Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Pasi Koskimies"'
Autor:
Taija Heinosalo, Kalle T. Rytkönen, Niina Saarinen, Päivi Järvensivu, Pauliina Damdimopoulou, Leena Strauss, Satu Orasniemi, Petricia Horshauge, Michael Gabriel, Pasi Koskimies, Claes Ohlsson, Pauliina Kronqvist, Matti Poutanen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4815 (2022)
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice universally ove
Externí odkaz:
https://doaj.org/article/9671d22324714c24bd99a1be883dcd3e
Autor:
Sanna Niinivehmas, Pekka A. Postila, Sanna Rauhamäki, Elangovan Manivannan, Sami Kortet, Mira Ahinko, Pasi Huuskonen, Niina Nyberg, Pasi Koskimies, Sakari Lätti, Elina Multamäki, Risto O. Juvonen, Hannu Raunio, Markku Pasanen, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HS
Externí odkaz:
https://doaj.org/article/ca9ca7ff4f1a4f61961e932f9fb13641
Autor:
Gonda Konings, Linda Brentjens, Bert Delvoux, Tero Linnanen, Karlijn Cornel, Pasi Koskimies, Marlies Bongers, Roy Kruitwagen, Sofia Xanthoulea, Andrea Romano
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Our understanding of the intracrine (or local) regulation of estrogen and other steroid synthesis and degradation expanded in the last decades, also thanks to recent technological advances in chromatography mass-spectrometry. Estrogen responsive tiss
Externí odkaz:
https://doaj.org/article/dc8efb1b42364a999c6db183b7c71965
Autor:
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depress
Externí odkaz:
https://doaj.org/article/7ce7e89c445b4b708ee76689792f6021
Autor:
Gonda FJ Konings, Niina Saarinen, Bert Delvoux, Loes Kooreman, Pasi Koskimies, Camilla Krakstad, Kristine E. Fasmer, Ingfrid S. Haldorsen, Amina Zaffagnini, Merja R. Häkkinen, Seppo Auriola, Ludwig Dubois, Natasja Lieuwes, Frank Verhaegen, Lotte EJR Schyns, Roy FPM Kruitwagen, ENITEC Consortium, Sofia Xanthoulea, Andrea Romano
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2547 (2018)
Endometrial cancer (EC) is the most common gynaecological malignancy in Western society and the majority of cases are estrogen dependent. While endocrine drugs proved to be of insufficient therapeutic value in the past, recent clinical research shows
Externí odkaz:
https://doaj.org/article/b36a8af33c9843f7928573c3e44a0db3
Autor:
Niina Saarinen, Gonda Konings, Roy F.P.M. Kruitwagen, Enitec, Elisabetta d'Avanzo, Loes F. S. Kooreman, Seppo Auriola, Florian Caiment, Frank Verhaegen, Sofia Xanthoulea, Youssef Walid, B. Delvoux, Natasja G. Lieuwes, Pasi Koskimies, Merja R. Häkkinen, Andrea Romano
Publikováno v:
Cancer Letters, 508, 18-29. Elsevier Ireland Ltd
Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC cases are estrogen-dependent. Type 1 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD-1)
Autor:
Poutanen, Taija Heinosalo, Kalle T. Rytkönen, Niina Saarinen, Päivi Järvensivu, Pauliina Damdimopoulou, Leena Strauss, Satu Orasniemi, Petricia Horshauge, Michael Gabriel, Pasi Koskimies, Claes Ohlsson, Pauliina Kronqvist, Matti
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4815
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice universally ove
Autor:
Arjan J. Groot, Karlijn M. C. Cornel, Andrea Romano, Margaretha A. Skowron, Helga B. Salvesen, Camilla Krakstad, Sofia Xanthoulea, Marc Vooijs, Bert Delvoux, Marlies Y. Bongers, Pasi Koskimies, Loes F. S. Kooreman, Roy F.P.M. Kruitwagen, Kim van Kuijk, Gonda Konings, Yannick Schrooders
Publikováno v:
The Journal of Pathology. 244:203-214
The enzyme type 1 17β-hydroxysteroid dehydrogenase (17β-HSD-1), responsible for generating active 17β-estradiol (E2) from low-active estrone (E1), is overexpressed in endometrial cancer (EC), thus implicating an increased intra-tissue generation o
Autor:
Pekka A. Postila, Elina Multamäki, Sanna Niinivehmas, Markku Pasanen, Juhani Huuskonen, Risto O. Juvonen, Pasi Koskimies, Niina Nyberg, Sakari Lätti, Pasi Huuskonen, Hannu Raunio, Sami Kortet, Olli T. Pentikäinen, Mira Ahinko, Elangovan Manivannan, Sanna Rauhamäki
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-b-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced 62% HSD1 i
Autor:
Loes F. S. Kooreman, Niina Saarinen, Bert Delvoux, Florian Caiment, Youssef Walid, Seppo Auriola, Roy F.P.M. Kruitwagen, Natasja G. Lieuwes, Andrea Romano, Sofia Xanthoulea, Gonda Konings, Pasi Koskimies, Merja R. Häkkinen, Frank Verhaegen, Elisabetta d'Avanzo
Publikováno v:
Cancer Research. 81:2931-2931
Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC cases are estrogen-dependent. Type 1 17β-hydroxysteroid dehydrogenase (17β-HSD-1) is the