Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Pasquale Molinaro"'
Autor:
Natascia Guida, Angelo Serani, Luca Sanguigno, Luigi Mascolo, Ornella Cuomo, Salvatore Fioriniello, Domenico Marano, Floriana Della Ragione, Serenella Anzilotti, Paola Brancaccio, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Background REST (Repressor‐Element 1 [RE1]‐silencing transcription factor) inhibits Na+/Ca2+exchanger‐1 (Ncx1) transcription in neurons through the binding of RE1 site on brain promoter (Br) after stroke. We identified a new putative RE1 site i
Externí odkaz:
https://doaj.org/article/368c7c109bcc45fdb6e0e75da03f5e5d
Autor:
Pasquale Molinaro, Luca Sanguigno, Antonella Casamassa, Valeria Valsecchi, Rossana Sirabella, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9177 (2023)
The downstream regulatory element antagonist modulator (DREAM) is a multifunctional Ca2+-sensitive protein exerting a dual mechanism of action to regulate several Ca2+-dependent processes. Upon sumoylation, DREAM enters in nucleus where it downregula
Externí odkaz:
https://doaj.org/article/936623b46cb245e19c8c539af367c1f3
Autor:
Ornella Cuomo, Pasquale Cepparulo, Serenella Anzilotti, Angelo Serani, Rossana Sirabella, Paola Brancaccio, Natascia Guida, Valeria Valsecchi, Antonio Vinciguerra, Pasquale Molinaro, Luigi Formisano, Lucio Annunziato, Giuseppe Pignataro, MD PhD
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 1063-1071 (2019)
It has been demonstrated that the K+-dependent Na+/Ca2+ exchanger, NCKX2, is a new promising stroke neuroprotective target. However, because no pharmacological activator of NCKX2 is still available, microRNA (miRNA) may represent an alternative metho
Externí odkaz:
https://doaj.org/article/d5de7584c93d4d1a9c8576dbbe4a279e
Autor:
Natascia Guida, Luca Sanguigno, Luigi Mascolo, Lucrezia Calabrese, Angelo Serani, Pasquale Molinaro, C. Geoffrey Lau, Lucio Annunziato, Luigi Formisano
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (RES
Externí odkaz:
https://doaj.org/article/89a302f1e8e84e34bd6a9666029f77d1
Autor:
Beatrice Severino, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Giuseppe Caliendo, Vincenzo Santagada, Elisa Magli, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Natalícia J. Antunes, Julio Rojas-Moscoso, Noedi L. de Freitas, Gustavo D. Mendes, Gilberto De Nucci
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na+/Ca2+ exchanger (NC
Externí odkaz:
https://doaj.org/article/786b7753f733401cb60d56c62520bbfb
Autor:
Luigi Formisano, Natascia Guida, Valeria Valsecchi, Giuseppe Pignataro, Antonio Vinciguerra, Anna Pannaccione, Agnese Secondo, Francesca Boscia, Pasquale Molinaro, Maria Jose Sisalli, Rossana Sirabella, Antonella Casamassa, Lorella M.T. Canzoniero, Gianfranco Di Renzo, Lucio Annunziato
Publikováno v:
Neurobiology of Disease, Vol 50, Iss , Pp 76-85 (2013)
The Na+–Ca2+ exchanger 1 (NCX1), a bidirectional transporter that mediates the electrogenic exchange of one calcium ion for three sodium ions across the plasmamembrane, is known to be involved in brain ischemia. Since the RE1-silencing transcriptio
Externí odkaz:
https://doaj.org/article/71cab51d5cb34e53a92f400340fb6f14
Autor:
Luca Sanguigno, Natascia Guida, Serenella Anzilotti, Ornella Cuomo, Luigi Mascolo, Angelo Serani, Paola Brancaccio, Giuseppina Pennacchio, Ester Licastro, Giuseppe Pignataro, Pasquale Molinaro, Lucio Annunziato, Luigi Formisano
Publikováno v:
International Journal of Biological Sciences. 19:2695-2710
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e7a78bd37a8c98d2fc6ba0e30de8c3
https://doi.org/10.7150/ijbs.80735
https://doi.org/10.7150/ijbs.80735
Autor:
Giuseppe Pignataro, Natascia Guida, Luigi Formisano, Paola Brancaccio, Serenella Anzilotti, Ornella Cuomo, Pasquale Molinaro, Lucio Annunziato, Angelo Serani, Luigi Mascolo
Publikováno v:
Stroke. 52:3680-3691
Background and Purpose: NCX3 (Na + -Ca 2+ exchanger 3) plays a relevant role in stroke; indeed its pharmacological blockade or its genetic ablation exacerbates brain ischemic damage, whereas its upregulation takes part in the neuroprotection elicited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd56b0fe015c1cc2a05a59697a6687f
https://doi.org/10.1161/strokeaha.121.034637
https://doi.org/10.1161/strokeaha.121.034637
Autor:
Angelo Serani, Agnese Secondo, Roselia Ciccone, Ferdinando Fiorino, Gianfranco Di Renzo, Anna Pannaccione, Beatrice Severino, Lucia D’Esposito, Lucrezia Calabrese, Serenella Anzilotti, Francesco Frecentese, Silvia Natale, Tiziana Petrozziello, A.G. Sadile, Antonio Vinciguerra, Pasquale Molinaro, Simona Cabib, Ornella Cuomo, Lucio Annunziato
Publikováno v:
Molecular Neurobiology. 57:2358-2376
The Na+/Ca2+ exchanger 1 (NCX1) participates in the maintenance of neuronal Na+ and Ca2+ homeostasis, and it is highly expressed at synapse level of some brain areas involved in learning and memory processes, including the hippocampus, cortex, and am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ed5f555615022a09b241cfc7ff27c3
https://doi.org/10.1007/s12035-020-01888-4
https://doi.org/10.1007/s12035-020-01888-4
Autor:
Valentina Tedeschi, Maria Josè Sisalli, Anna Pannaccione, Ilaria Piccialli, Pasquale Molinaro, Lucio Annunziato, Agnese Secondo
Excessive calcium (Ca2+) release from the endoplasmic reticulum (ER) represents an important hallmark of several neurodegenerative diseases. ER is recharged from Ca2+ through the so-called Store-Operated Calcium Entry (SOCE) thus providing Ca2+ signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8135d7f03b3014b8d4f8c2010c8729
http://hdl.handle.net/11588/870086
http://hdl.handle.net/11588/870086
