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Dieta e microbiota intestinale: Due facce di una stessa medaglia?

Autor: Schiumerini, Ramona, Pasqui, Francesca, Festi, Davide

Gut microbiota is a complex ecosystem, resident in the digestive tract, exerting multiple functions that can have a significant impact on the pathophysiology of the host organism. The composition and functions of this "superorganism" are influenced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::9ff5524bd51f6059461ee914a39112c9
http://hdl.handle.net/11585/661313

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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

Autor: Dennis, Siobhan, Pasqui, Francesca, Colvin, Ellen M, Sanger, Helen, Mogg, Adrian J, Felder, Christian C, Broad, Lisa M, Fitzjohn, Steve, Isaac, John T R, Mellor, Jack

Publikováno v: Cerebral Cortex (New York, NY)
Dennis, S, Pasqui, F, Colvin, E M, Sanger, H, Mogg, A J, Felder, C C, Broad, L M, Fitzjohn, S, Isaac, J T R & Mellor, J 2016, ' Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus ', Cerebral Cortex, vol. 26, no. 1, pp. 414-426 . https://doi.org/10.1093/cercor/bhv227

Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory. It has been hypothesized that the principal mechanism by which M1Rs influence spatial memo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::256f6ee39f80fbd0a70529e3753ff5c6
http://europepmc.org/articles/PMC4677984

Forebrain-selective AMPA-receptor antagonism guided by TARPλ 3-8 as an antiepileptic mechanism

Autor: Kato, Akihiko S., Burris, Kevin D., Gardinier, Kevin M., Gernert, Douglas L., Porter, Warren J., Reel, Jon, Ding, Chunjin, Tu, Yuan, Schober, Douglas A., Lee, Matthew R., Heinz, Beverly A., Fitch, Thomas E., Gleason, Scott D., Catlow, John T., Yu, Hong, Fitzjohn, Stephen M., Pasqui, Francesca, Wang, He, Qian, Yuewei, Sher, Emanuele, Zwart, Ruud, Wafford, Keith A., Rasmussen, Kurt, Ornstein, Paul L., Isaac, John T.R., Nisenbaum, Eric S., Bredt, David S., Witkin, Jeffrey M.

Publikováno v: Kato, A S, Burris, K D, Gardinier, K M, Gernert, D L, Porter, W J, Reel, J, Ding, C, Tu, Y, Schober, D A, Lee, M R, Heinz, B A, Fitch, T E, Gleason, S D, Catlow, J T, Yu, H, Fitzjohn, S M, Pasqui, F, Wang, H, Qian, Y, Sher, E, Zwart, R, Wafford, K A, Rasmussen, K, Ornstein, P L, Isaac, J T R, Nisenbaum, E S, Bredt, D S & Witkin, J M 2016, ' Forebrain-selective AMPA-receptor antagonism guided by TARPλ 3-8 as an antiepileptic mechanism ', Nature Medicine, vol. 22, no. 12, pp. 1496-1501 . https://doi.org/10.1038/nm.4221

Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Alth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::7bc7ef35de0cdc494d2e07d26fc9f1f8
https://research-information.bris.ac.uk/en/publications/2a72c95c-feee-43b2-8322-d4ed72a55710