Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pasi Halonen"'
Autor:
Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3946-3959.e6 (2018)
Summary: Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However,
Externí odkaz:
https://doaj.org/article/949872a446914ec6b8703403d441a789
Autor:
Chong Sun, Sebastijan Hobor, Andrea Bertotti, Davide Zecchin, Sidong Huang, Francesco Galimi, Francesca Cottino, Anirudh Prahallad, Wipawadee Grernrum, Anna Tzani, Andreas Schlicker, Lodewyk F.A. Wessels, Egbert F. Smit, Erik Thunnissen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Federica Di Nicolantonio, Alberto Bardelli, Livio Trusolino, Rene Bernards
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 86-93 (2014)
There are no effective therapies for the ∼30% of human malignancies with mutant RAS oncogenes. Using a kinome-centered synthetic lethality screen, we find that suppression of the ERBB3 receptor tyrosine kinase sensitizes KRAS mutant lung and colon
Externí odkaz:
https://doaj.org/article/a91292cb8a2f4412b3021bca6241b5b1
Autor:
Marko J. Kallio, Antti Poso, Lila Kallio, Arne Lindqvist, Pasi Halonen, Elvira Hukasova, Pekka Tiikkainen, Elli Narvi, Jonathan Rehnberg, Leena J. Laine, Jenni H.E. Mäki-Jouppila
Supplemental Movie 1. Cent-1 treated HeLa H2B-GFP mCherry-tubulin cells arrest in mitosis for several hours with misaligned chromosomes, followed by cell death or abnormal exit from M phase. The cell on the left hand side forms a multipolar spindle a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048e2331a542dfa6a6340a8df14f34ef
https://doi.org/10.1158/1535-7163.22500160
https://doi.org/10.1158/1535-7163.22500160
Autor:
Marko J. Kallio, Antti Poso, Lila Kallio, Arne Lindqvist, Pasi Halonen, Elvira Hukasova, Pekka Tiikkainen, Elli Narvi, Jonathan Rehnberg, Leena J. Laine, Jenni H.E. Mäki-Jouppila
Mitosis is an attractive target for the development of new anticancer drugs. In a search for novel mitotic inhibitors, we virtually screened for low molecular weight compounds that would possess similar steric and electrostatic features, but differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e66c27df748880b1259d18eaba3507
https://doi.org/10.1158/1535-7163.c.6536371.v1
https://doi.org/10.1158/1535-7163.c.6536371.v1
Autor:
Olli Kallioniemi, Merja Perälä, Roland C. Grafström, Vidal Fey, Pekka Kohonen, Pasi Halonen, Paula Vainio, Kirsi Ketola, Kristiina Iljin
Supplementary Data from High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3917bf7ae73958f4ba0dd75a40f147
https://doi.org/10.1158/1078-0432.22440433
https://doi.org/10.1158/1078-0432.22440433
Autor:
Olli Kallioniemi, Merja Perälä, Roland C. Grafström, Vidal Fey, Pekka Kohonen, Pasi Halonen, Paula Vainio, Kirsi Ketola, Kristiina Iljin
Purpose: To identify novel therapeutic opportunities for patients with prostate cancer, we applied high-throughput screening to systematically explore most currently marketed drugs and drug-like molecules for their efficacy against a panel of prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bf9c86799cf4642208892147e571e7
https://doi.org/10.1158/1078-0432.c.6517762.v1
https://doi.org/10.1158/1078-0432.c.6517762.v1
Autor:
Federica Di Nicolantonio, Pasi Halonen, Wipawadee Grernrum, Alberto Bardelli, Davide Zecchin, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Livio Trusolino, Anna Tzani, Anirudh Prahallad, Francesca Cottino, Egbert F. Smit, Andreas Schlicker, Chong Sun, Sebastijan Hobor, Francesco Galimi, Andrea Bertotti, Sidong Huang, Erik Thunnissen, René Bernards
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 86-93 (2014)
Cell Reports, 7(1), 86-93. Cell Press
Sun, C, Hobor, S, Bertotti, A, Zecchin, D, Huang, S D, Galimi, F, Cottino, F, Prahallad, A, Grernrum, W, Tzani, A, Schlicker, A, Wessels, L F A, Smit, E F, Thunnissen, E, Halonen, P, Lieftink, C, Beijersbergen, R L, Di Nicolantonio, F, Bardelli, A, Trusolino, L & Bernards, R 2014, ' Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3 ', Cell Reports, vol. 7, no. 1, pp. 86-93 . https://doi.org/10.1016/j.celrep.2014.02.045
Cell Reports, 7(1), 86-93. Cell Press
Sun, C, Hobor, S, Bertotti, A, Zecchin, D, Huang, S D, Galimi, F, Cottino, F, Prahallad, A, Grernrum, W, Tzani, A, Schlicker, A, Wessels, L F A, Smit, E F, Thunnissen, E, Halonen, P, Lieftink, C, Beijersbergen, R L, Di Nicolantonio, F, Bardelli, A, Trusolino, L & Bernards, R 2014, ' Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3 ', Cell Reports, vol. 7, no. 1, pp. 86-93 . https://doi.org/10.1016/j.celrep.2014.02.045
