Inhaled corticosteroids reduce senescence in endothelial progenitor cells from COPD patients

Autor: Paschalaki, K, Rossios, C, Pericleous, C, MacLeod, M, Rothery, S, Donaldson, G, Wedzicha, J, Gorgoulis, V, Randi, A, Barnes, P

Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonary disease (COPD) and cardiovascular disease. Using endothelial-colony-forming-cells (ECFC), we have demonstrated accelerated senescence in smokers and COPD patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::71ae361afdb64dfcc7886a43a1ceffad
http://hdl.handle.net/10044/1/93096

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis.

Autor: Evangelou K; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Contributed equally., Veroutis D; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Contributed equally., Paschalaki K; National Heart and Lung Institute, Imperial College London, London, UK.; Contributed equally., Foukas PG; 2nd Dept of Pathology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Lagopati N; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Dimitriou M; 2nd Dept of Pathology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Laboratory of Biology, Dept of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Papaspyropoulos A; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Konda B; Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Hazapis O; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Polyzou A; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Havaki S; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Kotsinas A; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Kittas C; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Tzioufas AG; Dept of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., de Leval L; Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland., Vassilakos D; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Tsiodras S; 4th Dept of Internal Medicine, Attikon University Hospital, University of Athens Medical School, Athens, Greece.; Hellenic Centre for Disease Control and Prevention, Athens, Greece., Stripp BR; Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Papantonis A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.; Center for Molecular Medicine, University of Cologne, Cologne, Germany., Blandino G; Oncogenomic and Epigenetic Unit, IRCCS, Regina Elena National Cancer Institute, Rome, Italy., Karakasiliotis I; Laboratory of Biology, Dept of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Barnes PJ; National Heart and Lung Institute, Imperial College London, London, UK.; P.J. Barnes and V.G. Gorgoulis contributed equally to this article as lead authors and supervised the work., Gorgoulis VG; Molecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece vgorg@med.uoa.gr.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; P.J. Barnes and V.G. Gorgoulis contributed equally to this article as lead authors and supervised the work.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Aug 18; Vol. 60 (2). Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).

Identification of coronavirus particles by electron microscopy: a complementary tool for deciphering COVID-19.

Autor: Havaki S; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Equally contributed., Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Equally contributed., Paschalaki K; National Heart and Lung Institute, Imperial College London, London, UK., Petty R; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Barnes PJ; National Heart and Lung Institute, Imperial College London, London, UK., Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece vgorg@med.uoa.gr.; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Apr 29. Date of Electronic Publication: 2022 Apr 29.

Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes

Autor: Mollet, IG, Patel, D, Govani, FS, Giess, A, Paschalaki, K, Periyasamy, M, Lidington, EC, Mason, JC, Jones, MD, Game, L, Ali, S, Shovlin, CL

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0147990 (2016)

BACKGROUND:Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10μmol/L in the blood stream after iron tablets or infusions, led us to hypothesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b7706d48422a0cbcae684970c2104e7
http://europepmc.org/articles/PMC4750942

Absence of JAK2V617F Mutated Endothelial Colony-Forming Cells in Patients With JAK2V617F Myeloproliferative Neoplasms and Splanchnic Vein Thrombosis.

Autor: Guy A; University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, F-33600 Pessac, France.; CHU de Bordeaux, Laboratoire d'Hématologie, F-33600 Pessac, France., Danaee A; Royal Free London Hospital NHS Trust, University College London Medical School, W12 0NN London, UK., Paschalaki K; National Heart and Lung Institute, Imperial College London, Hammersmith Campus, W12 0NN London, UK., Boureau L; CHU de Bordeaux, Laboratoire d'Hématologie, F-33600 Pessac, France., Rivière E; University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, F-33600 Pessac, France.; CHU de Bordeaux, Service de Médecine Interne, F-33600 Pessac, France., Etienne G; Institut Bergonie, F-33000 Bordeaux, France., Mansier O; University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, F-33600 Pessac, France.; CHU de Bordeaux, Laboratoire d'Hématologie, F-33600 Pessac, France., Laffan M; National Heart and Lung Institute, Imperial College London, Hammersmith Campus, W12 0NN London, UK., Sekhar M; Royal Free London Hospital NHS Trust, University College London Medical School, W12 0NN London, UK., James C; University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, F-33600 Pessac, France.; CHU de Bordeaux, Laboratoire d'Hématologie, F-33600 Pessac, France.

Publikováno v: HemaSphere [Hemasphere] 2020 May 05; Vol. 4 (3), pp. e364. Date of Electronic Publication: 2020 May 05 (Print Publication: 2020).