The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease

Autor: Jaroslav Bendl, Mads E. Hauberg, Kiran Girdhar, Eunju Im, James M. Vicari, Samir Rahman, Michael B. Fernando, Kayla G. Townsley, Pengfei Dong, Ruth Misir, Steven P. Kleopoulos, Sarah M. Reach, Pasha Apontes, Biao Zeng, Wen Zhang, Georgios Voloudakis, Kristen J. Brennand, Ralph A. Nixon, Vahram Haroutunian, Gabriel E. Hoffman, John F. Fullard, Panos Roussos

Publikováno v: Bendl, J, Hauberg, M E, Girdhar, K, Im, E, Vicari, J M, Rahman, S, Fernando, M B, Townsley, K G, Dong, P, Misir, R, Kleopoulos, S P, Reach, S M, Apontes, P, Zeng, B, Zhang, W, Voloudakis, G, Brennand, K J, Nixon, R A, Haroutunian, V, Hoffman, G E, Fullard, J F & Roussos, P 2022, ' The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease ', Nature Neuroscience, vol. 25, no. 10, pp. 1366-1378 . https://doi.org/10.1038/s41593-022-01166-7
Nat Neurosci

To characterize the dysregulation of chromatin accessibility in Alzheimer’s disease (AD), we generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the superior temporal gyrus and entorhinal cortex of 153 AD cases and 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ed5dff7de685cf1d386373b8ad4009
https://pure.au.dk/portal/da/publications/the-threedimensional-landscape-of-cortical-chromatin-accessibility-in-alzheimers-disease(6777827c-e6bb-4e67-b387-dec7c9ba155f).html

New opportunities for treatment of neurodegenerative disease through the modulation of TDP-43

Autor: Pasha Apontes

Publikováno v: TDP-43 and Neurodegeneration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99fa104a75ebb907d1ed3b3f3d9a055e
https://doi.org/10.1016/b978-0-12-820066-7.00008-4

Dual mode action of mangiferin in mouse liver under high fat diet.

Autor: Jihyeon Lim, Zhongbo Liu, Pasha Apontes, Daorong Feng, Jeffrey E Pessin, Anthony A Sauve, Ruth H Angeletti, Yuling Chi

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90137 (2014)

Chronic over-nutrition is a major contributor to the spread of obesity and its related metabolic disorders. Development of therapeutics has been slow compared to the speedy increase in occurrence of these metabolic disorders. We have identified a nat

Externí odkaz: https://doaj.org/article/f3e6280e72fa429ca4fd9964e37fd663

List of contributors

Autor: Nikita Admane, Md Sheeraz Anwar, Pasha Apontes, Vidhya Bharathi, Oxana V. Galzitskaya, Amandeep Girdhar, Mohd Maksuf Ul Haque, Manoj Kumar Jaiswal, Himanshi Kukrety, Vijay Kumar, Md Zubbair Malik, Basant K. Patel, Samir Rahman, Saurabh Kumar Sharma, R.K. Brojen Singh, Shiv Pratap Singh Yadav, Ankit Srivastava, Anil Kumar Tomar, Nidhi Verma, Savita Yadav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::478ec3c44281f490218faf9870da9f3f
https://doi.org/10.1016/b978-0-12-820066-7.01002-x

Transcriptional and epigenetic characterization of early striosomes identifies Foxf2 and Olig2 as factors required for development of striatal compartmentation and neuronal phenotypic differentiation

Autor: Maria-Daniela Cirnaru, Sicheng Song, Kizito-Tshitoko Tshilenge, Chuhyon Corwin, Justyna Mleczko, Carlos Galicia Aguirre, Houda Benlhabib, Jaroslav Bendl, Pasha Apontes, John F. Fullard, Jordi Creus Muncunill, Azadeh Reyah, Ali M. Nik, Peter Carlsson, Panos Roussos, Sean D. Mooney, Lisa M. Ellerby, Michelle E. Ehrlich

The basal ganglia, best known for processing information required for multiple aspects of movement, is also part of a network which regulates reward and cognition. The major output nucleus of the basal ganglia is the striatum, and its functions are d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29fd85f1126abd5d16acf51d73f34895
https://doi.org/10.1101/2020.05.19.105171