Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pasha Apontes"'
Autor:
Maria-Daniela Cirnaru, Sicheng Song, Kizito-Tshitoko Tshilenge, Chuhyon Corwin, Justyna Mleczko, Carlos Galicia Aguirre, Houda Benlhabib, Jaroslav Bendl, Pasha Apontes, John Fullard, Jordi Creus-Muncunill, Azadeh Reyahi, Ali M Nik, Peter Carlsson, Panos Roussos, Sean D Mooney, Lisa M Ellerby, Michelle E Ehrlich
Publikováno v:
eLife, Vol 10 (2021)
Many diseases are linked to dysregulation of the striatum. Striatal function depends on neuronal compartmentation into striosomes and matrix. Striatal projection neurons are GABAergic medium spiny neurons (MSNs), subtyped by selective expression of r
Externí odkaz:
https://doaj.org/article/301679f6c49048c8a4afba920502c74a
Autor:
Jihyeon Lim, Zhongbo Liu, Pasha Apontes, Daorong Feng, Jeffrey E Pessin, Anthony A Sauve, Ruth H Angeletti, Yuling Chi
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90137 (2014)
Chronic over-nutrition is a major contributor to the spread of obesity and its related metabolic disorders. Development of therapeutics has been slow compared to the speedy increase in occurrence of these metabolic disorders. We have identified a nat
Externí odkaz:
https://doaj.org/article/f3e6280e72fa429ca4fd9964e37fd663
Autor:
Jaroslav Bendl, Mads E. Hauberg, Kiran Girdhar, Eunju Im, James M. Vicari, Samir Rahman, Michael B. Fernando, Kayla G. Townsley, Pengfei Dong, Ruth Misir, Steven P. Kleopoulos, Sarah M. Reach, Pasha Apontes, Biao Zeng, Wen Zhang, Georgios Voloudakis, Kristen J. Brennand, Ralph A. Nixon, Vahram Haroutunian, Gabriel E. Hoffman, John F. Fullard, Panos Roussos
Publikováno v:
Bendl, J, Hauberg, M E, Girdhar, K, Im, E, Vicari, J M, Rahman, S, Fernando, M B, Townsley, K G, Dong, P, Misir, R, Kleopoulos, S P, Reach, S M, Apontes, P, Zeng, B, Zhang, W, Voloudakis, G, Brennand, K J, Nixon, R A, Haroutunian, V, Hoffman, G E, Fullard, J F & Roussos, P 2022, ' The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease ', Nature Neuroscience, vol. 25, no. 10, pp. 1366-1378 . https://doi.org/10.1038/s41593-022-01166-7
Nat Neurosci
Nat Neurosci
To characterize the dysregulation of chromatin accessibility in Alzheimer’s disease (AD), we generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the superior temporal gyrus and entorhinal cortex of 153 AD cases and 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ed5dff7de685cf1d386373b8ad4009
https://pure.au.dk/portal/da/publications/the-threedimensional-landscape-of-cortical-chromatin-accessibility-in-alzheimers-disease(6777827c-e6bb-4e67-b387-dec7c9ba155f).html
https://pure.au.dk/portal/da/publications/the-threedimensional-landscape-of-cortical-chromatin-accessibility-in-alzheimers-disease(6777827c-e6bb-4e67-b387-dec7c9ba155f).html
Autor:
John J. Ely, Alexey Kozlenkov, Michael Wegner, Marit W. Vermunt, Ke Hao, Patrick R. Hof, Eugene V. Koonin, Chet C. Sherwood, Jun-Hao Li, Eran A. Mukamel, Stella Dracheva, Pasha Apontes, Menno P. Creyghton
Publikováno v:
Proceedings of the National Academy of Sciences of the U.S.A., 117(45), 28422-28432. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Significance The cerebral cortex of the human brain is a highly complex, heterogeneous tissue that contains many cell types that are exquisitely regulated at the level of gene expression by noncoding regulatory elements, presumably in a cell-type–d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f0d2bcd58643bcd5bb53e232d7598c
