Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Pasquale Laise"'
Autor:
Pasquale Laise, Megan L. Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, Theodore Alexandrov, Marianna Kruithof-de Julio, Andrea Califano, Steeve Boulant, Mariano J. Alvarez
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.
Externí odkaz:
https://doaj.org/article/2848e83b0ed146a0b6c215d5176e0325
Autor:
Serena Buontempo, Pasquale Laise, James M. Hughes, Sebastiano Trattaro, Vivek Das, Chantal Rencurel, Giuseppe Testa
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and
Externí odkaz:
https://doaj.org/article/364545fc5725480b9422d154b7645c28
Autor:
Pietro Lo Riso, Carlo Emanuele Villa, Gilles Gasparoni, Andrea Vingiani, Raffaele Luongo, Anna Manfredi, Annemarie Jungmann, Alessia Bertolotti, Francesca Borgo, Annalisa Garbi, Michela Lupia, Pasquale Laise, Vivek Das, Giancarlo Pruneri, Giuseppe Viale, Nicoletta Colombo, Teresa Manzo, Luigi Nezi, Ugo Cavallaro, Davide Cacchiarelli, Jörn Walter, Giuseppe Testa
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-20 (2020)
Abstract Background High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies.
Externí odkaz:
https://doaj.org/article/aa3c17c5bc5549b2bf586e26c47db96e
Autor:
Elena Signaroldi, Pasquale Laise, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta, Giuseppe Testa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of th
Externí odkaz:
https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec
Autor:
Giulia Fragola, Pierre-Luc Germain, Pasquale Laise, Alessandro Cuomo, Alessandro Blasimme, Fridolin Gross, Elena Signaroldi, Gabriele Bucci, Cesar Sommer, Giancarlo Pruneri, Giovanni Mazzarol, Tiziana Bonaldi, Gustavo Mostoslavsky, Stefano Casola, Giuseppe Testa
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003292 (2013)
Transcription factor (TF)-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been p
Externí odkaz:
https://doaj.org/article/2c49370df92c4602afaa012c6b3686cd
Publikováno v:
AIP Advances, Vol 2, Iss 1, Pp 011201-011201-11 (2012)
The epithelial-mesenchymal transition (EMT) consists in a morphological change in epithelial cells characterized by the loss of the cell adhesion and the acquisition of mesenchymal phenotype. This process plays a crucial role in the embryonic develop
Externí odkaz:
https://doaj.org/article/c6dbc7c4d9a24177b1443b3232801e3c
Autor:
Moritz Middelhoff, Giovanni Valenti, Lorenzo Tomassoni, Yosuke Ochiai, Bryana Belin, Ryota Takahashi, Ermanno Malagola, Henrik Nienhüser, Michael Finlayson, Yoku Hayakawa, Leah B. Zamechek, Bernhard W. Renz, C. Benedikt Westphalen, Michael Quante, Kara G. Margolis, Peter A. Sims, Pasquale Laise, Andrea Califano, Meenakshi Rao, Michael D. Gershon, Timothy C. Wang
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Intestinal ganglionic cells in the adult enteric nervous system (ENS) are continually exposed to stimuli from the surrounding microenvironment and need at times to respond to disturbed homeostasis following acute intestinal injury. The kinase DCLK1 a
Autor:
David A. Tuveson, Paul Robson, Andrea Califano, Elizabeth M. Jaffee, Jonathan Preall, Youngkyu Park, Christopher L. Wolfgang, Yuan Hao, Kenneth H. Yu, Dannielle D. Engle, Todd D. Armstrong, Santhosh Sivajothi, Matthew S. Lucito, Giulia Biffi, Pascal Belleau, Jonathan A. Teinor, Richard A. Burkhart, Elise T. Courtois, William F. Flynn, Pasquale Laise, Mohan Bolisetty, Ela Elyada
Supplementary Table S20 shows the marker genes of the different clusters in the fibroblast-enriched KPC analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3b6bcec656f62f607a93bd27233b87
https://doi.org/10.1158/2159-8290.22536689.v1
https://doi.org/10.1158/2159-8290.22536689.v1
Autor:
David A. Tuveson, Paul Robson, Andrea Califano, Elizabeth M. Jaffee, Jonathan Preall, Youngkyu Park, Christopher L. Wolfgang, Yuan Hao, Kenneth H. Yu, Dannielle D. Engle, Todd D. Armstrong, Santhosh Sivajothi, Matthew S. Lucito, Giulia Biffi, Pascal Belleau, Jonathan A. Teinor, Richard A. Burkhart, Elise T. Courtois, William F. Flynn, Pasquale Laise, Mohan Bolisetty, Ela Elyada
Supplementary Table S1 shows patient information, Supplementary Table S2 shows cell numbers analyzed from each human PDAC sample, Supplementary Table S3 shows statistics of the clustering analysis of the human PDAC single cell RNA sequencing, Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537a71e519160c84fb5e054e05d8c6ba
https://doi.org/10.1158/2159-8290.22536665.v1
https://doi.org/10.1158/2159-8290.22536665.v1
Autor:
David A. Tuveson, Paul Robson, Andrea Califano, Elizabeth M. Jaffee, Jonathan Preall, Youngkyu Park, Christopher L. Wolfgang, Yuan Hao, Kenneth H. Yu, Dannielle D. Engle, Todd D. Armstrong, Santhosh Sivajothi, Matthew S. Lucito, Giulia Biffi, Pascal Belleau, Jonathan A. Teinor, Richard A. Burkhart, Elise T. Courtois, William F. Flynn, Pasquale Laise, Mohan Bolisetty, Ela Elyada
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05668eed082a8964c856d8103f8ad225
https://doi.org/10.1158/2159-8290.c.6548204.v1
https://doi.org/10.1158/2159-8290.c.6548204.v1