Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Pasi K. Korhonen"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3081-3089 (2024)
Detailed explorations of the model organisms Caenorhabditis elegans (elegant worm) and Drosophila melanogaster (vinegar fly) have substantially improved our knowledge and understanding of biological processes and pathways in metazoan organisms. Exten
Externí odkaz:
https://doaj.org/article/937c74c759464ab6b630662bd2744f4f
Autor:
Pasi K. Korhonen, Tao Wang, Neil D. Young, Joseph J. Byrne, Tulio L. Campos, Bill C.H. Chang, Aya C. Taki, Robin B. Gasser
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1026-1035 (2024)
Advances in single cell technologies are allowing investigations of a wide range of biological processes and pathways in animals, such as the multicellular model organism Caenorhabditis elegans – a free-living nematode. However, there has been limi
Externí odkaz:
https://doaj.org/article/7ab010327aba4ea691e436fd01e2f0e5
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 24, Iss , Pp 100522- (2024)
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against
Externí odkaz:
https://doaj.org/article/bd1202bcf63a4ff0ade2f378a914072b
Autor:
Pasi K. Korhonen, Liina Kinkar, Neil D. Young, Huimin Cai, Marshall W. Lightowlers, Charles Gauci, Abdul Jabbar, Bill C. H. Chang, Tao Wang, Andreas Hofmann, Anson V. Koehler, Junhua Li, Jiandong Li, Daxi Wang, Jiefang Yin, Huanming Yang, David J. Jenkins, Urmas Saarma, Teivi Laurimäe, Mohammad Rostami-Nejad, Malik Irshadullah, Hossein Mirhendi, Mitra Sharbatkhori, Francisco Ponce-Gordo, Sami Simsek, Adriano Casulli, Houria Zait, Hripsime Atoyan, Mario Luiz de la Rue, Thomas Romig, Marion Wassermann, Sargis A. Aghayan, Hasmik Gevorgyan, Bicheng Yang, Robin B. Gasser
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
A high-quality genome for the parasitic tapeworm, Echinococcus granulosus, provides further insight into the EG95 vaccine target for cystic echinococcosis.
Externí odkaz:
https://doaj.org/article/bb1da2cbaea74461910660645f101d95
Autor:
Neil D. Young, Andreas J. Stroehlein, Tao Wang, Pasi K. Korhonen, Margaret Mentink-Kane, J. Russell Stothard, David Rollinson, Robin B. Gasser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The snail Bulinus truncatus is an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium. Here the authors report the genome of Bu. truncatus, explore protein groups inferred to play a role in its interaction with the schisto
Externí odkaz:
https://doaj.org/article/8cd0b85e29f14f97b9f78b107fb38b5c
Autor:
Tao Wang, Robin B. Gasser, Pasi K. Korhonen, Neil D. Young, Ching-Seng Ang, Nicholas A. Williamson, Guangxu Ma, Gangi R. Samarawickrama, Deepani D. Fernando, Katja Fischer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 12 (2022)
Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a high throughput LC-MS/MS-based approach, we undertook the first comprehensive, large-scale proteomic investigation of egg a
Externí odkaz:
https://doaj.org/article/10758797eeb047378b95bec36e3e9bfd
Autor:
Aya C. Taki, Tao Wang, Nghi N. Nguyen, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Joseph J. Byrne, Neil D. Young, Yuanting Zheng, Guangxu Ma, Pasi K. Korhonen, Anson V. Koehler, Nicholas A. Williamson, Andreas Hofmann, Bill C. H. Chang, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these dru
Externí odkaz:
https://doaj.org/article/9c2e2b7509564909be768e1c02e98074
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1093-1102 (2020)
Defining genes that are essential for life has major implications for understanding critical biological processes and mechanisms. Although essential genes have been identified and characterised experimentally using functional genomic tools, it is cha
Externí odkaz:
https://doaj.org/article/d5003081af5f49338c2dd10ccb300148
Autor:
Gregg W. C. Thomas, Elias Dohmen, Daniel S. T. Hughes, Shwetha C. Murali, Monica Poelchau, Karl Glastad, Clare A. Anstead, Nadia A. Ayoub, Phillip Batterham, Michelle Bellair, Greta J. Binford, Hsu Chao, Yolanda H. Chen, Christopher Childers, Huyen Dinh, Harsha Vardhan Doddapaneni, Jian J. Duan, Shannon Dugan, Lauren A. Esposito, Markus Friedrich, Jessica Garb, Robin B. Gasser, Michael A. D. Goodisman, Dawn E. Gundersen-Rindal, Yi Han, Alfred M. Handler, Masatsugu Hatakeyama, Lars Hering, Wayne B. Hunter, Panagiotis Ioannidis, Joy C. Jayaseelan, Divya Kalra, Abderrahman Khila, Pasi K. Korhonen, Carol Eunmi Lee, Sandra L. Lee, Yiyuan Li, Amelia R. I. Lindsey, Georg Mayer, Alistair P. McGregor, Duane D. McKenna, Bernhard Misof, Mala Munidasa, Monica Munoz-Torres, Donna M. Muzny, Oliver Niehuis, Nkechinyere Osuji-Lacy, Subba R. Palli, Kristen A. Panfilio, Matthias Pechmann, Trent Perry, Ralph S. Peters, Helen C. Poynton, Nikola-Michael Prpic, Jiaxin Qu, Dorith Rotenberg, Coby Schal, Sean D. Schoville, Erin D. Scully, Evette Skinner, Daniel B. Sloan, Richard Stouthamer, Michael R. Strand, Nikolaus U. Szucsich, Asela Wijeratne, Neil D. Young, Eduardo E. Zattara, Joshua B. Benoit, Evgeny M. Zdobnov, Michael E. Pfrender, Kevin J. Hackett, John H. Werren, Kim C. Worley, Richard A. Gibbs, Ariel D. Chipman, Robert M. Waterhouse, Erich Bornberg-Bauer, Matthew W. Hahn, Stephen Richards
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive chang
Externí odkaz:
https://doaj.org/article/e2b9c942e13d4b4295d07ee646e36903
Autor:
Andreas J. Stroehlein, Pasi K. Korhonen, V. Vern Lee, Stuart A. Ralph, Margaret Mentink-Kane, Hong You, Donald P. McManus, Louis-Albert Tchuem Tchuenté, J. Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M. Emery, Bonnie L. Webster, Paul J. Brindley, David Rollinson, Bill C. H. Chang, Robin B. Gasser, Neil D. Young
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2 (2022)
Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenita
Externí odkaz:
https://doaj.org/article/fefe19173810481c8b859d7a47f4f70f