmholtz Institute for One Health, Greifswald, Germany., Münk C; Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Hauber I; Leibniz Institute of Virology, Hamburg, Germany., Hauber J; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; Leibniz Institute of Virology, Hamburg, Germany., Heger E; Institute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany., De Clercq J; HIV Cure Research Center and Department of General Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium., Vandekerckhove L; HIV Cure Research Center and Department of General Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium., Bergmann S; Infectious Diseases and Immunodeficiency Section, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Dunay GA; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; Leibniz Institute of Virology, Hamburg, Germany.; University Children's Research, UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Klein F; Institute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany., Häussinger D; Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Fischer JC; Institute for Transplant Diagnostics and Cell Therapeutics, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Nachtkamp K; Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany., Timm J; Institute of Virology, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Kaiser R; Institute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany., Harrer T; Infectious Diseases and Immunodeficiency Section, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Nijhuis M; Translational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Sáez-Cirión A; Institut Pasteur, Paris Cité University, HIV Inflammation and Persistence, Paris, France., Schulze Zur Wiesch J; Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. j.schulze-zur-wiesch@uke.de.; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany. j.schulze-zur-wiesch@uke.de., Wensing AMJ; Translational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.; Ezintsha, University of the Witwatersrand, Johannesburg, South Africa., Martinez-Picado J; IrsiCaixa AIDS Research Institute, Barcelona, Spain.; Center for Biomedical Research in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.; University of Vic-Central University of Catalonia, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies, Barcelona, Spain., Kobbe G; Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany.

Publikováno v: Nature medicine [Nat Med] 2023 Mar; Vol. 29 (3), pp. 583-587. Date of Electronic Publication: 2023 Feb 20.