SummaryThere are no effective therapies for the ∼30% of human malignancies with mutant RAS oncogenes. Using a kinome-centered synthetic lethality screen, we find that suppression of the ERBB3 receptor tyrosine kinase sensitizes KRAS mutant lung and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8174e1a0a10a1475124eecd8ad1936c9
http://www.sciencedirect.com/science/article/pii/S2211124714001612
http://www.sciencedirect.com/science/article/pii/S2211124714001612
Autor:
René Bernards, Rodrigo Leite de Oliveira, Cor Lieftink, Roderick L. Beijersbergen, Tonći Šuštić, Pasi Halonen, Michel M. van den Heuvel, Marieke van de Ven, Michiel S. van der Heijden, Liqin Wang
Publikováno v:
European Urology, 71, 6, pp. 858-862
European Urology, 71, 858-862
European Urology, 71, 858-862
Item does not contain fulltext Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary tract. Several fibroblast growth factor receptor (FGFR) inhibitors are currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536320546e1be20617564a45732bf2ef
https://pubmed.ncbi.nlm.nih.gov/28214032
https://pubmed.ncbi.nlm.nih.gov/28214032
Autor:
Sedef Iskit, Daniel S. Peeper, Aida Shahrabi, Pasi Halonen, Patricia A. Possik, Cor Lieftink, Roderick L. Beijersbergen
Publikováno v:
Oncotarget, 7(28), 42859-42872. Impact Journals
Iskit, S, Lieftink, C, Halonen, P, Shahrabi, A, Possik, P A, Beijersbergen, R L & Peeper, D S 2016, ' Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer ', Oncotarget, vol. 7, no. 28, pp. 42859-42872 . https://doi.org/10.18632/oncotarget.10230
Oncotarget
Iskit, S, Lieftink, C, Halonen, P, Shahrabi, A, Possik, P A, Beijersbergen, R L & Peeper, D S 2016, ' Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer ', Oncotarget, vol. 7, no. 28, pp. 42859-42872 . https://doi.org/10.18632/oncotarget.10230
Oncotarget
Breast cancer is the second most common cause of cancer-related deaths worldwide among women. Despite several therapeutic options, 15% of breast cancer patients succumb to the disease owing to tumor relapse and acquired therapy resistance. Particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b2e2a76375475dfd26f61f987f1eb1
https://research.vumc.nl/en/publications/a7697ee0-2515-4fac-a7a9-94858798e39b
https://research.vumc.nl/en/publications/a7697ee0-2515-4fac-a7a9-94858798e39b
Autor:
Jutte van der Werff ten Bosch, Taco W. Kuijpers, Takashi Matozaki, Michel van Houdt, Dieke J van Rees, Paul Kubes, René A. W. van Lier, Catharina W Menke-van der Houven van Oordt, Jeanette H. W. Leusen, Paul Verkuijlen, Katka Franke, Xi Wen Zhao, Liane Babes, Jaap Jan Boelens, Karin Schornagel, Eiji Suzuki, Sergio Rutella, Karl Seeger, Hanke L. Matlung, Hans Janssen, Cor Lieftink, Roderick L. Beijersbergen, Dirk Roos, Louise W. Treffers, Ingrid Kühnle, Timo K. van den Berg, Daria Pagliara, Robin van Bruggen, Pasi Halonen
Publikováno v:
Cell Reports, 23(13), 3946. Cell Press
Cell Reports, Vol 23, Iss 13, Pp 3946-3959.e6 (2018)
Cell reports, 23(13), 3946-3959.e6. Cell Press
Cell Reports, 23(13), 3946-3959.e6. Cell Press
Matlung, H L, Babes, L, Zhao, X W, van Houdt, M, Treffers, L W, van Rees, D J, Franke, K, Schornagel, K, Verkuijlen, P, Janssen, H, Halonen, P, Lieftink, C, Beijersbergen, R L, Leusen, J H W, Boelens, J J, Kuhnle, I, van der Werff Ten Bosch, J, Seeger, K, Rutella, S, Pagliara, D, Matozaki, T, Suzuki, E, Menke-van der Houven van Oordt, C W, van Bruggen, R, Roos, D, van Lier, R A W, Kuijpers, T W, Kubes, P & van den Berg, T K 2018, ' Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis ', Cell Reports, vol. 23, no. 13, pp. 3946-3959.e6 . https://doi.org/10.1016/j.celrep.2018.05.082
Cell Reports, Vol 23, Iss 13, Pp 3946-3959.e6 (2018)
Cell reports, 23(13), 3946-3959.e6. Cell Press
Cell Reports, 23(13), 3946-3959.e6. Cell Press
Matlung, H L, Babes, L, Zhao, X W, van Houdt, M, Treffers, L W, van Rees, D J, Franke, K, Schornagel, K, Verkuijlen, P, Janssen, H, Halonen, P, Lieftink, C, Beijersbergen, R L, Leusen, J H W, Boelens, J J, Kuhnle, I, van der Werff Ten Bosch, J, Seeger, K, Rutella, S, Pagliara, D, Matozaki, T, Suzuki, E, Menke-van der Houven van Oordt, C W, van Bruggen, R, Roos, D, van Lier, R A W, Kuijpers, T W, Kubes, P & van den Berg, T K 2018, ' Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis ', Cell Reports, vol. 23, no. 13, pp. 3946-3959.e6 . https://doi.org/10.1016/j.celrep.2018.05.082
Summary: Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea52655291535ae8ca11d53102ba828
https://doi.org/10.1016/j.celrep.2018.05.082
https://doi.org/10.1016/j.celrep.2018.05.082