Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pascale V. Nantermet"'
Autor:
Pascale V. Nantermet, Thomayant Prueksaritanont, William J. Ray, James J. Perkins, Chih-Tai Leu, Fang Chen, Azriel Schmidt, Mark E. Duggan, Viera Kasparcova, Sharon Adamski, Donald B. Kimmel, Leonard P. Freedman, SuJane Rutledge, T. Cusick, Brenda L Pennypacker, George D. Hartman, Jiabing Wang, P. Masarachia, Meissner Robert S, Shun-ichi Harada, Paul Hodor, Robert L. Vogel, Chang Bai, Hai-Zhuan Zhang, Sheila McElwee-Witmer, Helen J. Mitchell, Michael A. Gentile, Evan E. Opas, Angela Scafonas, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 285:17054-17064
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or even antagoniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c9fd8a36b1708c44fd44519c66c7a
https://doi.org/10.1074/jbc.m109.099002
https://doi.org/10.1074/jbc.m109.099002
Autor:
Soumya P. Sahoo, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Meissner Robert S, Fang Chen, William J. Ray, Dwight A. Towler, Shun Ichi Harada, Chang Bai, Angela Scafonas, Mark E. Duggan, Brenda L Pennypacker, Su Jane Rutledge, Azriel Schmidt, Gideon A. Rodan, Sheila McElwee-Witmer, Robert L. Vogel, Michael A. Gentile, George D. Hartman, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 284:36367-36376
Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks for unwanted effects including virilization and hypertrophy of reproductive organs. Selective Androgen Receptor Modulators (SARMs) retain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3561e1ddd1ac61e3162e944e8e5b8d4e
https://doi.org/10.1074/jbc.m109.049734
https://doi.org/10.1074/jbc.m109.049734
Autor:
Gideon A. Rodan, Dwight A. Towler, Azriel Schmidt, Elizabeth T. Birzin, Pascale V. Nantermet, Evan E. Opas, James M. Schaeffer, Hilary A. Wilkinson, Lawrence F. Colwell, Robert R. Wilkening, Angela Scafonas
Publikováno v:
Maturitas. 64:46-51
Objective To test the role of ERβ in the control of estrogen-dependent thermoregulation in rats. Methods Test the ability of an ERβ-selective ligand to suppress the elevation in basal rat tail skin temperature (TST) caused by ovariectomy (OVX). Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2c4de00809dc2c84d456e7b8a35b59
https://doi.org/10.1016/j.maturitas.2009.07.007
https://doi.org/10.1016/j.maturitas.2009.07.007
Autor:
Pascale V. Nantermet, Chun Cheng, Robert L. Vogel, William J. Ray, Hongyue Dai, Paul Hodor, Michael A. Gentile, Robert A. Phillips, Leonard P. Freedman, Daniel J. Holder
Publikováno v:
Journal of Molecular Endocrinology. 44:55-73
Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b7ee6e6bcfd1daf46a363cc221176b
https://doi.org/10.1677/jme-09-0048
https://doi.org/10.1677/jme-09-0048
Autor:
Hai Z. Zhang, Sheila McElwee-Witmer, Azriel Schmidt, Mark E. Duggan, William J. Ray, Chih-Tai Leu, Chang Bai, Pascale V. Nantermet, Donald B. Kimmel, William P. Dankulich, Thomayant Prueksaritanont, Fang Chen, Robert L. Vogel, Michael A. Gentile, Meissner Robert S, George D. Hartman, Helen J. Mitchell
Publikováno v:
Journal of Medicinal Chemistry. 52:4578-4581
A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c999347b3114925de3ef07c508765a6
https://doi.org/10.1021/jm900880r
https://doi.org/10.1021/jm900880r
Autor:
Daniel J. Holder, Donald Kimme, William J. Ray, Yuanjiang Yu, Shun-ichi Harada, Pascale V. Nantermet, Yuan Liu, Spring Cheng, Colena Johnson, Paul Hodor, Robert A. Phillips
Publikováno v:
Endocrinology. 149:1551-1561
Androgens increase muscle mass, decrease fat mass, and reduce high-density lipoprotein cholesterol (HDL), but the relationship between body composition, lipoprotein metabolism, and androgens has not been explained. Here we treated ovariectomized cyno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569c44c5c466e6a84078411aaa0e5ce4
https://doi.org/10.1210/en.2007-1151
https://doi.org/10.1210/en.2007-1151
Autor:
Azriel Schmidt, Shun Ichi Harada, William J. Ray, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Leonard P. Freedman, Daniel J. Holder, Michael A. Gentile, Dwight A. Towler, Brenda L Pennypacker, Jian Xu, David Gerhold
Publikováno v:
Endocrinology. 146:564-578
The androgen receptor (AR) is expressed in the uterus; however, the role of AR in female reproductive physiology is poorly understood. Here we examined the effects of androgens on uterine growth and gene expression in adult ovariectomized rats. Nonar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277aad9faf950575fc55d89351b722ce
https://doi.org/10.1210/en.2004-1132
https://doi.org/10.1210/en.2004-1132
Autor:
Donald B. Kimmel, Pascale V. Nantermet, Fubao Wang, Peter Haytko, Donald E. Williams, Ping Lu, Zhiqiang An, Richard Hampton, Lingyi Huang, John E. Fisher, William R. Strohl, Osvaldo A. Flores, Jing Z. Zhao, Helmut Glantschnig, Salvatore Vitelli, Paul J. McCracken, Nan Wei, K. R. Scott, Jacquelynn J. Cook, Punam Sandhu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 338(2)
Genetic studies have linked both osteoporotic and high bone mass phenotypes to low-density lipoprotein receptor-related proteins (LRP4, LRP5, and LRP6). LRPs are receptors for inhibitory Dickkopf-1 (DKK1) protein, and treatment modalities that modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa19c1c9cebe6b6ebcdfac2597f427b
https://pubmed.ncbi.nlm.nih.gov/21531794
https://pubmed.ncbi.nlm.nih.gov/21531794
Publikováno v:
Molecular and Cellular Biology. 13:3301-3310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a878f62ff09401151f4c5d159675e41
https://doi.org/10.1128/mcb.13.6.3301-3310.1993
https://doi.org/10.1128/mcb.13.6.3301-3310.1993
Autor:
Donald B. Kimmel, Alfred A. Reszka, Fubao Wang, Zhiqiang An, Pascale V. Nantermet, Osvaldo A. Flores, Jing Zhang Zhao, Cheryl Ireland, John E. Fisher, Peter Haytko, Punam Sandhu, Laura Orsatti, T. Cusick, Nan Wei, K. R. Scott, Ping Lu, Richard Hampton, Helmut Glantschnig, Stephen Jarantow, Lingyi Huang, Salvatore Vitelli, Fabio Talamo, William R. Strohl, Robin Ernst
Publikováno v:
The Journal of biological chemistry. 285(51)
Wnt/LRP5 signaling is a central regulatory component of bone formative and resorptive activities, and the pathway inhibitor DKK1 is a suppressor of bone formation and bone mass accrual in mice. In addition, augmented DKK1 levels are associated with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ce9e1217ec90e8ffb0f79a97517a43
https://pubmed.ncbi.nlm.nih.gov/20929859
https://pubmed.ncbi.nlm.nih.gov/20929859