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LB15. SER-109, an Investigational Microbiome Therapeutic, Reduces Abundance of Antimicrobial Resistance Genes in Patients with Recurrent Clostridioides difficile Infection (rCDI) after Standard-of-Care Antibiotics

Autor: Timothy J Straub, Liyang Diao, Christopher Ford, Matthew Sims, Thomas J Louie, Charles Berenson, Colleen S Kraft, Stuart H Cohen, Alla Paskovaty, Mary-Jane Lombardo, Barbara McGovern, Lisa von Moltke, Matt Henn

Publikováno v: Open Forum Infectious Diseases. 8:S812-S813

Background The gastrointestinal microbiota is the first line of defense against colonization with antimicrobial resistant (AR) bacteria, particularly in vulnerable hosts with frequent antibiotic exposure. In a double-blind Phase 3 trial of rCDI patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7ab5fb532491f315accbba5c0be1c9c
https://doi.org/10.1093/ofid/ofab466.1651

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Efficacy and safety of SER-109, an investigational microbiome therapeutic for recurrent clostridioides difficile infection: Data from ECOSPOR III, a phase 3 randomized trial

Autor: Alla Paskovaty, Charles S. Berenson, Thomas J. Louie, Elaine Wang, David A. Lombardi, Lisa von Moltke

Publikováno v: Journal of Clinical Oncology. 40:12113-12113

12113 Background: Patients with malignancies are at increased risk for recurrent Clostridioides difficile infection (rCDI) due to their immunosuppressed state and frequent exposure to antibiotics and chemotherapy. These factors disrupt the gut microb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba4803a57b2606fc465d218e3c808234
https://doi.org/10.1200/jco.2022.40.16_suppl.12113

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Akademický článek

A multidisciplinary approach to antimicrobial stewardship: evolution into the 21st century

Autor: Paskovaty, A. ^*, Pflomm, J.M., Myke, N., Seo, S.K.

Publikováno v: In International Journal of Antimicrobial Agents 2005 25(1):1-10

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Impact of QuickFISH in addition to antimicrobial stewardship on vancomycin use and resource utilization in cancer patients with coagulase-negative staphylococcal blood cultures

Autor: Kenneth Seier, Elyn Riedel, Alla Paskovaty, Sejal Morjaria, Yi-Wei Tang, Nina Cohen, Susan K. Seo, Zivile Gedrimaite, N. E. Babady

Publikováno v: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 24(12)

To evaluate the impact of rapidly identifying coagulase-negative staphylococci (CoNS) from positive blood cultures combined with an established antimicrobial stewardship (AS) programme at a tertiary cancer centre.We compared cancer patients ≥18 yea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a979fa2cb06163852b3a70f44461fbb
https://pubmed.ncbi.nlm.nih.gov/29549061

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Multicentre study of posaconazole delayed-release tablet serum level and association with hepatotoxicity and QTc prolongation

Autor: Jennifer Pisano, Jennifer L. Steinbeck, Susan K. Seo, Anthony J. Perissinotti, Natasha N Pettit, Zhe Han, Alla Paskovaty, Prasanna P. Narayanan, Christina G. Rivera, Jennifer Delacruz, Meier Hsu, Marisa H. Miceli, Zivile Gedrimaite

Publikováno v: The Journal of antimicrobial chemotherapy. 72(8)

Objectives The association of posaconazole serum concentrations and toxicity is unclear. An assessment of whether levels obtained with the delayed-release tablet (DRT) formulation are correlated with abnormal liver function test (LFT) results and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8567a6ec6dc8b7253f47c2facb4a63ad
https://pubmed.ncbi.nlm.nih.gov/28475803

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Antimicrobial stewardship efforts to manage a pentamidine shortage

Autor: Alla Paskovaty, Melissa Pozotrigo, Priti Patel, Marie Ryan, Charles D. Lucarelli, Jennifer Thackray, Brian Seyboth, Nina Orsini, Susan K. Seo

Publikováno v: American Journal of Health-System Pharmacy. 71:2014-2018

The number of drug shortages quadrupled from 2004, with 58 shortages, to 267 in 2011.[1][1] Eighty percent of the 127 studied shortages in 2010–11 involved sterile injections, and the leading causes for the reported sterile injection shortages incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f776ed7d3efa81034d98bd359d37f608
https://doi.org/10.2146/ajhp130661

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Akademický článek

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Akademický článek

Antimicrobial stewardship efforts to manage a pentamidine shortage.

Autor: Paskovaty, Alla¹ paskovaa@gmail.com, Lucarelli, Charles D.², Patel, Priti³, Ryan, Marie⁴, Seyboth, Brian⁵, Thackray, Jennifer⁵, Pozotrigo, Melissa⁵, Orsini, Nina¹, Seo, Susan K.^6,7

Publikováno v: American Journal of Health-System Pharmacy. 12/1/2014, Vol. 71 Issue 23, p2014-2018. 3p.

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