https://doi.org/10.1073/pnas.2011884117
https://doi.org/10.1073/pnas.2011884117
Autor:
Pasha Apontes
Publikováno v:
TDP-43 and Neurodegeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99fa104a75ebb907d1ed3b3f3d9a055e
https://doi.org/10.1016/b978-0-12-820066-7.00008-4
https://doi.org/10.1016/b978-0-12-820066-7.00008-4
Autor:
Panos Roussos, Sean D. Mooney, Ali Moussavi Nik, Sicheng Song, Peter Carlsson, John F. Fullard, Jordi Creus-Muncunill, Lisa M. Ellerby, Chuhyon Corwin, Carlos Galicia Aguirre, Michelle E. Ehrlich, Jaroslav Bendl, Justyna Mleczko, Houda Benlhabib, Kizito-Tshitoko Tshilenge, Azadeh Reyahi, Maria-Daniela Cirnaru, Pasha Apontes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ebf2be70f33abbea3aa57c2711dc52
https://doi.org/10.7554/elife.65979.sa2
https://doi.org/10.7554/elife.65979.sa2
Autor:
Kiran Girdhar, Biao Zeng, James M. Vicari, Gabriel E. Hoffman, Samir Rahman, Michael B. Fernando, John F. Fullard, Kristen J. Brennand, Georgios Voloudakis, Pengfei Dong, Jaroslav Bendl, Wen Zhang, Kayla Townsley, Pasha Apontes, Panos Roussos, Vahram Haroutunian, Ruth Misir
Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding the population-level variation of enhancers in the human brain. Besides regulating tissue- and cell-type-specific transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d596e22b6434f2e8d6e6b3026c864036
https://doi.org/10.1101/2021.05.14.443421
https://doi.org/10.1101/2021.05.14.443421
Autor:
Nikita Admane, Md Sheeraz Anwar, Pasha Apontes, Vidhya Bharathi, Oxana V. Galzitskaya, Amandeep Girdhar, Mohd Maksuf Ul Haque, Manoj Kumar Jaiswal, Himanshi Kukrety, Vijay Kumar, Md Zubbair Malik, Basant K. Patel, Samir Rahman, Saurabh Kumar Sharma, R.K. Brojen Singh, Shiv Pratap Singh Yadav, Ankit Srivastava, Anil Kumar Tomar, Nidhi Verma, Savita Yadav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478ec3c44281f490218faf9870da9f3f
https://doi.org/10.1016/b978-0-12-820066-7.01002-x
https://doi.org/10.1016/b978-0-12-820066-7.01002-x
Autor:
Ke Hao, Michael Wegner, Marit W. Vermunt, Stella Dracheva, Patrick R. Hof, Pasha Apontes, Eugene V. Koonin, Menno P. Creyghton, Alexey Kozlenkov, Eran A. Mukamel, John J. Ely, Jun-Hao Li, Chet C. Sherwood
The human cerebral cortex contains many cell types that likely underwent independent functional changes during evolution. However, cell type-specific regulatory landscapes in the cortex remain largely unexplored. Here we report epigenomic and transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46104cb35ba7d22c0a3bffc32ea04113
https://doi.org/10.1101/2020.07.24.219881
https://doi.org/10.1101/2020.07.24.219881
Autor:
Maria-Daniela Cirnaru, Sicheng Song, Kizito-Tshitoko Tshilenge, Chuhyon Corwin, Justyna Mleczko, Carlos Galicia Aguirre, Houda Benlhabib, Jaroslav Bendl, Pasha Apontes, John F. Fullard, Jordi Creus Muncunill, Azadeh Reyah, Ali M. Nik, Peter Carlsson, Panos Roussos, Sean D. Mooney, Lisa M. Ellerby, Michelle E. Ehrlich
The basal ganglia, best known for processing information required for multiple aspects of movement, is also part of a network which regulates reward and cognition. The major output nucleus of the basal ganglia is the striatum, and its functions are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29fd85f1126abd5d16acf51d73f34895
https://doi.org/10.1101/2020.05.19.105171
https://doi.org/10.1101/2020.05.19.105171