Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Pasquale Miglionico"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract GPCRs are master regulators of cell signaling by transducing extracellular stimuli into the cell via selective coupling to intracellular G-proteins. Here we present a computational analysis of the structural determinants of G-protein-couplin
Externí odkaz:
https://doaj.org/article/da49a4ca45f84e08b3e832e14af71d34
We present a comprehensive computational analysis of available 3D GPCR-G-protein complexes to inspect the structural determinants of G-protein-coupling selectivity.Analysis of the residue contacts at interaction interfaces has revealed a network of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16dda4392acb0f2d4bcc2e574ca5382c
https://doi.org/10.1101/2022.09.24.508774
https://doi.org/10.1101/2022.09.24.508774
Autor:
Marin Matic, Gurdeep Singh, Francesco Carli, Natalia De Oliveira Rosa, Pasquale Miglionico, Lorenzo Magni, J Silvio Gutkind, Robert B Russell, Asuka Inoue, Francesco Raimondi
Publikováno v:
Nucleic acids research.
In this study we show that protein language models can encode structural and functional information of GPCR sequences that can be used to predict their signaling and functional repertoire. We used the ESM1b protein embeddings as features and the bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a24d9cd85f848a642527ffa23d12093
https://pubmed.ncbi.nlm.nih.gov/35639758
https://pubmed.ncbi.nlm.nih.gov/35639758
A ranked tree topology is a tree topology with a temporal ordering of its coalescence events. Under the multispecies coalescent model, we consider ranked gene tree topologies realized along the branches of ranked species trees, where one gene copy is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa00c3e03375a053299680636be614c
http://hdl.handle.net/11568/1011199
http://hdl.handle.net/11568/1011199